Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preparation and characterization of a self ‐crosslinking sodium alginate‐bioactive glass sponge
AbstractIn this research, bioactive glass particles prepared by the reactive flash nanoprecipitation method (RFNP-BG particles) are used to crosslink sodium alginate to prepare biological sponges (SA-BG sponges) by freeze-drying. An experiment for the cross-linking mechanism confirms that the continuous release of Ca2+ from RFNP-BG is promoted by the crosslinking reaction and in turn leads to the gelation process of SA. Bioactive glass particles not only provide Ca2+ for the crosslinking of sodium alginate, but also enhance the mechanical properties of the SA-BG sponges. The results show that the elastic modulus of the SA-...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 8, 2022 Category: Materials Science Authors: Wensheng Gong, Lingling Liu, Liping Luo, Lijun Ji Tags: RESEARCH ARTICLE Source Type: research

Injectable extracellular matrix hydrogels contribute to native cell infiltration in a rat partial nephrectomy model
This study is the first to show that dECM hydrogels can be applied to the kidney, one of the most complex structural organs and that they can function as a scaffold to induce angiogenesis and infiltration of organ-specific renal tubular constituent cells, providing fundamental insights for further application of dECM hydrogels. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 8, 2022 Category: Materials Science Authors: Hiroko Kushige, Yuki Amano, Hiroshi Yagi, Toshinori Morisaku, Hideaki Kojima, Akiko Satou, Ken ‐ichi Hamada, Yuko Kitagawa Tags: RESEARCH ARTICLE Source Type: research

Comparison of the enhanced attachment and proliferation of the human mesenchymal stem cells on the biomimetic nanopatterned surfaces of zein, silk fibroin, and gelatin
AbstractNatural proteins have been reported to positively affect the attachment and proliferation of cells. For the first time, zein, a plant protein, was utilized to make patterned surface mimicking the extracellular matrix to assist the attachment and proliferation of stem cells. Zein would promote the attachment and proliferation of the stem cells more than 10 times of that of gelatin and silk fibroin, respectively, which are popular protein selections for the formation of the biomaterial scaffolds. The more the surface was covered by zein, the more the stem cell grown. It was revealed that the stem cells would grow and...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 4, 2022 Category: Materials Science Authors: Xueying Huang, Jie Zeng, Yi Wang Tags: RESEARCH ARTICLE Source Type: research

3D ‐printed hydroxyapatite scaffolds for bone tissue engineering: A systematic review in experimental animal studies
In conclusion, 3D-printed HA scaffolds are excellent candidates as bone grafts due to their bioactivity and good bone interaction. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 30, 2022 Category: Materials Science Authors: Ingrid Regina Avanzi, Julia Risso Parisi, Amanda Souza, Matheus Almeida Cruz, Cintia Cristina Santi Martignago, Daniel Araki Ribeiro, Anna Rafaela Cavalcante Braga, Ana Claudia Renno Tags: REVIEW ARTICLE Source Type: research

Laddec ® versus Bio‐Oss®: The effect on the healing of critical‐sized defect – Calvaria rabbit model
AbstractThe aim of this study was to evaluate thein vivo performance of two different deproteinized bovine bone (DBB) grafting materials: DBBB (Bio-Oss ®) and DBBL (Laddec®), for the regeneration of critically sized (8 mm) defects in rabbit's calvaria. Three round-shaped defects were surgically created in the calvaria of 13 New Zealand White rabbits proximal to the coronal suture in the parietal bone. Two of the defects were filled with one of the grafting materials while a third was left empty to serve as a negative control. Bone regeneration properties were evaluated at 4- and 8-weeks after implantation by means of h...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 20, 2022 Category: Materials Science Authors: Luiz Fernando Gil, Vasudev Vivekanand Nayak, Ernesto B. Benalc ázar Jalkh, Nick Tovar, Kai‐Jen Chiu, Jaime Campos Salas, Charles Marin, Michelle Bowers, Gileade Freitas, Dejolie Christelle Mbe Fokam, Paulo G. Coelho, Lukasz Witek Tags: RESEARCH ARTICLE Source Type: research

