Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of a modified adhesive system with encapsulated arginine and calcium carbonate on dentin permeability
AbstractTo modify an adhesive system with halloysite clay nanotubes (HNTs) containing arginine and calcium carbonate and to evaluate their cytocompatibility, viscosity and efficacy in reducing dentin permeability. HNTs containing arginine and calcium carbonate were incorporated into the primer and adhesive of a three-step adhesive system (SBMP), and their viscosity was measured. Discs (n = 4/group) were prepared: SBMP (control), HNT-PR (modified primer), HNT-ADH (modified adhesive) and HNT-PR + ADH (modified primer and adhesive) were evaluated regarding cell death and viability. Dentin discs were prepared and random...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 27, 2023 Category: Materials Science Authors: Aram Mushabbab AlShehri, Krzysztof Kamocki, Ítallo Emídio Lira Viana, Taís Scaramucci, Anderson Hara, L. Jack Windsor, Jeffrey A. Platt, Norman Blaine Cook, Sabrina Feitosa Sochacki Tags: RESEARCH ARTICLE Source Type: research

Crosslinkable fluorophenoxy ‐substituted poly[bis(octafluoropentoxy) phosphazene] biomaterials with improved antimicrobial effect and hemocompatibility
In this study, two additional fluorinated polyphosphazenes (PPs, defined as LS02 and LS03) with fluorophenoxy-substituted side groups, 4-fluorophenoxy and 4-(trifluoromethyl)phenoxy, respectively, based on X-OFP general structure, were synthesized and applied as coatings on stainless steel. The linkage of fluorophenoxy groups to the P-N backbone of PPs was found to increase the surface stiffness and significantly reduced Staphylococcus bacterial adhesion and inhibited biofilm formation. It also significantly reduced microbial infection compared to OFP, our prior X-OFPs or poly[bis(trifluoroethoxy) phosphazene] (TFE). The b...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 25, 2023 Category: Materials Science Authors: Shelby Alwine, Chen Chen, Lihui Shen, Harry R. Allcock, Christopher A. Siedlecki, Li ‐Chong Xu Tags: RESEARCH ARTICLE Source Type: research

Friction reducing ability of a poly ‐l‐lysine and dopamine modified hyaluronan coating for polycaprolactone cartilage resurfacing implants
AbstractFrictional properties of cartilage resurfacing implants should be sufficiently low to limit damaging of the opposing cartilage during articulation. The present study determines if native lubricious molecule proteoglycan 4 (PRG4) can adsorb onto a layer-by-layer bioinspired coating composed of poly-l-lysine (PLL) and dopamine modified hyaluronic acid (HADN) and thereby can reduce the friction between implant and articular cartilage. An ELISA was developed to quantify the amount of immobilized human recombinant (rh)PRG4 after exposure to the PLL-HADN coating. The effect on lubrication was evaluated by comparing the c...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 24, 2023 Category: Materials Science Authors: A. H. A. Damen, C. C. Donkelaar, P. K. Sharma, H. Wan, R. Cardinaels, T. A. Schmidt, K. Ito Tags: RESEARCH ARTICLE Source Type: research

Simple bio ‐inspired coating of ureteral stent for protein and bacterial fouling and calcium encrustation control
In this study, commercial ureteral stent was coated with polydopamine (PDA), formed from self-polymerization of dopamine. The PDA coating was optimized in terms of dopamine concentration, pH, and coating time using response surface methodology. The chosen response parameters for optimization were calcium oxalate (CaC2O4) encrustation and protein adsorption. Optimized PDA coating conditions were determined to be the following: pH  9.0, 2 mg/mL DA, and 3 days coating. The optimized PDA-coated ureteral stent exhibited outstanding resistance against CaC2O4 encrustation, protein fouling, and bacterial adhesion due to its hy...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 21, 2023 Category: Materials Science Authors: Ralph Rolly Gonzales, Kazuo Kumagai, Zhe Yang, Youngmin Yang, Katsumi Shigemura, Hideto Matsuyama Tags: RESEARCH ARTICLE Source Type: research

