Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A dual ‐action nitric oxide‐releasing slippery surface for extracorporeal organ support: Dynamic in vitro hemocompatibility evaluation
AbstractNumerous biomaterials have been developed for application in blood-contacting medical devices to prevent thrombosis; however, few materials have been applied to full-scale devices and evaluated for hemocompatibility under clinical blood flow conditions. We applied a dual-action slippery liquid-infused (LI) nitric oxide (NO)-releasing material modification (LINO) to full-scale blood circulation tubing for extracorporeal lung support and evaluated the tubing ex vivo using swine whole blood circulated for 6  h at a clinically relevant flow. LINO tubing was compared to unmodified tubing (CTRL) and isolated LI and NO-r...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 21, 2022 Category: Materials Science Authors: Teryn R. Roberts, George T. Harea, Yanyi Zang, Ryan P. Devine, Patrick Maffe, Hitesh Handa, Andriy I. Batchinsky Tags: RESEARCH ARTICLE Source Type: research

A dynamic pedicle screw system using polyethylene insert for the lumbar spine
AbstractRigid spinal fusion with instrumentation has been widely applied in treating degenerative spinal disorders and has shown excellent and stable surgical results. However, adjacent segment pathology or implants' loosening could be problematic due to the spine's segmental fusion. Therefore, this study verified a novel concept for posterior stabilization with polyethylene inserts inside a pedicle screw assembly using bone models. We observed that although the gripping capacity of the dynamic pedicle screw system using a tensile and compression tester was less than half that of the rigid pedicle screw system, the flexion...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 19, 2022 Category: Materials Science Authors: Yasushi Oshima, So Kato, Toru Doi, Yuki Taniguchi, Yoshitaka Matsubayashi, Nozomu Ohtomo, Kenichi Watanabe, Masayuki Kyomoto, Sakae Tanaka, Toru Moro Tags: RESEARCH ARTICLE Source Type: research

Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro ‐angiogenic properties
Schematic illustration of pro-angiogenic property of calcium phosphate based nanostructures AbstractIn synthetic fabrication, the process parameters decide the growth nucleation, phase translation, and the evolution of morphological facets of nanostructured materials. This work demonstrates the formation of different crystallographic phases of calcium phosphate by the influence of pH from acidic to alkaline conditions and also investigated their bone regeneration, protein adsorption, and pro-angiogenic properties. Present results illustrate that the alteration of pH is the crucial factor for the synthesis of calcium phosph...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 18, 2022 Category: Materials Science Authors: Shalini Thomas, Ajay Rakkesh Rajendran, Balakumar Subramanian Tags: RESEARCH ARTICLE Source Type: research

Polyetherimide ‐ and folic acid‐modified Fe3O4 nanospheres for enhanced magnetic hyperthermia performance
AbstractRecent studies have highlighted the development prospects of magnetic hyperthermia in cancer therapy. A few studies on the application of Fe3O4 nanospheres for the magnetic hyperthermia of gynecological malignancies have achieved certain efficacy, but there was no visible progress currently. In this work, Fe3O4 nanospheres modified with polyetherimide (PEI) and folic acid (FA) were synthesized using a hydrothermal method for possible utility in biocompatible and active tumor-targeting magnetic induction hyperthermia. The PEI- and FA-coated Fe3O4 nanospheres showed high crystallinity, well-dispersed spherical struct...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 17, 2022 Category: Materials Science Authors: Qinganzi Wang, Yuemei Cheng, Wenhua Wang, Xiaolin Tang, Yongxiu Yang Tags: RESEARCH ARTICLE Source Type: research

Resin ‐modified glass ionomer enriched with BIOGLASS: Ion‐release, bioactivity and antibacterial effect
This study aimed to evaluate the physicochemical and microbiological effects of adding 45S5 bioglass to resin-modified glass ionomer cement (RMGIC). Samples belonged to the following groups: GIC: conventional glass ionomer cement (Vitro Fil), RMGIC: resin-modified GIC (Vitro Fil LC), and RMGIC/45S5: RMGIC with 10% (wt  %) of 45S5. Changes in pH and release of fluoride, calcium, and phosphorus ions under acidic (pH 4) and neutral (pH 7) pH conditions were evaluated. Antibacterial activity was verified based on colony-forming units. Material sorption and solubility were analyzed after bacterial exposure. After 2 8 days,...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 16, 2022 Category: Materials Science Authors: F ábia Regina Vieira Oliveira Roma, Tarcisio Jorge Leitão Oliveira, José Bauer, Leily Macedo Firoozmand Tags: RESEARCH ARTICLE Source Type: research

