Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

3D printed wound constructs for skin tissue engineering: A systematic review in experimental animal models
AbstractWound dressings are one of the most used treatments for chronic wounds. Moreover, 3D printing has been emerging as a promising strategy for printing 3D printed wound constructs, being able of manufacturing multi layers, with a solid 3D structure. Although all these promising effects of 3D printed wound constructs, there is still few studies and limited understanding of the interaction of these dressings with skin tissue and their effect on the process of skin wound healing. In this context, the aim of this work was to perform a systematic review of the literature to examine the effects of 3D printed wound construct...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 26, 2023 Category: Materials Science Authors: Amanda Souza, Cintia Cristina Santi Martignago, Giovanna do Espirito Santo, Karolyne dos Santos Jorge Sousa, Matheus Almeida Cruz, Gustavo Oliva Amaral, Julia Risso Parisi, D ébora Estadella, Daniel Araki Ribeiro, Renata Neves Granito, Ana Clau Tags: REVIEW ARTICLE Source Type: research

Biological properties of hydroxyapatite coatings on titanium dioxide nanotube surfaces using negative pressure method
In this study, porous titanium dioxide nanotube arrays were prepared on Ti surface by anodic oxidation, loaded with calcium and phosphorus precursors by negative pressure immersion, and HA coating was formed by in situ crystallization of calcium and phosphorus on the surface by hydrothermal heating. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and bonding strength were conducted to confirm the surface characteristics of each group. The cell proliferation, mineralization degree, and alkaline phosphatase (ALP) activity of MC3T3-E1 cells on samples were calculated and compared in vitro experiments. Cylindrical...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 25, 2023 Category: Materials Science Authors: Yan Wang, Shuang Tang, Ning Ding, Zutai Zhang Tags: RESEARCH ARTICLE Source Type: research

3D ‐Printed conductive polymeric scaffolds with direct current electrical stimulation for enhanced bone regeneration
This study demonstrates the potential for low-cost, conductive scaffolding materials to support cell viability and enhance in vitro mineraliz ation in conjunction with ES. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 24, 2023 Category: Materials Science Authors: Damion T. Dixon, Cheryl T. Gomillion Tags: RESEARCH ARTICLE Source Type: research

A porous swelling copolymeric material for improved implant fixation to bone
AbstractMost metallic commercial bone anchors, such as screws and suture anchors achieve their fixation to bone through shear of the bone located between the threads. They have several deficiencies, potentially leading to failure, which are particularly evident in low-density bone. These include stress-shielding resulting from mechanical properties mismatch; lack of mechanically induced remodeling and osteointegration; and when the pullout force on the anchor, during functional activities, exceeds their pullout strength, catastrophic failure occurs leaving behind large bone defects that may be hard to repair. To overcome t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 24, 2023 Category: Materials Science Authors: Sorin Siegler, Moein Taghvaei, Ryan Zegarski, Giuseppe Palmese, Rena Mathew, Julia Schayes, Thomas Schaer, Ahmad Najafi Tags: RESEARCH ARTICLE Source Type: research

Study on the preparation and properties of acellular matrix from the skin of silver carp (Hypophthalmichthys molitrix)
In this study, an acellular matrix with low DNA and endotoxin was prepared from the skin of silver carp. After treatment with trypsin/sodium dodecyl sulfate and Triton X-100 solutions, the DNA content in SC-AFSM reached 11.03  ± 0.85 ng/mg, and the endotoxin removal rate was 96.8%. The porosity of SC-AFSM was 79.64% ± 0.17%, which is favorable for cell infiltration and proliferation. The relative cell proliferation rate of SC-AFSM extract was 117.79% ± 15.26%. The wound healing experiment showed that SC- AFSM had no adverse acute pro-inflammatory response, which had a similar effect as commercial products ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 22, 2023 Category: Materials Science Authors: Zeyu Wei, Junjie Zhang, Zhiwen Guo, Zhiming Wu, Yaru Sun, Ke Wang, Rui Duan Tags: RESEARCH ARTICLE Source Type: research

