Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Finite element analysis of vertebroplasty in the osteoporotic T11 ‐L1 vertebral body: Effects of bone cement formulation
AbstractVertebral compression fractures are one of the most severe clinical consequences of osteoporosis and the most common fragility fracture afflicting 570 and 1070 out of 100,000 men and women worldwide, respectively. Vertebroplasty (VP), a minimally invasive surgical procedure that involves the percutaneous injection of bone cement, is one of the most efficacious methods to stabilise osteoporotic vertebral compression fractures. However, postoperative fracture has been observed in up to 30% of patients following VP. Therefore, this study aims to investigate the effect of different injectable bone cement formulations o...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - January 5, 2024 Category: Materials Science Authors: Subrata Mondal, David B. MacManus, Federica Banche ‐Niclot, Chiara Vitale‐Brovarone, Sonia Fiorilli, Helen O. McCarthy, Nicholas Dunne Tags: RESEARCH ARTICLE Source Type: research

Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells
This study demonst rated that Sr and ordered structure in a-PLGA/SrCSH fibrous scaffolds could synergistically enhance the osteogenic differentiation of umbilical cord mesenchymal stem cells (UCMSCs) by regulating cell arrangement and expressions of osteogenic genes. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - January 5, 2024 Category: Materials Science Authors: Lichu Liu, Pin Luo, Honghong Liao, Kuangyang Yang, Shenyu Yang, Mei Tu Tags: RESEARCH ARTICLE Source Type: research

Direct inkjet writing type 1 bovine collagen/ β‐tricalcium phosphate scaffolds for bone regeneration
This study aimed to develop and characterize 3D printed scaffolds composed of type I collagen augmented with β-tricalcium phosphate (COL/β-TCP). A custom-built direct inkjet write (DIW) printer was used to fabricate β-TCP, COL, and COL/β-TCP scaffolds using synthesized colloidal gels. After chemical crosslinking, the scaffolds were lyophilized and subjected to several characterization techniques, inclu ding light microscopy, scanning electron microscopy, and x-ray diffraction to evaluate morphological and chemical properties. In vitro evaluation was performed using human osteoprogenitor cells to assess cytotoxicity and...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 30, 2023 Category: Materials Science Authors: Angel Cabrera Pereira, Nick Tovar, Vasudev Vivekanand Nayak, Dindo Q. Mijares, James E. Smay, Andrea Torroni, Roberto L. Flores, Lukasz Witek Tags: RESEARCH ARTICLE Source Type: research

Bifunctional tissue ‐engineered composite construct for bone regeneration: The role of copper and fibrin
AbstractBifunctional tissue engineering constructs promoting osteogenesis and angiogenesis are essential for bone regeneration. Metal ion-incorporated scaffolds and fibrin encapsulation attract much attention due to low cost, nontoxicity, and tunable control over ion and growth factor release. Herein, we investigated the effect of Cu.nHA/Cs/Gel scaffold and fibrin encapsulation on osteogenic and angiogenic differentiation of Wharton's jelly mesenchymal stem cells (WJMSCs) in vitro and in vivo. Cu-laden scaffolds were synthesized using salt leaching/freeze drying and were characterized using standard techniques. WJMSCs were...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 21, 2023 Category: Materials Science Authors: Azam Bozorgi, Mozafar Khazaei, Maryam Bozorgi, Leila Sabouri, Mansooreh Soleimani, Zahra Jamalpoor Tags: RESEARCH ARTICLE Source Type: research

Effect of gamma irradiation and supercritical carbon dioxide sterilization with Novakill ™ or ethanol on the fracture toughness of cortical bone
AbstractSterilization of structural bone allografts is a critical process prior to their clinical use in large cortical bone defects. Gamma irradiation protocols are known to affect tissue integrity in a dose dependent manner. Alternative sterilization treatments, such as supercritical carbon dioxide (SCCO2), are gaining popularity due to advantages such as minimal exposure to denaturants, the lack of toxic residues, superior tissue penetration, and minor impacts on mechanical properties including strength and stiffness. The impact of SCCO2 on the fracture toughness of bone tissue, however, remains unknown. Here, we evalua...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 21, 2023 Category: Materials Science Authors: Mihee Shin, Matthew H. Pelletier, Vedran Lovric, William R. Walsh, Penny J. Martens, Jamie J. Kruzic, Bernd Gludovatz Tags: RESEARCH ARTICLE Source Type: research