Biomechanical assessment of a novel meniscal scaffold compared to partial meniscectomy: A study on porcine meniscal injury
This study aimed to investigate the appropriate size of scaffold implantation on stress distribution and evaluate its mechanical and biomechanical properties considering hydrolysis. The meniscus acts as a load distribution in the knee, and its biomechanical properties are essential for the development of the PGA scaffold. We established a novel meniscal scaffold, which consists of polyglycolic acid (PGA) covered with L-lactide- ε-caprolactone copolymer (P[LA/CL]). After 4 weeks of hydrolysis, the scaffold had a 7% volume reduction compared to the initial volume. In biomechanical tests, the implantation of scaffolds 20% ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 15, 2022 Category: Materials Science Authors: Shunsuke Sezaki, Shuhei Otsuki, Kuniaki Ikeda, Takashi Ishitani, Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Kaito Nakamura, Masashi Neo Tags: RESEARCH ARTICLE Source Type: research

Bone marrow stromal cells are sensitive to discrete surface alterations in build and post ‐build modifications of bioinspired Ti6Al4V 3D‐printed in vitro testing constructs
This study evaluated the relative contributions of build parameters and post-manufacturing modification techniques to cell responses that impact osseointegration in vivo. Biomimetic testing constructs were created by using a M3D printer with standard titanium –aluminum–vanadium (Ti6Al4V) print parameters. These constructs were treated by either grit-blasting and acid-etching (GB + AE) or GB + AE followed by hot isostatic pressure (HIP) (GB + AE, HIP). Next, nine constructs were created by using a M3D printer with three build parameters: ( 1) standard, (2) increased hatch spacing, and (3) no infill, and addi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 14, 2022 Category: Materials Science Authors: Michael B. Berger, D. Joshua Cohen, Kyle Snyder, John Sions, Barbara D. Boyan, Zvi Schwartz Tags: RESEARCH ARTICLE Source Type: research

An in vitro comparison of human corneal epithelial cell activity and inflammatory response on differently designed ocular amniotic membranes and a clinical case study
This study evaluates the effects of sidedness and processing on human corneal epithelial cell (HCEC) activity, the effect of processing on HCEC inflammatory response, and then a case study is presented. Three differently processed, commercially available ocular AMs were selected: (1) Biovance ®3L Ocular, a decellularized, dehydrated human AM (DDHAM), (2) AMBIO2®, a dehydrated human AM (DHAM), and (3) AmnioGraft®, a cryopreserved human AM (CHAM). HCECs were seeded onto the AMs and incubated for 1, 4 and 7 days. Cell adhesion and viability were evaluated using alamarBlue assay. HCEC m igration was evaluated using a scra...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 13, 2022 Category: Materials Science Authors: Yong Mao, Nicole M. Protzman, Nikita John, Adam Kuehn, Desiree Long, Raja Sivalenka, Radoslaw A. Junka, Anish U. Shah, Anna Gosiewska, Robert J. Hariri, Stephen A. Brigido Tags: RESEARCH ARTICLE Source Type: research

The optimization of PLGA knitted mesh reinforced ‐collagen/chitosan scaffold for the healing of full‐thickness skin defects
This study was conducted to optimize the configuration of PLGA knitted mesh-collagen-chitosan scaffold (PCCS), and explore possible mechanisms. PLGA knitted mesh was embedded in CCS through freeze-drying method. With the PLGA knitted mesh located at the bottom, middle, or both bottom and top layers of the CCS, three kinds of PCCS were developed. A full-thickness skin wound model was established in Sprague Dawley rats to evaluate the therapeutic effects of different PCCS against CCS. The properties and healing effect of the scaffolds were investigated. Several growth factors and chemotactic factors, that is, VEGF, PDGF, CD3...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 12, 2022 Category: Materials Science Authors: Xuanliang Pan, Chuangang You, Pan Wu, Xingang Wang, Chunmao Han Tags: RESEARCH ARTICLE Source Type: research

