Hydroxyapatite ‐based dental inserts: Microstructure, mechanical properties, bonding efficiency and fracture resistance of molars with occlusal restorations
In conclusion, HA P-based dental inserts may potentially replace dentin in large cavities, without affecting fracture resistance of restored teeth. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 4, 2023 Category: Materials Science Authors: Tamara Matic, Maja Lezaja Zebic, Vesna Miletic, Isaak Trajkovic, Milos Milosevic, Aleksandar Racic, Djordje Veljovic Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 4, 2023 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Recent advances in glass ‐ceramics: Performance and toughening mechanisms in restorative dentistry
AbstractThe use of glass-ceramics in the medical field has grown significantly since the 1980s. With excellent aesthetic properties, semi-translucency, outstanding mechanical properties, corrosion resistance, wear resistance and great biocompatibility and workability glass-ceramics is one of the most commonly used materials in restorative dentistry and is widely used in veneers, inlays, onlays, all-ceramic crowns, and implant abutments. This review provides an overview of the research progress of glass-ceramics in restorative dentistry, focusing on the classification, performance requirements, toughening mechanisms and the...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 30, 2023 Category: Materials Science Authors: Xiaoming Liu, Xuemin Yao, Ran Zhang, Lingxiang Sun, Zheyuan Zhang, Yifan Zhao, Tong Zhang, Jingyu Yan, Yanjie Zhang, Xiuping Wu, Bing Li Tags: REVIEW ARTICLE Source Type: research

The effect of supplementing the calcium phosphate cement containing poloxamer 407 on cellular activities
In this study, the poloxamer addition effects (0.05 and 0.1 g/mL) on the cellular activities of MC3T3-E1 cells cultured in vitro were investigated. The ce ll viability of mβ-TCP containing poloxamer 407 was similar to that of mβ-TCP. All specimens showed effective cell attachment and healthy polygonal extension of the cytoplasm firmly attached to hydroxyapatite (HA) crystals. Therefore, even with the addition of poloxamer to mβ-TCP, it does not hav e a negative effect to osteoblast growth. These data demonstrated that the addition of poloxamer 407 to mβ-TCP might be considered a potential therapeutic application for ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 29, 2023 Category: Materials Science Authors: Yeeun Kim, Kenichi Hamada, Kazumitsu Sekine Tags: RESEARCH ARTICLE Source Type: research

Microscopic in ‐situ analysis of the mucosal healing around implants treated by protease activated receptor 4‐agonist peptide or perpendicularly protruded type I collagen in rats
AbstractEnhanced mucosal sealing around titanium implants can reduce complications such as peri-implantitis. The present study aims to investigate the mucosal healing at the early stage around the protease activated receptor 4-agonist peptide (PAR4-AP)- or perpendicularly protruded type I collagen (pCol)-treated titanium implants. A total of 72 implants were placed in 36 rats in the study. Following extractions, two tissue-level implants among the following three different surfaces, PAR4-AP-coated (PAR4 group,n = 24), pCol-treated (pCol group,n = 24) and non-treated (control group,n = 24) ones, were placed in t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 23, 2023 Category: Materials Science Authors: Young Woo Song, Shogo Maekawa, Keito Sasaki, Daichi Yoshida, Masazumi Nagai, Shigemi Ishikawa ‐Nagai, John Da Silva, David Minjoon Kim, Chia‐Yu Chen Tags: RESEARCH ARTICLE Source Type: research

Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction ‐based process and osteogenic in vivo responses
AbstractThree-dimensional macroporous titanium –aluminum–vanadium (TiAl6V4) implants produced by additive manufacturing (AM) can be grit blasted (GB) to yield microtextured exterior surfaces, with additional micro/nano-scale surface features provided by subsequent acid etching (AE). However, the line-of-sight nature of GB causes the topograp hy of exterior GB + AE-modified surfaces to differ from internal GB-inaccessible surfaces. Previous in vitro studies using dense TiAl6V4 substrates indicated that a nonline-of-sight, calciothermic-reaction (CaR)-based process provided homogeneous osteogenic nanotextures on GB...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 22, 2023 Category: Materials Science Authors: Michael B. Berger, D. Joshua Cohen, Jingyao Deng, Pavan Srivas, Barbara D. Boyan, Kenneth H. Sandhage, Zvi Schwartz Tags: RESEARCH ARTICLE Source Type: research

Influence of polylactide coating stereochemistry on mechanical and in vitro degradation properties of porous bioactive glass scaffolds for bone regeneration
In this study, we coated porous bioactive glass 13 –93 scaffolds with amorphous, homocrystalline, or stereocomplex PLA to investigate their mechanical and degradation properties before and after immersion in simulated body fluid. The glass scaffolds had interconnected pores and an average porosity of 76%. The PLA coatings, which were 10–100 μ m thick and approximately 3% of the glass scaffold mass, covered the glass to a large extent. The compressive strength and toughness of all PLA-coated scaffolds were significantly higher than those of uncoated scaffolds, with approximately a fourfold increase before immersion a...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 22, 2023 Category: Materials Science Authors: Peter Uppstu, Simon Engblom, Saara Inkinen, Leena Hupa, Carl ‐Eric Wilén Tags: RESEARCH ARTICLE Source Type: research