Comparison of decellularization protocols for cultured cell ‐derived extracellular matrix—Effects on decellularization efficacy, extracellular matrix retention, and cell functions
AbstractThe in vitro reconstruction of the extracellular matrix (ECM) is required in tissue engineering and regenerative medicine because the ECM can regulate cell functions in vivo. For ECM reconstruction, a decellularization technique is used. ECM reconstructed by decellularization (dECM) is prepared from tissues/organs and cultured cells. Although decellularization methods have been optimized for tissue-/organ-derived dECM, the methods for cultured cell-derived dECM have not yet been optimized. Here, two physical (osmotic shocks) and five chemical decellularization methods are compared. The decellularization efficacies ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 20, 2022 Category: Materials Science Authors: Takashi Hoshiba, Shunji Yunoki Tags: RESEARCH ARTICLE Source Type: research

Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis
The objective was to synthesize and characterize fine polycaprolactone (PCL) fibers associated with a new 58S bioglass obtained by the precipitated sol –gel route, produced by the electrospinning process in order to incorporate therapeutic ions (Mg and Li). In PCL/acetone solutions were added 7% pure bioglass, bioglass doped with Mg(NO3)2 and Li2CO3 and were subjected to electrospinning process. The fibers obtained were characterized morphologically, chemically and biologically. The results showed the presence of fine fibers at the nanometric scale and with diameters ranging from 0.67 to 1.92  μm among groups. Groups ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 19, 2022 Category: Materials Science Authors: Elisa Camargo Kukulka, Joyce Rodrigues Souza, Juliani Carolini Ribeiro Ara újo, Luana Marotta Reis Vasconcellos, Tiago Moreira Bastos Campos, Gilmar Patricínio Thim, Alexandre Luiz Souto Borges Tags: RESEARCH ARTICLE Source Type: research

Influence of the calcium orthophosphate:glass ratio and calcium orthophosphate functionalization on the degree of conversion and mechanical properties of resin ‐based composites
AbstractThe study verified the influence of calcium orthophosphate (CaP):glass ratio on the degree of conversion and mechanical properties of resin-based composites containing either TEGDMA-functionalized dicalcium phosphate anhydrous (DCPA) or non-functionalized DCPA particles. The null hypotheses were that the evaluated variables are not affected by (1) CaP:glass ratio or (2) DCPA functionalization. DCPA particles were synthesized and half of them were functionalized with TEGDMA. Particle characterization included x-ray diffraction, elemental analysis, laser scattering, helium picnometry and scanning electron microscopy....
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 19, 2022 Category: Materials Science Authors: Amanda Lopes Campos, Bruna Marin Fronza, Marcela Charantola Rodrigues, Marina Damasceno e Souza Chiari, Roberto Ruggiero Braga Tags: RESEARCH ARTICLE Source Type: research

Comparison between different fracture toughness techniques in zirconia dental ceramics
AbstractVickers indentation (IF) and single-edge-V-notched beam (SEVNB), to measure the fracture toughness (KIC) of zirconia-based dental ceramics and mathematical models were proposed to establish a correlation between both. Zirconia (ZrO2) stabilized with 3  mol. % of Y2O3 (3Y-TZP) and 5  mol% of Y2O3 (5Y-PSZ) were compacted (n = 42) and sintered for 2 h at different temperatures (1475°C, 1500°C, 1550°C, or 1600°C). After sintering, they were characterized by relative density using the ASTM C373-88 standard, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The average grain size was measured accor...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 18, 2022 Category: Materials Science Authors: Manuel Fellipe Rodrigues Pais Alves, Claudinei Santos, Carlos Nelson Elias, Jos é Eduardo Vasconcellos Amarante, Sebastião Ribeiro Tags: RESEARCH ARTICLE Source Type: research