Preparation, function, and safety evaluation of a novel degradable dermal filler, the cross ‐linked poly‐γ‐glutamic acid hydrogel particles
AbstractPoly- γ-glutamic acid (PGA) is a naturally degradable hydrophilic linear microbial polymer with moisturizing, immunogenic, cross-linking, and hydrogel water absorption properties similar to hyaluronic acid, a biomaterial that is commonly used as a dermal filler. To explore the development feasibility of cross-linked PGA as a novel dermal filler, we studied the local skin response to PGA fillers and the effect of various cross-linking preparations on the average longevity of dermal injection. Injection site inflammation and the formation of collagen and elastin were also determined. PGA hydrogel par ticles prepared...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 18, 2023 Category: Materials Science Authors: Mian Chen, Lei Chen, Dandan Yuan, Linlin Niu, Jianting Hu, Xiaoyuan Zhang, Xiuhua Zhang, Yanyan Zhang, Xiangjun Zhang, Peixue Ling, Fei Liu, Daizhou Zhang Tags: RESEARCH ARTICLE Source Type: research

Silicon nanowire array overcomes chemotherapeutic resistance by inducing the differentiation of breast cancer stem cells
In this study, we report the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lose the stemness properties and thus become sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs. Therefore, this work suggests a potential approach for overcoming chemotherapeutic resistance. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 17, 2023 Category: Materials Science Authors: Xiaotong Wang, Sisi Liu, Wei Zhang, Haotong Peng, Miao Zhang, Yaping Li, Qi Guo, Wenjing Wang, Na Huang, LiYan Liu, Dandan Liu Tags: RESEARCH ARTICLE Source Type: research

Effect of nano ‐ceramic coating on surface property and microbial adhesion to poly(methyl methacrylate)
AbstractTo improve surface properties of poly(methyl methacrylate) (PMMA) using nano-ceramic coatings and assess microbial adherence after long-term use of a chemical cleanser. Thirty-six PMMA samples were fabricated, polished and coated with a nano-thin TiO2 or mixed TiO2/ZrO2, with uncoated samples as controls. Six samples in each group (n = 12) were soaked in Polident denture cleaner 180 times for 30 min, while six were soaked in deionized water. Surface roughness of PMMA before and after being soaked in Polident was assessed. All samples were subsequently exposed toCandida albicans for 6  h and the adherent cells ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 16, 2023 Category: Materials Science Authors: Bin Yang, Shari Ginsburg, Wei Li, Marina Moscardini Vilela, Mina Shahmohammadi, Christos G. Takoudis, Christine D. Wu Tags: RESEARCH ARTICLE Source Type: research

Fabrication of hydroxyapatite ‐based nano‐gold and nano‐silver‐doped bioceramic bone grafts: Enhanced mechanostructure, cell viability, and nuclear abnormality properties
In this study, nano-gold (nAu) and nano-silver (nAg) were doped at the molar ratios of Molar5 –Molar30 to the Hydroxyapatite (HAp)-based bioceramic bone graft synthesized by the sol–gel method. The effects of nAu and nAg on structural, mechanical, cell viability, and nuclear abnormality of the synthesized bioceramic grafts were evaluated. The chemical and morphological properties of the bone grafts after production were examined through XRD and SEM–EDX analyses and mechanical tests. To determine the biocompatibility of the bone grafts, cell viability tests were performed using human fibroblast cells. In the cytotoxic...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 10, 2023 Category: Materials Science Authors: M. Demirel, N. Aslan, B. Aksakal, M. E. Arslan Tags: RESEARCH ARTICLE Source Type: research

Alkaline earth metals for osteogenic scaffolds: From mechanisms to applications
AbstractRegeneration of bone defects is a significant challenge today. As alternative approaches to the autologous bone, scaffold materials have remarkable features in treating bone defects; however, the various properties of current scaffold materials still fall short of expectations. Due to the osteogenic capability of alkaline earth metals, their application in scaffold materials has become an effective approach to improving their properties. Furthermore, numerous studies have shown that combining alkaline earth metals leads to better osteogenic properties than applying them alone. In this review, the physicochemical an...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 9, 2023 Category: Materials Science Authors: Yihang Weng, Yujia Jian, Wenlong Huang, Zhuojun Xie, Ying Zhou, Xibo Pei Tags: REVIEW ARTICLE Source Type: research

