Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Conductive polymers for cardiac tissue engineering and regeneration
AbstractCardiovascular diseases, such as myocardial infarction, are considered a significant global burden and the leading cause of death. Given the inability of damaged cardiac tissue to self-repair, cell-based tissue engineering and regeneration may be the only viable option for restoring normal heart function. To maintain the normal excitation-contraction coupling function of cardiac tissue, uniform electronic and ionic conductance properties are required. To transport cells to damaged cardiac tissues, several techniques, including the incorporation of cells into conductive polymers (CPs) and biomaterials, have been uti...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 12, 2023 Category: Materials Science Authors: Parvin Shokrollahi, Yadollah Omidi, Luigi X. Cubeddu, Hossein Omidian Tags: REVIEW ARTICLE Source Type: research

Investigations of hybrid infill pattern in additive manufactured tablets: A novel approach towards tunable drug release
Hybrid infill patterns and their tunable drug release characterstics. AbstractThe significance of 3D printing has risen exponentially in biomedical and pharmaceutical applications. Its potential in the field of fabricating drug delivery systems, by virtue of processing biocompatible polymers, has been very lucrative. This work aims to tap the interstitial drug delivery kinetics that are often inaccessible through machine-specific infill patterns in additive manufactured tablets fabricated using PVA biopolymer as an excipient. In this regard, a myo-inositol containing tablet has been printed using Fused Deposition Modeling ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 10, 2023 Category: Materials Science Authors: R. Durga Prasad Reddy, Varun Sharma Tags: RESEARCH ARTICLE Source Type: research

A composite of polymethylmethacrylate, hydroxyapatite, and β‐tricalcium phosphate for bone regeneration in an osteoporotic rat model
This study suggests that the PHT-3 bio-composite can be a promising candidate for treating osteoporosis-related vertebral fractures. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 9, 2023 Category: Materials Science Authors: Mosharraf Hossain, Je Hoon Jeong, Tamima Sultana, Ju Hyung Kim, Ji Eun Moon, Soobin Im Tags: RESEARCH ARTICLE Source Type: research

Effect of calcium hydrothermal treatment of zirconia abutments on human gingival fibroblasts
AbstractZirconia materials have been increasingly used in implant rehabilitation due to their excellent physical and esthetic properties. Stable peri-implant epithelial tissue adhesion to the transmucosal implant abutment may significantly enhance the efficacy of implant long-term stability. However, it is difficult to form stable chemical or biological bindings with peri-implant epithelial tissue due to the strong biological inertia of zirconia materials. In the present study, we investigated whether calcium hydrothermal treatment of zirconia promotes sealing of peri-implant epithelial tissue. In vitro experiments were pe...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 8, 2023 Category: Materials Science Authors: Dan Zhao, Yanjun Leng, Yishu Liu, Xudiyang Zhou Tags: RESEARCH ARTICLE Source Type: research

Analysis of the adhesive interface of dentine treated with carbodiimide and chitosan before cementation of fiberglass posts with different resin cements
The objective of this study is to evaluate the effect of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and chitosan (CHI) on the adhesive interface of resin cements to root dentine. Forty-five upper canines were sectioned, endodontically treated, prepared and divided into three groups according to dentine treatment (distilled water —DW, CHI 0.2% and EDC 0.5) and in three subgroups according to resin cement: RelyX ARC, Panavia F 2.0 or RelyX U200. Slices were obtained, with five slices of each third submitted to the analysis of the adaptation of the adhesive interface through scores and the perimeter with gaps in c...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 8, 2023 Category: Materials Science Authors: Helena Cristina de Assis, Gunther Ricardo Bertolini, Manoel Dami ão Sousa‐Neto, Fabiane Carneiro Lopes‐Olhê Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 7, 2023 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Picosecond laser ‐induced hybrid groove structures on Ti‐6Al‐4V bio‐alloy to accelerate osseointegration
AbstractRegulating cell growth, extracellular matrix deposition and mineralization of artificial implants are some important parameters that decide the longevity of implants in the body. Picosecond laser-induced hybrid groove structures have been shown to improve these properties of the Ti-6Al-4V bio-alloy. Two hybrid structures containing groove patterns with periodic and non-periodic substructures therein were generated on Ti-6Al-4V by varying the extent of laser pulse overlapping on sample surface. Laser-induced alteration in surface topography, chemical composition and wettability of Ti-6Al-4V resulted in 3-fold increa...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 6, 2023 Category: Materials Science Authors: S. Kedia, R. Checker, S. K. Sandur, J. P. Nilaya Tags: RESEARCH ARTICLE Source Type: research

