Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of the impact of pH of the reaction mixture, type of the stirring, and the reagents' concentration in the wet precipitation method on physicochemical properties of hydroxyapatite so as to enhance its biomedical application potential
AbstractHydroxyapatite (HAp) constitutes a significant inorganic compound which due to its osteoinductivity, osteoconductivity as well as the ability to promote bone growth and regeneration is widely applied in development of biomaterials designed for bone tissue engineering. In this work, various synthesis methodologies of HAp based on the wet precipitation technique were applied, and the impact of pH of the reaction mixture, the concentration of individual reagents as well as the type of stirring applied (mechanical/magnetic) on the properties of final powders was discussed. Spectroscopic methods (Fourier transform infra...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 11, 2022 Category: Materials Science Authors: Magdalena G łąb, Sonia Kudłacik‐Kramarczyk, Anna Drabczyk, Aleksandra Kordyka, Marcin Godzierz, Paweł S. Wróbel, Agnieszka Tomala, Bożena Tyliszczak, Agnieszka Sobczak‐Kupiec Tags: RESEARCH ARTICLE Source Type: research

Development of branched polyphenolic poly(beta amino esters) to facilitate post ‐synthesis processing
AbstractGiven their versatility and formability, polymers have proven to be a viable platform facilitating a controlled and tuned release for a variety of therapeutic agents. One growing area of polymer drug delivery is polymeric prodrugs, which covalently link active pharmaceutical ingredients to a polymeric form to enhance stability, delivery, and pharmacology. One such class of polymeric prodrugs, poly(beta amino esters) (P βAEs) can be synthesized into crosslinked, or “thermoset,” networks which greatly limits their processability. An antioxidant-PβAE polymer prodrug that is soluble in organic solutions would per...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 11, 2022 Category: Materials Science Authors: Kelley Wiegman, Nicolas J. Briot, J. Zach Hilt, Aron J. Huckaba, Thomas D. Dziubla Tags: RESEARCH ARTICLE Source Type: research

Improved oxidation stability and crosslink density of chemically crosslinked ultrahigh molecular weight polyethylene using the antioxidant synergy for artificial joints
Hybrid VE and DS synergistically enhance the oxidative stability of chemically crosslinked UHMWPE and maintain higher crosslink density than single VE. AbstractVitamin E (VE) is currently an approved antioxidant to improve the oxidation stability of highly crosslinked ultrahigh molecular weight polyethylene (UHMWPE) insert used commercially in total joint arthroplasty. However, the decrease in crosslink density caused by VE reduces wear resistance of UHMWPE, showing an uncoordinated challenge. In this work, we hypothesized that D-sorbitol (DS) as a secondary antioxidant can improve the antioxidant efficacy of VE on chemica...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 9, 2022 Category: Materials Science Authors: Nouman Ali Shah, Ri ‐Tong Lan, Rui Dai, Kai Jiang, Hui‐Yuan Shen, Rui Hong, Jia‐Zhuang Xu, Lingli Li, Zhong‐Ming Li Tags: RESEARCH ARTICLE Source Type: research

Spinal cord decellularized matrix scaffold loaded with engineered basic fibroblast growth factor ‐overexpressed human umbilical cord mesenchymal stromal cells promoted the recovery of spinal cord injury
In this study, we constructed porcine spinal cord decellularized matrix scaffold (SC-DM) with biocompatibility to load engineered basic fibroblast growth factor-overexpressing human umbilical cord mesenchymal stromal cells (bFGF-HUCMSCs) for treating SCI. The continuously released bioactive bFGF factors from grafted bFGF-HUCMSCs and three-dimensional niche by SC-DM promoted the differentiation of endogenous stem cells into neurons with nerve conduction function, leading a markedly motor function recovery of SCI. These results indicated that the functional bFGF-HUCMSCs/SC-DM scaffold provided more suitable matric niche for ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 8, 2022 Category: Materials Science Authors: Wenli He, Chunying Shi, Jia Yin, Feifei Huang, Wenjing Yan, Jin Deng, Bing Zhang, Bin Wang, Haiping Wang Tags: RESEARCH ARTICLE Source Type: research

Laser ‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation
AbstractThis paper presents the results of an experimental and computational study of the effects of laser-induced heating provided by magnetite nanocomposite structures that are being developed for the localized hyperthermic treatment of triple-negative breast cancer. Magnetite nanoparticle-reinforced polydimethylsiloxane (PDMS) nanocomposites were fabricated with weight percentages of 1%, 5%, and 10% magnetite nanoparticles. The nanocomposites were exposed to incident Near Infrared (NIR) laser beams with well-controlled powers. The laser-induced heating is explored in: (i) heating liquid media (deionized water and cell g...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 8, 2022 Category: Materials Science Authors: Chinyerem E. Onyekanne, Ali A. Salifu, John D. Obayemi, Chukwuemeka J. Ani, Habibeh Ashouri Choshali, Chukwudalu C. Nwazojie, Killian C. Onwudiwe, Josephine C. Oparah, Theresa C. Ezenwafor, Chukwudi C. Ezeala, Olushola S. Odusanya, Nima Rahbar, Tags: RESEARCH ARTICLE Source Type: research