Physical, morphological and bioactive properties of Co –Cr–W–Ta alloys: Influence of insertion of tantalum and surface thermochemical treatment on bioactivity
AbstractThe development of bioactivity in bioinert metallic alloys is a field of interest aiming to improve some aspects of these materials for implant applications. New Co63Cr28W9-xTax alloys with different Ta concentrations (x = 0, 2, 4, 6, and 9% w/w) were synthesized in the work reported here. The alloys were characterized by x-ray diffraction, volumetric density, Vickers microhardness, atomic force microscopy, scanning electron microscopy (SEM), and energy-dispersion x-ray spectroscopy (EDS). Bioactivity properties were evaluated by in vitro tests with simulated body fluid (SBF). In vivo assays were performed to ass...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 14, 2023 Category: Materials Science Authors: Beatriz da Silva Batista, Luzeli Moreira da Silva, Alan Silva de Menezes, Luana Barbosa Corr êa, Elaine Cruz Rosas, Ralph Santos‐Oliveira, Fernando Mendes, Ana Angélica M. Macêdo, Luciana M. Rebelo Alencar Tags: RESEARCH ARTICLE Source Type: research

The effect of alginate scaffolds on bone healing in defects formed with drilling model in rat femur diaphysis
AbstractAlginate (ALG) is a biocompatible and biodegradable polymer. Mechanical weakness is one of the main problems for the alginate-based scaffolds. Various plasticizer additives or modifications tested to improve the mechanical properties. In the presented study, ALG plasticized with triacetin (TA), and tributyl citrate (TBC) than tested on bone healing. In the presented study, the alginate modified with triacetin or tributyl citrate. In-vitro, and in-vivo efficiency of the scaffolds tested on bone tissue regeneration. Scaffolds fabricated by solvent casting, and physicochemical characterizations performed. Monocytes (T...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 14, 2023 Category: Materials Science Authors: Arslan Kagan Arslan, Ali Aydo ğdu, Tolga Tolunay, Çağdaş Basat, Resul Bircan, Murat Demirbilek Tags: RESEARCH ARTICLE Source Type: research

Optimizing the combined soft tissue repair and osteogenesis using double surfaces of crosslinked collagen scaffolds
This study determined whether the double surfaces of crosslinked collagen scaffolds could optimize the combined soft tissue repair and osteogenesis. In this study, we applied the chemically crosslinking treatment to the commercially available collagen scaffolds. Surface characterization, mechanical property and cell proliferation in vitro were evaluated. Combined bilateral skin and bone defects were established with the smooth surface of scaffold facing the skin defect and the rough surface facing the bone defect on the calvaria of rat. Micro-CT and histological evaluation were applied to determine the scaffold degradation...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 14, 2023 Category: Materials Science Authors: Zhengchuan Zhang, Qifen He, Jinhao Zhu, Xiaoxuan Lin, Yang Yang, Hongcheng Chen, Xiaoqiong Huang, Ruogu Xu, Feilong Deng Tags: RESEARCH ARTICLE Source Type: research

In vitro elution characteristics of antibiotic ‐loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant‐associated infections
In conclusion, in the present study, both PG-CSH and PMMA beads acted as good carriers, but greater antimicrobial elution and biofilm bacterial killing were observed with PG-CSH than PMMA. Future in vitro research should focus on testing other difficult-to-treat clinical strains, including multidrug resistant coagulase-negativestaphylococci and Gram-negative bacilli. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 13, 2023 Category: Materials Science Authors: Laura Batista Campos, Mariana Neri Lucas Kurihara, Ingrid Nayara Marcelino Santos, Fernando Baldy Reis, Mauro Jos é Salles Tags: RESEARCH ARTICLE Source Type: research

Copper ‐deposited diatom‐biosilica enhanced osteogenic potential in periodontal ligament stem cells and rat cranium
This study aimed to establish that copper-deposited Diatom-biosilica have the potential and possibility for clinical applications in repairing bone defects in a state of inflammation, such as periodontitis. Treatment of alveolar bone defects caused by periodontitis is a major challenge for clinicians. To achieve better repair results, the material should not only be bone conductive but also have the ability to stimulate osteogenesis and angiogenesis at the lesion site. Copper (II) and silicon (IV) ions could react to form basic copper silicate, which promoted both osteogenesis and angiogenesis. The mineralized diatom (Cu-D...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 12, 2023 Category: Materials Science Authors: Xu Qiu, Chao Feng, Wenxuan Wang, Guangsheng Wu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Xiguang Chen, Qiuxia Ji Tags: RESEARCH ARTICLE Source Type: research