Enhanced bioactivity and hydrothermal aging resistance of Y ‐TZP ceramics for dental implant
In this study, Y-TZP was prepared by 77S bioactive glass (BG) sol and akermanite (AKT) sol infiltration and microwave sintering, which provided Y-TZP with high bioactivity while maintaining resistance to hydrothermal aging. Results of phase composition evaluation, microstructural characteristics, and mechanical property tests showed that modified Y-TZP specimens exhibited little or no tetragonal-to-monoclinic (t  → m) transformation and maintained relatively high mechanical properties after accelerated hydrothermal aging treatment. The in vitro biological behaviors showed that the introduction of 77S BG and AKT signi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 1, 2023 Category: Materials Science Authors: Qixuan He, Wenmin Zhang, Xiaozhen Zhan, Yanping Qin, Jiandong Ye Tags: RESEARCH ARTICLE Source Type: research

Silymarin modified polysulfone hollow fiber membranes with antioxidant, anti ‐M1 macrophage polarization and hemocompatibility for blood purification
AbstractOxidative stress is highly prevalent in maintenance hemodialysis patients and increases the risk of cardiovascular morbidity and mortality. Silymarin (SM) is a natural compound extracted from plants, and has been shown to have pharmacological effects such as antioxidant, anti-inflammatory, cytoprotective, and anti-nephrotoxicity. SM-modified polysulfone (PSF) hemodialysis membranes were prepared by an immersion-precipitation phase transition method. The experimental results showed that the modified membranes effectively scavenged free radicals, significantly inhibited lipid peroxidation, and had good antioxidant st...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 31, 2023 Category: Materials Science Authors: Peichen Wang, Ning Yang, Ying Luo, Gan Wang, Shuaizhen Zhou, Shuai Huang, Li Chen, Yiping Zhao Tags: RESEARCH ARTICLE Source Type: research

Osteoblast and bacterial cell response on RGD peptide ‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid or a carbon dioxide saturation process. The coatings were deposited using a voltage of 10  V for 1 min. The prepared coatings were examined using SEM, EDS, FTIR, and XPS techniques. In addition, the wettability of these surfaces, corrosion resistance, adhesion of the coatings to the metallic substrate, and their antimicrobial activity (E. coli,S. aureu...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 31, 2023 Category: Materials Science Authors: Łukasz Pawłowski, Szymon Mania, Adrianna Banach‐Kopeć, Michał Bartmański, Anna Ronowska, Kacper Jurak, Aleksandra Mielewczyk‐Gryń, Natalia Karska, Sylwia Rodziewicz‐Motowidło, Andrzej Zieliński Tags: RESEARCH ARTICLE Source Type: research

Pharmacokinetics and repeated dose 28 ‐day oral toxicity studies of acetaminophen nanosuspension
In this study, an attempt was made to improve oral bioavailability and reduce the toxicity of acetaminophen using nanosuspension technology. The acetaminophen nanosuspensions (APAP-NSs) were prepared by a nano-precipitation method using polyvinyl alcohol and hydroxypropylmethylcellulose as stabilizers. The mean diameter of APAP-NSs was 124  ± 3.8 nm. The dissolution profile of APAP-NSs was significantly point-to-point higher than the coarse drug in simulated gastrointestinal fluids. The in vivo study revealed 1.6- and 2.8-fold increases in the AUC0-inf and Cmax of the drug, respectively, in APAP-NSs-receiving animal...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 29, 2023 Category: Materials Science Authors: Zahra Karami, Sepideh Arbabi Bidgoli, Mohammadreza Saghatchi Zanjani, Peyman Arabshahi, Taraneh Gazori, Mehrdad Hamidi Tags: RESEARCH ARTICLE Source Type: research

