Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Decellularized fish swim bladder patch loaded with mesenchymal stem cells inhibits neointimal hyperplasia
AbstractWe previously showed decellularized fish swim bladder can be used as vascular patch and tube graft in rats, mesenchymal stem cells (MSCs) have showed the capability to inhibit neointimal hyperplasia in different animal models. We hypothesized that decellularized fish swim bladder patch loaded with MSCs (bioinspired patch) can inhibit neointimal hyperplasia in a rat aortic patch angioplasty model. Rat MSCs were grown in vitro and flow cytometry was used to confirm their quality. 3.6  × 105 MSCs were mixed into 100  μl of sodium alginate (SA)/hyaluronic acid (HA) hydrogel, two layers of fish swim bladders (5�...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 6, 2022 Category: Materials Science Authors: Peng Sun, Haoliang Wu, Xiche Bai, Liwei Zhang, Cong Zhang, Xueyun Wang, Chunyang Lou, Bo Li, Zhuo Li, Hualong Bai Tags: RESEARCH ARTICLE Source Type: research

Comprehensive reparative effects of bacteriostatic poly(L ‐lactide‐co‐glycolide)/poly(L‐lactide‐co‐ε‐caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis
In this study a serial clinically applied antibiotics loaded poly(L-lactide-co-glycolide)/poly(L-lactide-co- ε-caprolactone) (PLGA/PLCA) fibrous mesh to prevent and reconstruct defective bone in periodontitis were prepared by electrospinning. Incorporation of antibiotics promoted the hydrophilicity but decreased the crystallinity of PLGA/PLCA membranes. Antibiotics could be sustained released from membran es. Metronidazole, minocycline, and doxycycline incorporated membranes could suppressPorphyromonas gingivalis (P. gingivalis) within 21  days in vitro. Metronidazole and minocycline incorporated membranes decreased 41%...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 5, 2022 Category: Materials Science Authors: Yiming Liu, Yun Zhao, Wanchun Zhu, Mei Han, Fanglin Mi, Bing Wang Tags: RESEARCH ARTICLE Source Type: research

Osseointegration behavior of carbon fiber reinforced polyetheretherketone composites modified with amino groups: An in vivo study
This study aims to evaluate the effect of amino groups modification on the osseointegration behavior of carbon fiber reinforced PEEK (30%-CPEEK) in rabbits. Herein, 30%-CPEEK and A-30%-CPEEK implant discs were implanted in rabbit skulls for 5  weeks, with pure titanium implants serving as a control. The bone-forming ability and osseointegration in vivo were systematically investigated by micro-computed tomography analysis, scanning electron microscope observation, and histological evaluation. Our results showed that all detection param eters were significantly different between the A-30%-CPEEK and 30%-CPEEK groups, favor...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 3, 2022 Category: Materials Science Authors: Junyan Wang, Wanqi Yu, Ruining Shi, Shihui Yang, Jingjie Zhang, Xiao Han, Zhe Zhou, Weijia Gao, Yongli Li, Jinghui Zhao Tags: RESEARCH ARTICLE Source Type: research

Novel nano ‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
This study aimed to investigate the effect of a novel nHA coating on the biological performance of EBMed 3D porous implants in a beagle transcortical model. Low-porosity (control) and high-porosity 3D porous Ti-6Al-4V implants were manufactured using EBM. Half of the high-porosity implants were coated with nHA without clogging the 3D pores. Implants were inserted into the femoral diaphysis of the beagles. The beagles were euthanized at 4, 8, and 12  weeks postoperatively, and push-out testing was performed. Bone ingrowth was evaluated by histological analysis. Although the increase in porosity alone had no effect on biol...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 29, 2022 Category: Materials Science Authors: Ryota Watanabe, Hiroyuki Takahashi, Aira Matsugaki, Toru Uemukai, Yasumichi Kogai, Takashi Imagama, Kiminori Yukata, Takayoshi Nakano, Takashi Sakai Tags: RESEARCH ARTICLE Source Type: research