Enhancing near ‐infrared fluorescence intensity and stability of PLGA‐b‐PEG micelles by introducing Gd‐DOTA at the core boundary
In conclusion, we found that overall fluorescence and stability are improved by introducing Gd-DOTA at the boundary of the PLGA core and PEG shell. Improving micelle stability is crucial for further biomedical applications of micellar probes such as bimodal fluorescence and magnetic resonance imaging. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 22, 2023 Category: Materials Science Authors: Thi Kim Dung Doan, Masakazu Umezawa, Kyohei Okubo, Masao Kamimura, Kohei Soga Tags: RESEARCH ARTICLE Source Type: research

Cytocompatibility, antibacterial, and corrosion properties of chitosan/polymethacrylates and chitosan/poly(4 ‐vinylpyridine) smart coatings, electrophoretically deposited on nanosilver‐decorated titania nanotubes
This study involved different surface treatments of titanium surface, mainly by electrochemical oxidation to produce a nanotubular oxide layer (TNTs), a subsequent electrochemical reduction of silver nitrate and decoration of a nanotubular surface with silver nanoparticles (AgNPs), and finally electrophoretic deposition (EPD) of a composite of chitosan (CS) and either polymethacrylate-based copolymer Eudragit E 100 (EE100) or poly(4-vinylpyridine) (P4VP) coating. The effects of each stage of this multi-step modification were examined in terms of morphology, roughness, wettability, corrosion resistance, coating-substrate ad...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 21, 2023 Category: Materials Science Authors: Łukasz Pawłowski, Michał Bartmański, Anna Ronowska, Adrianna Banach‐Kopeć, Szymon Mania, Bartłomiej Michał Cieślik, Aleksandra Mielewczyk‐Gryń, Jakub Karczewski, Andrzej Zieliński Tags: RESEARCH ARTICLE Source Type: research

Characterization and biological evaluation of a novel flavonoid ‐collagen antioxidant hydrogel with cytoprotective properties
AbstractReactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub-optimal healing. Minimizing oxidative damage to the wound site and any supplemental therapeutic cells can be achieved by delivering exogenous antioxidants. Collagen hydrogels are ideal wound care materials due to their biocompatibility, high water content, and porous, three-dimensional architecture. Yet, they lack the inherent antioxidant activity that could help mitigate excess ROS at a wound site. This work formulates and evaluates the in vitro biocompatibility...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 17, 2023 Category: Materials Science Authors: Danielle M. Nalband, Prottasha Sarker, Saad A. Khan, Donald O. Freytes Tags: RESEARCH ARTICLE Source Type: research

pH ‐responsive resveratrol‐loaded ZIF‐8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy . By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 14, 2023 Category: Materials Science Authors: Xueqiang Sun, Fuxin Li, Lingyan Yuan, Zhitong Bing, Xun Li, Kehu Yang Tags: RESEARCH ARTICLE Source Type: research

Development of hydrogel ‐based composite scaffolds containing eggshell particles for bone regeneration applications
This study describes the development and characterization of novel composite scaffolds, made of an alginate-chitosan hydrogel matrix containing eggshell (ES) particles, for bone tissue engineering applications. Scaffolds with ES particles, either untreated or treated with phosphoric acid to create a nanotextured particle surface, were compared to scaffolds without particles. Results indicate that the nanotexturing process exposed occluded ES proteins orthologous to those in human bone extracellular matrix. Scaffolds with ES or nanotextured ES (NTES) particles had a higher porosity (81  ± 4% and 89 ± 5%, respectiv...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 13, 2023 Category: Materials Science Authors: Nicholas D. Calvert, Scott Proulx, Alejandro Rodriguez ‐Navarro, Tamer Ahmed, Eric A. Lehoux, Maxwell T. Hincke, Isabelle Catelas Tags: RESEARCH ARTICLE Source Type: research

Physicochemical, in vitro and in vivo evaluation of VEGF loaded PCL ‐mPEG and PDGF loaded PCL‐Chitosan dual layered vascular grafts
AbstractThe present study has attempted to evaluate the endothelialization and smooth muscle regeneration efficiency of a novel dual-layer small-diameter vascular graft. Two types of layers (PCL-mPEG-VEGF and PCL-Chitosan-PDGF) were fabricated to find out the best layer giving endothelialization support for the lumen and unique contractile function for outer layer of blood vessels. Platelet-derived growth factor (PDGF) and chitosan were immobilized onto PCL surface by aminolysis-based surface modification technique. Besides, Poly (ethylene glycol) methyl ether (mPEG) and vascular endothelial growth factor (VEGF) were direc...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 8, 2023 Category: Materials Science Authors: Tamanna Sultana, Md. Abdullah Al Fahad, Myeongki Park, Soon Ha Kwon, Byong ‐Taek Lee Tags: RESEARCH ARTICLE Source Type: research

Development of a novel PLDLA/ β‐TCP composite‐based biodegradable anterior cervical plate and screw system
AbstractWe investigated the effectiveness and safety of a new composite-based biodegradable anterior cervical plate/screw (ACPS) system for the anterior cervical discectomy and fusion (ACDF) fixation. A biocomposite in combination with 30  wt% β-tricalcium phosphate (β-TCP; a biodegradable ceramic having osteoconductive ability) and 70 wt% poly-l/d-lactide copolymer (PLDLA; a biodegradable polymer) was developed and used in the ACPS device, comprising one plate and four screws for fixation. Based on a literature review, a clinically required period of performance maintenance was set as 16  weeks, and to verify the ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 6, 2023 Category: Materials Science Authors: Younghoon Kwon, Mosharraf Hossain, Minsu Lee, Je Hoon Jeong Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 1, 2023 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research