Pit initiation on biomedical alloys —A review
AbstractBiomedical alloys, like many engineering alloys, have chemical or physical heterogeneities at the surface, and such heterogeneities can potentially act as sites for pit initiation. Alloys of particular interest are 316/316L (and 316LVM) stainless steel, nitinol, and CoCr alloys. This review focuses on the sites —generally inclusions—that have been associated with pitting in various studies of biomedical alloys in simulated physiological solutions. The effect of these sites is discussed in relation to factors such as type and size. For both 316/316L stainless steel and nitinol, pitting has been found to initiate...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 19, 2023 Category: Materials Science Authors: Bruce G. Pound Tags: REVIEW ARTICLE Source Type: research

Preclinical models for studying corticosteroid ‐induced osteonecrosis of the femoral head
AbstractNontraumatic osteonecrosis of the femoral head (ONFH) is a refractory condition that commonly results in femoral head collapse and degenerative arthritis of the hip. In the early stages, surgical procedures for hip preservation, including core decompression (CD), have been developed to prevent progressive collapse of the femoral head. Optimization of bone regeneration and biological augmentation may further enhance the therapeutic efficacy of CD for ONFH. Thus, combining CD with cell-based therapy has recently been proposed. In fact, patients treated with cell-based therapy using autologous bone marrow concentrate ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 18, 2023 Category: Materials Science Authors: Masanori Tsubosaka, Masahiro Maruyama, Elaine Lui, Junichi Kushioka, Masakazu Toya, Qi Gao, Huaishuang Shen, Xueping Li, Simon Kwoon ‐Ho Chow, Ning Zhang, Yunzhi Peter Yang, Stuart B. Goodman Tags: REVIEW ARTICLE Source Type: research

Characterization and in ‐vitro assessment of silicon‐based apatite microspheres for bone tissue engineering applications
AbstractIn the field of bone tissue engineering, silicon (Si) has been found as an essential element for bone growth. However, the use of silicon in bioceramics microspheres remains limited. In this work, different weight percentages (0.8, 1.6, and 2.4  wt %) of silicon was incorporated into hydroxyapatite and fabricated into microspheres. 2.4 wt % of Si incorporated into HAp microspheres (2.4 SiHAp) were found to enhance functional properties of the microspheres which resulted in improved cell viability of human mesenchymal stem cells (hMSCs) , demonstrating rapid cell proliferation rates resulting in high cell densit...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 18, 2023 Category: Materials Science Authors: Chien Yi Wee, Quentin Ray Tjieh Lim, Xin Xu, Zhijie Yang, Dong Wang, Eng San Thian Tags: RESEARCH ARTICLE Source Type: research

Review of electrospun microtube array membrane (MTAM) ‐a novel new class of hollow fiber for encapsulated cell therapy (ECT) in clinical applications
AbstractEncapsulated cell therapy (ECT) shows significant potential for treating neurodegenerative disorders including Alzheimer's and Parkinson's, which currently lack curative medicines and must be managed symptomatically. This novel technique encapsulates functional cells with a semi-permeable membrane, providing protection while enabling critical nutrients and therapeutic substances to pass through. Traditional ECT procedures, on the other hand, pose difficulties in terms of cell survival and retrieval. We introduce the Microtube Array Membrane (MTAM), a revolutionary technology that solves these constraints, in this c...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 18, 2023 Category: Materials Science Authors: Chee Ho Chew, Hsin ‐Lun Lee, Amanda Lin Chen, Wan‐Ting Huang, Shu‐Mei Chen, Yen‐Lin Liu, Chien‐Chung Chen Tags: REVIEW ARTICLE Source Type: research

Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function
In conclusion, the PLCL bilayer membrane is a promising biomaterial for use in GBR given its slow degradation and prolonged barrier function. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 13, 2023 Category: Materials Science Authors: Gabriela L. Abe, Jun ‐Ichi Sasaki, Ririko Tsuboi, Tomoki Kohno, Haruaki Kitagawa, Satoshi Imazato Tags: RESEARCH ARTICLE Source Type: research

Isolation of TiNbN wear particles from a coated metal ‐on‐metal bearing: Morphological characterization and in vitro evaluation of cytotoxicity in human osteoblasts
This study investigated the biological response of human osteoblasts to wear particles generated from TiNbN-coated hip implants. Abrasive particles were generated in a hip simulator according to ISO 14242-1/ −2 and extracted with Proteinase K. Particle characteristics were evaluated by electron microscopy and energy dispersive x-ray spectroscopy (EDS), inductively coupled plasma mass spectrometry (ICP-MS) and dynamic light scattering (DLS) measurements. Human osteoblasts were exposed to different part icle dilutions (1:20, 1:50, and 1:100), and cell viability and gene expression levels of osteogenic markers and inflammat...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 12, 2023 Category: Materials Science Authors: Marie ‐Luise Sellin, Anika Seyfarth‐Sehlke, Mahammad Aziz, Christian Fabry, Katrin Wenke, Paul Johan Høl, Ivan Rios‐Mondragon, Mihaela Roxana Cimpan, Marcus Frank, Rainer Bader, Anika Jonitz‐Heincke Tags: RESEARCH ARTICLE Source Type: research

Enhanced osteogenicity of the demineralized bone ‐dermal matrix composite by the optimal partial demineralization for sustained release of bioactive molecules
Fabrication process and testing of DBM/ADM composites. AbstractAllogenic demineralized bone matrix (DBM), processed to expose bioactive proteins imbedded by calcium salts, is widely used for bone repair and regeneration as an alternative to the autologous bone graft. However, demineralized bone matrices from tissue banks vary significantly in residual calcium content and osteogenicity for clinical bone regeneration. The present study produced DBM with various residual calcium contents by partial demineralization using ethylenediaminetetraacetic acid disodium (EDTA) and hydrochloric acid. Compositional analysis reveals that...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 12, 2023 Category: Materials Science Authors: Tong Ma, Dangli Ren, Jingjing Wang, Feng Fu, Wendell Q. Sun, Hongtao Sun Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 6, 2023 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Epidermis of Cereus hildmannianus as a biomimetic scaffold for tissue engineering
AbstractA thin plastic-like film separated from the epidermis ofCereus hildmannianus has excellent tensile strength, resistance to water and high antimicrobial activity and supports the growth of mouse fibroblast cells. Cactuses are one of the most under explored plant species with high potential for food, materials, pharmaceutical and other applications. Although studies have shown the ability of cactuses to be used for food, as a source for fibers, as reinforcement for composites and other applications, the role of individual layers and their properties has been studied to a limited extent. In this paper, a thin transluc...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 26, 2023 Category: Materials Science Authors: Narendra Reddy, Roopa Reddy, Vijaykumar Guna, G. S. Nagananda, Pornanong Aramwit Tags: RESEARCH ARTICLE Source Type: research

Interpenetrating alginate network as drug delivery matrix: Effects on protein stability and release
AbstractThe study investigates the rheological properties and protein release capacity of a uniform hydrogel composed of sodium alginate (SA) and poloxamer (P407). The hydrogel is prepared through the sustained release of calcium ions, resulting in a reinforced and homogeneous interpenetrating networks (IPNs) of SA and P407 polymeric chains. By adjusting the amount of crosslink agent, the hydrogel exhibites an adjustable dissolution ratio and adaptable gelling time. Moreover, the composite showed a well-structured network and superior mechanical strength, enabling the sustained release of both calcium ions and Soybean Tryp...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 21, 2023 Category: Materials Science Authors: Ana P. F. Monteiro, Aurora P érez‐Jiménez, Claire Spitzlei, Joachim Caucheteux, Vitor Delgado Alves, Stéphanie Lambert, Christian Grandfils Tags: RESEARCH ARTICLE Source Type: research