Niobium ‐containing bioactive glasses modulate alkaline phosphatase activity during bone repair
This study aimed to evaluate the pre-clinical behavior of niobium-containing bioactive glasses (BAGNb) by their ability to promote bone repair and regulate alkaline phosphatase (ALP) levels in an animal model. BAGNbs were produced as powders and as scaffolds and surgically implanted in the femur of male rats (Wistar lineagen = 10). Glasses without Nb (BAG) were produced and implanted as well. The Autogenous Bone (AB) was used as a control. After 15, 30, and 60 days of surgical implantation, blood serum samples were collected to quantify ALP activity, and femurs were removed to assess bone repair. Bone samples were hist...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 11, 2023 Category: Materials Science Authors: Gabriela Souza Balbinot, Vicente Castelo Branco Leitune, Eduardo Antunes Cunha Bahlis, Deise Ponzoni, Fernanda Visioli, Fabr ício Mezzomo Collares Tags: RESEARCH ARTICLE Source Type: research

Effect of rare earth oxide microparticles on mechanical, corrosion, antibacterial, and hemolytic behavior of Mg ‐Hydroxyapatite composite for orthopedic applications – A preliminary in‐vitro study
AbstractThe current study focused on developing a multifunctional Mg-based biodegradable composite that mitigates the trade-off between strength, antibacterial, and cytotoxicity behavior for orthopedic bone implants. The composite has been reinforced with natural mineral-based Hydroxyapatite and rare earth oxide (REO): Neodymium oxide. The effect of different concentrations of REO on the mechanical, antibacterial, and corrosion properties was analyzed. The antibacterial properties were assessed against gram-positiveB. Subtilis and gram-negativeE. Coli bacterial pathogens. Moreover, the cytotoxicity of the composites was as...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 11, 2023 Category: Materials Science Authors: Divyanshu Aggarwal, Vinod Kumar, Siddharth Sharma Tags: RESEARCH ARTICLE Source Type: research

The influences of PEG ‐functionalized graphdiyne on cell growth and osteogenic differentiation of bone marrow mesenchymal stem cells
In this study, GDY was modified with polyethylene glycol (PEG) and the influences of GDY-PEG at different concentrations on BMSCs cell growth and osteogenic differentiation were researched for the first time. In this study, we found that GDY-PEG at low concentration possessed premium bio-compatibility and revealed evident facilitation of BMSCs osteogenic differentiation. The cell growth and osteogenic differentiation of BMSCs treated with GDY-PEG were dose-dependent. GDY-PEG at 1  μg/mL demonstrated the optimal promoting effects of BMSCs osteogenic differentiation. Moreover, the regulating effect of BMSCs osteogenic diff...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 11, 2023 Category: Materials Science Authors: Yiming Li, Ziqing Huang, Xiaoqiong Huang, Ruogu Xu, Yi He, Feilong Deng, Guanhui Chen Tags: RESEARCH ARTICLE Source Type: research

The detection of the captured circulating tumor cells on the core ‐shell nanofibrous membrane using hyaluronic acid‐functionalized graphene quantum dots
Detection of cancer cells captured on the electrospun NFM via CD44 receptors- hyaluronic acid interactions used for both entrapments of cells and recognition step using GQD-HA. AbstractIn recent years, cancerous cases have increased remarkably worldwide, and metastasis is the leading cause of death. Therefore, research on the early detection of cancer and metastasis has expanded to aid successful cancer treatment. Here in this paper, at the first step, an electrospun nanofibrous membrane (NFM) with a core-shell structure was fabricated from PCL and HA to achieve cancer cell capturing (about 75% of cells). On the other hand...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 3, 2023 Category: Materials Science Authors: Sahar Asghari, Matin Mahmoudifard Tags: RESEARCH ARTICLE Source Type: research

Property and biological effects of the cuttlebone derived calcium phosphate particles, a potential bioactive bone substitute material
AbstractCuttlebone (CB) is a marine waste-derived biomaterial and a rich source of calcium carbonate for the biosynthesis of the calcium phosphate (CaP) particles. The current study aimed to synthesize CB derived biphasic calcium phosphate (CB-BCP) and investigate biological activity of the CB-CaP: hydroxyapatite (CB-HA), beta-tricalcium phosphate (CB-b-TCP) and biphasic 60:40 (w/w) HA/b-TCP (CB-BCP) with the human dental pulp stem cells (hDPSCs). The particles were synthesized using solid state reactions under mild condition and properties of the particles were compared with a commercial BCP as a reference material. Morph...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 1, 2023 Category: Materials Science Authors: Thanin Tangsuksant, Sarute Ummartyotin, Thirawudh Pongprayoon, Premjit Arpornmaeklong, Komsan Apinyauppatham Tags: RESEARCH ARTICLE Source Type: research