Clinical application of 3D ‐printed biodegradable lumbar interbody cage (polycaprolactone/β‐tricalcium phosphate) for posterior lumbar interbody fusion
AbstractA novel 3D-printed biodegradable cage composed of polycaprolactone (PCL) and beta-tricalcium phosphate ( β-TCP) in a mass ratio of 50:50, with stable resorption patterns and mechanical strength has been developed for lumbar interbody fusion. This is a prospective cohort study to evaluate the short- and mid-term safety and efficacy of this biodegradable cage in posterior lumbar interbody fusion (PLIF) surgery. This was a prospective single-arm pilot clinical trial in 22 patients with a follow-up time of 1, 3, 6, and 12 months, postoperatively. Clinical outcomes were assessed using the Japanese Orthopedic Associat...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 8, 2023 Category: Materials Science Authors: Yichao Liu, Hao Wu, Shusen Bao, Hai Huang, Zhen Tang, Hui Dong, Jiaqi Liu, Shengxiu Chen, Ning Wang, Zhigang Wu, Zhiyong Zhang, Lei Shi, Xiaokang Li, Zheng Guo Tags: RESEARCH ARTICLE Source Type: research

Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications
AbstractNiFeMo alloy nanoparticles were synthesized by co-precipitation in the presence of organic additives. Nanoparticles thermal evolution shows that there is a significant increase in the average size (from 28 to 60  nm), consolidating a crystalline structure of the same type as the Ni3Fe phase but with lattice parameter a  = 0.362 nm. Measurements of magnetic properties follow this morphological and structural evolution increasing saturation magnetization (Ms) by 578% and reducing remanence magnetization (Mr) by 29%. Cell viability assays on as-synthesized revealed that nanoparticles (NPs) are not cytotoxic up t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 8, 2023 Category: Materials Science Authors: Fabio Muchenski, Jenifer Pendiuk Gon çalves, Yasmin Carla Ribeiro, Célia Regina Cavichiolo Franco, Carolina Camargo Oliveira, Bruna Hilzendeger Marcon, Anny Robert, Lia Carolina Soares Medeiros, Ronei Cardoso Oliveira, Adilson Jesus Aparecido O Tags: RESEARCH ARTICLE Source Type: research

Type H blood vessels in coupling angiogenesis ‐osteogenesis and its application in bone tissue engineering
This review provides an overview unmasking important characteristics of type H blood vessels, the specific role of type H vessels in coupling angiogenesis and osteogenesis. This review also summarizes the application of tissue engineering in the regulating of type H blood vessels to treat multiple bone diseases through various signal pathways. AbstractOne specific capillary subtype, termed type H vessel, has been found with unique functional characteristics in coupling angiogenesis with osteogenesis. Researchers have fabricated a variety of tissue engineering scaffolds to enhance bone healing and regeneration through the a...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 7, 2023 Category: Materials Science Authors: Zhengyi Xu, Anjali P. Kusumbe, He Cai, Qianbing Wan, Junyu Chen Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 4, 2023 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Pterostilbene loaded poly(vinyl alcohol) ‐gelatin cryogels as potential bioactive wound dressing material
In this study, polyvinyl alcohol-gelatin (PVA-Gel) based cryogel membranes loaded with pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene; PTS) (PVA-Gel/PTS) was synthesized as wound dressing materials. PVA-Gel and PVA-Gel/PTS were synthesized with the polymerization yields of 96%  ± 0.23% and 98% ± 0.18%, respectively, and characterized by swelling tests, Brunauer–Emmett–Teller (BET) and scanning electron microscopy (SEM) analysis. The swelling ratios were calculated as 98.6% ± 4.93% and 102% ± 5.1%, macroporosities were determined as 85% ± 2.13% and 88% ± 2.2%, for PVA-Gel and PVA-Gel/...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 3, 2023 Category: Materials Science Authors: İpek Canatar, Okan Zenger, Sibel Özdaş, Gözde Baydemir Peşint Tags: RESEARCH ARTICLE Source Type: research

Toxicity evaluation of choline ionic liquid ‐based nanocarriers of pharmaceutical agents for lung treatment
AbstractIn vitro cytotoxicity evaluation of linear copolymer (LC) containing choline ionic liquid units and its conjugates with an antibacterial drug in anionic form, that is,p-aminosalicylate (LC_PAS), clavulanate (LC_CLV), or piperacillin (LC_PIP) was carried out. These systems were tested against normal: human bronchial epithelial cells (BEAS-2B), and cancers: adenocarcinoma human alveolar basal epithelial cells (A549), and human non-small cell lung carcinoma cell line (H1299). Cells viability, after linear copolymer LC and their conjugates addition for 72  h, was measured at concentration range of 3.125–100 μg/m...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 3, 2023 Category: Materials Science Authors: Katarzyna Niesyto, Magdalena Skonieczna, Ma łgorzata Adamiec‐Organiściok, Dorota Neugebauer Tags: RESEARCH ARTICLE Source Type: research