The improvement of periodontal tissue regeneration using a 3D ‐printed carbon nanotube/chitosan/sodium alginate composite scaffold
In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 16, 2022 Category: Materials Science Authors: Lai Suo, Hongshan Wu, Puyu Wang, Zhijun Xue, Jing Gao, Jing Shen Tags: RESEARCH ARTICLE Source Type: research

Polycrystalline particulates synthesized on zirconia for enhanced bioactivity: An in vitro study
AbstractZirconia is a promising material for dental implant with its excellent biocompatibility, good mechanical properties, and esthetic effect similar to natural teeth. To improve the bioactivity and osteogenic properties of zirconia, pre-sintered zirconia discs were divided into C, T3, T5, and T7 group. Group C was as control. T3, T5, and T7 groups were soaked in hydrofluoric acid (HF) for 30, 50, and 70  s, respectively. Then, they were placed into CaCl2 solution and heated in NaOH solution. After sintering, the samples were characterized by scanning electron microscopy, energy dispersive spectrometry, and X-ray diff...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 16, 2022 Category: Materials Science Authors: Shuang Tang, Ning Ding, Zutai Zhang Tags: RESEARCH ARTICLE Source Type: research

The significance of nanofiber polyglycolic acid for promoting tissue repair in a rat subcutaneous implantation model
AbstractAmong various biomaterials, we focused on nanofiber-based polyglycolic acid (PGA) fabric and examined the dynamics of cells that migrate within the non-woven fabric after implantation. The efficacy of nano-PGA as a tissue reinforcement in the process of subcutaneous tissue repair was immunohistochemically investigated. Two types of clinically available PGA non-woven sheet (nano-PGA: fiber diameter  = 2.0 μm, conventional PGA: fiber diameter = 14.2 μm) were used and subcutaneously implanted in rats. Samples were collected 3 days, and 1, 2, 3, and 4 weeks after the implantation to perform histological and...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 16, 2022 Category: Materials Science Authors: Yu Sueyoshi, Atsuko Niwa, Yuki Nishikawa, Noritaka Isogai Tags: RESEARCH ARTICLE Source Type: research

Development of a novel low ‐background noise blood loop model for testing blood‐contacting biomaterials and medical devices in fresh human blood
AbstractA novel low volume blood loop model (Ension Triad System [ETS]) incorporating pulsatile flow and a proprietary low-activation blood-contacting surface (Ension bioactive surface [EBS]) enabling high signal-to-noise performance is described. The ETS system incorporates a test chamber that allows direct comparison of material samples or finished medical devices such as catheters with varying compositions and/or surface treatments. ETS performance is presented from two independent organizations (Medtronic and MLM Labs) and includes results for hemolysis (pfHgb), platelet count, platelet activation ( βTG), coagulation ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 14, 2022 Category: Materials Science Authors: Patrick Cahalan, Michael Hegy, Linda Cahalan, Ben Curry, Samantha Ubl, Hannah Jeffers, Michael F. Wolf Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 13, 2022 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Complete proteomic profiling of regenerative bio ‐scaffolds with a two‐step trypsinization method
In this study, we have applied proteomic profiling with a two-step sequential trypsinization method, and identified and quantified 300 –400 constituent proteins in three commercially available regenerative bio-scaffolds (BioDesign Surgisis, ReGen tissue matrix, and ThormalGEN mesh). These proteins were classified into four categories and 14 subcategories based on their mainly biological function. The main components of regenerati ve bio-scaffolds were highly abundant ECM structural proteins, and the minor parts of bio-scaffolds were lowly abundant, less cross-linked, functionally more diversified proteins, especially ext...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 13, 2022 Category: Materials Science Authors: Huidan Wang, Wendell Q. Sun, Jian Wang Tags: RESEARCH ARTICLE Source Type: research