Sensors ‐based monitoring and treatment approaches for in‐stent restenosis
AbstractCardiovascular disease (CVD) can progressively narrow arteries due to plaque accumulation on the inner walls of the blood vessels, which results in an obstructed blood flow, leading to heart attack, stroke, and even death if the obstruction is severe. A popular treatment for the disease is to use an intravascular mechanical device called the stent to achieve an immediate restoration of blood flow. However, the physical stimulation induced by the stent expansion can cause inflammation of the vessel tissue. As one of the most common post-stenting complications, re-narrowing of the vessel is the main pathology that le...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2022 Category: Materials Science Authors: Ying Yi, Bo Wang, Changping Li Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 16, 2022 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Surface modifications to promote the osteoconductivity of ultra ‐high‐molecular‐weight‐polyethylene fabrics for a novel biomimetic artificial disc prosthesis: An in vitro study
AbstractA novel biomimetic artificial intervertebral disc (bioAID) for the cervical spine was developed, containing a hydrogel core representing the nucleus pulposus, an UHMWPE fiber jacket as annulus fibrosis, and titanium endplates with pins for mechanical fixation. Osseointegration of the UHMWPE fibers to adjacent bone structures is required to achieve proper biomimetic behavior and to provide long-term stability. Therefore, the aim of this study was to assess the osteoconductivity of several surface modifications of UHMWPE fabrics, 2D weft-knitted, using non-treated UHMWPE fibers (N), plasma treated UHMWPE fibers (PT),...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 16, 2022 Category: Materials Science Authors: Celien A. M. Jacobs, Esther E. A. Cramer, Aylvin A. Dias, Harold Smelt, Sandra Hofmann, Keita Ito Tags: RESEARCH ARTICLE Source Type: research

Fabrication of macroporous apatite bone cements for non ‐load bearing orthopedic applications
AbstractCalcium deficient hydroxyapatite (CDHA)-based apatite forming bone cements are well known for their bioactivity and bioresorbability. The formulation of CDHA-based cements with improved macroporosity, injectability, and resorbability has been investigated. The solid phase consists of nanocrystalline hydroxyapatite (HA) and tricalcium phosphate ( β-TCP). The liquid phase is diluted acetic acid with disodium hydrogen phosphate as binding accelerator along with gelatin and chitosan to improve the injectability. A porogen agent either mannitol (as solid porogen) or polysorbate (as liquid porogen) is also used to impro...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 15, 2022 Category: Materials Science Authors: Vimal Kumar Dewangan, Trichirapalli Subramaniam Sampath Kumar, Mukesh Doble, Viju Daniel Varghese Tags: RESEARCH ARTICLE Source Type: research

Impact of surface roughness and bulk porosity on spinal interbody implants
AbstractSpinal fusion surgeries are performed to treat a multitude of cervical and lumbar diseases that lead to pain and disability. Spinal interbody fusion involves inserting a cage between the spinal vertebrae, and is often utilized for indirect neurologic decompression, correction of spinal alignment, anterior column stability, and increased fusion rate. The long-term success of interbody fusion relies on complete osseointegration between the implant surface and vertebral end plates. Titanium (Ti)-based alloys and polyetheretherketone (PEEK) interbody cages represent the most commonly utilized materials and provide suff...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 8, 2022 Category: Materials Science Authors: Hannah A. Levy, Brian A. Karamian, Goutham R. Yalla, Jose A. Canseco, Alexander R. Vaccaro, Christopher K. Kepler Tags: REVIEW ARTICLE Source Type: research

Electrospun nanofiber mesh with connective tissue growth factor and mesenchymal stem cells for pelvic floor repair: Long ‐term study
This study provides new insights into future POP repair in postmenopausal women by showing how CTGF/PF-coated electrospun PCL meshes with stem cells exhibit sufficient support, biocompatibility, and no mesh-related complication s long term in an abdominal repair model in elderly rats. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 8, 2022 Category: Materials Science Authors: Sofie Husted Laursen, Signe Gellert Hansen, Mehmet Berat Taskin, Menglin Chen, Lise Wogensen, Jens Vinge Nygaard, Susanne Maigaard Axelsen Tags: RESEARCH ARTICLE Source Type: research

Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid ‐based bone scaffolds under hydrolytic conditions
AbstractPolylactic acid (PLA) has been extensively used for the manufacturing of scaffolds in bone tissue engineering applications. Due to the low hydrophilicity and the acidic degradation process of this biomaterial, different strategies have been proposed to increase the biofunctionality of the support structure. The use of ceramic particles is a generally preferred option to increase the osteoconductivity of the base material, while acting as buffers to maintain the pH level of the surroundings tissues. Surface modification is another approach to overcome the limitations of PLA for tissue engineering applications. In th...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 7, 2022 Category: Materials Science Authors: Ricardo Donate, Mario Monz ón, María Elena Alemán‐Domínguez, Francisco Rodríguez‐Esparragón Tags: RESEARCH ARTICLE Source Type: research