Bioactive impact of manuka honey and bone char incorporated into gelatin and chitosan cryogels in a rat calvarial fracture model
AbstractBone tissue engineered scaffolds are designed to mimic the natural environment for regeneration when typical healing is inhibited. Autografts are the current gold standard for treatment but are limited by available bone and supplementary surgical sites that broaden complications and comorbidities. Cryogels are an ideal scaffold in bone regeneration due to their mechanical integrity and marcoporous structure that elicits angiogenesis and subsequently new bone tissue formation. To aid in bioactivity and osteoinductivity, manuka honey (MH) and bone char (BC) were added to gelatin and chitosan cryogels (CG). Manuka hon...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 27, 2023 Category: Materials Science Authors: E. M. Robertson, K. R. Hixon, S. H. McBride ‐Gagyi, S. A. Sell Tags: RESEARCH ARTICLE Source Type: research

Analysis of stress/strain distribution in dental mini ‐implants manufactured by additive manufacturing and machining
AbstractThe study aimed to analyze the stress/strain distribution of new designs of mini-implants manufactured by machining and additive manufacturing. Four designs were evaluated ( Ø2.0 mm × 10 mm): Intra-lock, helical, threaded machined (MN threaded) and threaded by additive manufacturing (AM threaded). Analysis of stress was performed through photoelastic analysis (100 N axial/oblique loads) and analysis of strain by digital image correlation (DIC) (250 N axial /100 N oblique load). Data distribution was verified using the Shapiro–Wilk test and a significance level of 5% was adopted. Quantitative data ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 23, 2023 Category: Materials Science Authors: Thaisa Theodoro Oliveira, Mariana Lima da Costa Valente, Isadora Gazott Sim ões, Rodolfo Lisboa Batalha, Ana Paula Macedo, Claudemiro Bolfarini, Simon Pauly, Andréa Cândido Reis Tags: RESEARCH ARTICLE Source Type: research

Natural 3D Extra Cellular Matrix mimicking stem cells seeded decellularized scaffolds as a platform for tendon regeneration
Schematic representation of the development of scaffolds for tendon tissue engineering applications. AbstractAchilles tendon, which connects the calf muscles to heel, is the strongest tendon in the body. Despite its strength, it is more prone to injury due to its limited blood supply. Tendon-related injuries are more common in sportspersons, people with labor-intensive work and the aged community. The currently available treatment mode is surgery which is expensive with chances of re-injury. Present study made an attempt to fabricate a tissue-engineered tendon product using decellularized tendon (DT) seeded with stem cells...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 20, 2023 Category: Materials Science Authors: K. Niveditha, Annie John, Josna Joseph, S. Mini, C. A. Vineeth, T. S. Swapna, Annie Abraham Tags: RESEARCH ARTICLE Source Type: research

Osteogenic differentiation of mesenchymal stem cells cultured on allogenic trabecular bone grafts treated with high hydrostatic pressure
AbstractThe requirements for bone substitute materials are multifaceted. Beside biomechanical stability, these materials should provide osteoconductive and osteoinductive properties to promote integration into the host tissue. So far, autologous bone is the only material, which combines all properties, but is naturally limited. Allogenic bone grafts have to be decellularized prior to implantation. This causes the reduction of biomechanical properties and the loss of osteoinductive qualities. High hydrostatic pressure (HHP) offers a gentle alternative for processing and supply of allogenic bone substitute materials while pr...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 19, 2023 Category: Materials Science Authors: Janine Waletzko ‐Hellwig, Michael Dau, Vivien Krebs, Rainer Bader Tags: RESEARCH ARTICLE Source Type: research