Similarly low ‐blood metal ion levels at 10‐years follow‐up of total hip arthroplasties with Oxinium, CoCrMo, and stainless steel femoral heads. Data from a randomized clinical trial
AbstractThe use of inert head materials such as ceramic heads has been proposed as a method of reducing wear and corrosion products from the articulating surfaces in total hip arthroplasty, as well as from the stem-head taper connection. The aim of the present study was to compare the blood metal ion levels in patients with Oxinium and CoCrMo modular femoral heads, as well as monoblock stainless steel Charnley prostheses at 10  years postoperatively. The 150 patients with osteoarthritis of the hip joint included in a randomized clinical trial were grouped according to femoral head material. One group (n = 30) had recei...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 11, 2022 Category: Materials Science Authors: Paul Johan H øl, Geir Hallan, Ove Furnes, Anne Marie Fenstad, Kari Indrekvam, Thomas Kadar Tags: RESEARCH ARTICLE Source Type: research

The impact of long ‐term aging in artificial saliva media on resin‐based dental composite strength
AbstractAlthough salivary liquid can degrade constituents in resin-based dental composites in short-term incubations, there is a knowledge gap on how longer-term aging impacts their bulk strength. We address this through extended aging studies with resin-based dental composites in different environments. Two commercial composites (FIL and AEL) were aged aseptically at 37 °C in air (A, control), artificial saliva (AS), and esterase enzyme amended AS (EAS). Diametral and pushout strength were measured after periods of 120–180 days. At 120 days, the diametral strength of composites aged in air was 69.9 ± 11.0 and ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 10, 2022 Category: Materials Science Authors: Karabi Mondal, Evan P. O'Brien, Karl J. Rockne, James L. Drummond Tags: RESEARCH ARTICLE Source Type: research

Similarly low blood metal ion levels at 10 ‐years follow‐up of total hip arthroplasties with Oxinium, CoCrMo, and stainless steel femoral heads. Data from a randomized clinical trial
AbstractThe use of inert head materials such as ceramic heads has been proposed as a method of reducing wear and corrosion products from the articulating surfaces in total hip arthroplasty, as well as from the stem-head taper connection. The aim of the present study was to compare the blood metal ion levels in patients with Oxinium and CoCrMo modular femoral heads, as well as monoblock stainless steel Charnley prostheses at 10  years postoperatively. The 150 patients with osteoarthritis of the hip joint included in a randomized clinical trial were grouped according to femoral head material. One group (n = 30) had recei...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 10, 2022 Category: Materials Science Authors: Paul Johan H øl, Geir Hallan, Ove Furnes, Anne Marie Fenstad, Kari Indrekvam, Thomas Kadar Tags: RESEARCH ARTICLE Source Type: research

The effect of serum proteins on the electrochemical behavior of CoNiCrMo
AbstractNumerous studies have examined the effect of serum and blood proteins on the general corrosion of metallic biomedical materials. However, it is unclear whether proteins have any effect in the case of CoCr alloys, particularly at physiological concentrations. In this work, potentiodynamic polarization and electrochemical impedance spectroscopy were used to investigate the electrochemical behavior of Co-35Ni-20Cr-10Mo in PBS, PBS with albumin at a concentration (36  g/L) representative of serum, and bovine serum. The corrosion current density (icorr) for the CoNiCrMo was changed little by the addition of serum-leve...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 6, 2022 Category: Materials Science Authors: Bruce G. Pound Tags: RESEARCH ARTICLE Source Type: research

Neuronal cell response on aligned fibroporous electrospun mat generated from silver ion complexed ethylene vinyl alcohol copolymer
Neurite extension on aligned fibers fabricated from silver ion complexed Ethylene vinyl alcohol copolymer (EVAL). AbstractGenerating electrospun mats with aligned fibers and obtaining neurite extension in the aligned fiber direction could provide hope for fabricating nerve guidance conduits or wraps through an easy method. The growing interest in generating electrospun mats with aligned fibers for tissue engineering is looking for simple methods to generate the same. Here, in this study, ethylene vinyl alcohol copolymer (EVAL) chains were complexed with silver ions (Ag+) to generate aligned fibers during the electrospinnin...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 5, 2022 Category: Materials Science Authors: Prima Sumam, Ramesh Parameswaran Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - November 1, 2022 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research