Novel polycaprolactone (PCL) ‐type I collagen core‐shell electrospun nanofibers for wound healing applications
AbstractType I collagen (Col_1) is one of the main proteins present in the skin extracellular matrix, serving as support for skin regeneration and maturation in its granulation stage. Electrospun materials have been intensively studied as the next generation of skin wound dressing mainly due to their high surface area and fibrous porosity. However, the electrospinning of collagen-based solutions causes degradation of its structure. In this work, a coaxial electrospinning process was proposed to overcome this limitation. The production of mats of polycaprolactone (PCL) –Col_1/PVA (collagen/poly(vinyl alcohol)) composed of...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 7, 2022 Category: Materials Science Authors: Javier Mauricio Anaya Mancipe, Leonardo Cunha Boldrini Pereira, Priscila Grion Miranda Borchio, Marcos Lopes Dias, Rossana Mara Silva Moreira Thir é Tags: RESEARCH ARTICLE Source Type: research

Material properties of degradable alloy Fe –30Mn–0.6N and its effect on ferroptosis in synoviocytes
This study aimed to examine the mechanical properties, degradability and biocompatibility of Fe–30Mn–0.6N alloy and effects of it on synovial tissue ferroptosis. Tensile testing showed that Fe –30Mn–0.6N alloys exhibited tensile strength of 487  ± 18 MPa, yield strength of 221 ± 10 MPa, elongation of 16.9 ± 0.3% and Young's modulus of 37.7 ± 1.3 GPa. In vivo experiments, the cross-sectional area of the Fe–30Mn–0.6N alloys decreased by 73.32  ± 12.73% after 8 weeks of implantation. The results of scanning electron microscopy (SEM) and surface elemental analysis (EDS) showed that ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 6, 2022 Category: Materials Science Authors: Tianyu Yang, Shimin Hao, Penghao Wang, Yu Qin, Guanchao You, Yunyi Shi, Boning Yang, Ao Zhang, Lei Guo, Tianlong Jiang Tags: RESEARCH ARTICLE Source Type: research

Influence of varying thermal treatment on bioactive material with equal Ca/P ratio: A local drug delivery system for bone regeneration
AbstractDesigning a biomaterial with excellent bioactivity, biocompatibility, mechanical strength, porosity, and osteogenic properties is essential to incorporate therapeutic agents in order to promote efficient bone regeneration. The work intended to prepare bioactive glass with tailor-made equal Ca/P (CP) ratio to obtain clinophosinaite (Cpt) as dominant phase. Clinophosinaite (Na3CaPSiO7) is one of the rarest phases of bioactive glass (BG), which is supposed to play key role in bioactivity. The novelty of this work is to track the required sintering temperature to attain equimolar calcium phosphate-containing clinophosi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 5, 2022 Category: Materials Science Authors: Elakkiya Krishnamoorthy, Vijayakumari Sugumaran, Radha Gosala, Bargavi Purushothaman, Balakumar Subramanian Tags: RESEARCH ARTICLE Source Type: research

Design of new hydrolyzed collagen ‐modified magnetic nanoparticles to capture pathogens
In this study, a novel approach was described that enables selective capture of bacteria expressing hydrolyzed collagen-binding adhesins with hydrolyzed collagen-coated magnetic nanoparticles (MNPs). This platform could be useful to shorten the time needed to confirm the presence of a bacterial infection. MNPs were synthesized by a simple two-step approach through a green co-precipitation method using water as solvent. These MNPs were specifically designed to interact with pathogenic bacteria by establishing a hydrolyzed collagen-adhesin linker. The bacterial capture efficacy of hydrolyzed collagen MNPs (H-Coll@MNPs) for b...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 5, 2022 Category: Materials Science Authors: Maria G. Sande, L úcia Roque, Adelaide Braga, Márcia Marques, Débora Ferreira, Athanasios Saragliadis, Joana L. Rodrigues, Dirk Linke, David Ramada, Carla Silva, Lígia R. Rodrigues Tags: RESEARCH ARTICLE Source Type: research