CD4+ T cells related to disease severity in elderly and frailty community ‐acquired pneumonia patients: A retrospective cohort study
ConclusionsCD4+ T cells decreased in elderly and frailty SCAP patients, and CD4+ T cells combined with PCT were relatively accurate in the prediction of elderly and frailty SCAP. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 30, 2023 Category: Allergy & Immunology Authors: Jue Wang,
Lu Pei,
Ting Zhao,
Xiaoli Liu,
Quanrong Wang,
Shiyu Zhang,
Jubo Li,
Hongwei Wu,
Dongsheng Niu Tags: ORIGINAL ARTICLE Source Type: research
The effect of TEMPOL pretreatment on postoperative cognitive function, inflammatory response, and oxidative stress in aged rats under sevoflurane anesthesia
ConclusionsTEMPOL pretreatment attenuated postoperative cognitive impairment induced by sevoflurane anesthesia in aged rats. This may be attributed to the downregulation of NR2B-CREB-BDNF pathway, reducing the inflammatory response and oxidative stress damage in hippocampal tissue. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Tianpin Liu,
Tianzi Chen,
Jianhua Gong,
Changchang You,
Bo Zhang,
Caiyun Luo,
Zhigui Liu,
Chun Chen Tags: ORIGINAL ARTICLE Source Type: research
Insights on Covid ‐19 with superimposed pulmonary histoplasmosis: The possible nexus
Pulmonary histoplasmosis may occur in Covid-19 patients; therefore, immune dysregulation chiefly lymphopenia in Covid-19 may increase the risk for the progress of pulmonary histoplasmosis. As well, the activation of inflammatory signaling pathways during H. Capsulatum infection may increase the severity of Covid-19 and vice versa. AbstractA novel coronavirus (CoV) known as severe acute respiratory syndrome CoV type 2 is the causative agent for the development of CoV disease 2019 (Covid-19). Covid-19 may increase the risk of developing pulmonary histoplasmosis due to immune dysregulation. In addition, Covid-19 may enhance t...
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Yahya A. Almutawif,
Hayder M. Al ‐kuraishy,
Ali I. Al‐Gareeb,
Athanasios Alexiou,
Marios Papadakis,
Hamza M. A. Eid,
Hebatallah M. Saad,
Gaber El‐Saber Batiha Tags: REVIEW ARTICLE Source Type: research
Ascaridia galli infection in chicken: Pathobiology and immunological orchestra
Ascaridia galli is the most common helminth in chickens. It is more common in young chickens. The helminth induces huge economic losses in poultry. AbstractBackgroundAscaridia galli is the largest gut-dwelling helminth of chickens, which confers adverse effects on meat and egg production; thus, on the animal protein supply and the economy. Both adult and immature parasites affect gut health, but larval stages play a major role in pathology.AimsHere, we present immunology and pathology ofA. galli in chickens.Materials and MethodsLiteratures were surveyed through online platforms such as PubMed, Google Scholar and Researchga...
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Nusrat Nowrin Shohana,
Sharmin Aqter Rony,
Md. Haydar Ali,
Md. Shahadat Hossain,
Sharmin Shahid Labony,
Anita Rani Dey,
Thahsin Farjana,
Mohammad Zahangir Alam,
Md. Abdul Alim,
Anisuzzaman Tags: REVIEW ARTICLE Source Type: research
Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID ‐19 patients
ConclusionsAmong hematological indices, NLR and more precisely PLR are cost-effective and simply calculable markers that can assist physicians in determining whether or not COVID-19 patients with clinically probable PTE require CT angiography and the higher neutrophil count can be employed as an indicator of PTE severity in COVID-19 patients. Further large multicenter and prospective studies are warranted to corroborate these observations. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Hanieh Radkhah,
Ensieh Sadat Mansouri,
Shiva Rahimipour Anaraki,
Milad Gholizadeh Mesgarha,
Ali Sheikhy,
Mohamad Mehdi Khadembashiri,
Mohamad Amin Khadembashiri,
Mohamad Eslami,
Tara Mahmoodi,
Behnaz Inanloo,
Arash Pour Mohammad Tags: ORIGINAL ARTICLE Source Type: research
Knowledge and attitudes of gout patients and their perspectives about diagnosis and management: A cross ‐sectional study in Saudi Arabia
ConclusionThe patients diagnosed with gout in Saudi Arabia exhibited a satisfactory level of information, attitude, and perspectives regarding their condition. The participants expressed a significant degree of satisfaction with the impact of gout management on their occupational performance, work-life balance, and professional plans. Additional research is necessary to ascertain the risk factors associated with gout and provide suitable preventative interventions. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Abdulrahman A. M. Khormi,
Abdulaziz A. Basalem,
Alhaytham M. Z. Al Muaddi,
Abdulaziz M. Alaskar,
Rakan A. S. Algahtani,
Abdulsalam S. Alharbi,
Tariq D. M. Alanazi,
Nawaf A. Alqahtani,
Abdulrahman A. S. Altamimi Tags: ORIGINAL ARTICLE Source Type: research
Activation of Toll ‐like receptor 4 by thyroid hormone triggers abnormal B‐cell activation
ConclusionThe present study indicated that high levels of T3 can induce abnormal differentiation and activation of B cells by promoting TLR4 overexpression and provide novel insights into the roles of THs in the pathogenesis of GD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Jie Wang,
Guo ‐Qing Li,
Shu Liu,
Jing‐Jing Miao,
Qi Sun,
Wen‐Sha Gu,
Xiao‐Ming Mao Tags: ORIGINAL ARTICLE Source Type: research
The clinical and immunological characteristics of COVID ‐19 patients with delayed SARS‐CoV‐2 virus clearance
ConclusionCDVC patients still have SARS-CoV-2 and these cases manifest with severe clinical symptoms due to persistent inflammation. Augmentation of the frequency of circulating Treg, severe lymphopenia, and functional exhaustion of T cells might lead to inefficient clearance of SARS-CoV-2. Therefore, enhancing lymphocyte counts and reversing T-cell exhaustion might be key methods to boost immune responses and eliminate SARS-CoV-2 in CDVC patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Jinsong Wang,
Debao Li,
Bo Tang,
Xuemin Sun,
Wenjiong Shi,
Hao Li,
Zhenhua Zhang,
Yuzhang Wu,
Yi Zhang,
Qinghua Qiao Tags: ORIGINAL ARTICLE Source Type: research
ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress
ConclusionsATF3 downregulation reduced SPHK1 expression to attenuate cardiomyocyte injury in MI. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 29, 2023 Category: Allergy & Immunology Authors: Huiling Chen,
Suxin Luo,
Huamei Chen,
Cong Zhang Tags: ORIGINAL ARTICLE Source Type: research
ScRNA ‐seq revealed disruption in CD8+ NKG2A+ natural killer T cells in patients after liver transplantation and immunosuppressive therapy
ConclusionsWe comprehensively analyzed single-cell RNA sequencing data from a normal individual and patients who underwent LT and elucidated the mechanism underlying the development of immune tolerance in LT. CD8+ NKT cells specifically expressing KLRC1 play a crucial role in LT, and dynamic monitoring of these cells may provide novel avenues for the diagnosis and treatment of LT-related immune rejection. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 28, 2023 Category: Allergy & Immunology Authors: Yuan Fang,
CongWen Bian,
ZhiTao Li,
Li Jin,
ChuHong Chen,
YingLei Miao,
HanFei Huang,
Zhong Zeng Tags: ORIGINAL ARTICLE Source Type: research
Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein ‐α and human livin α exert an antitumor effect against Lewis lung carcinoma in mice
ConclusionInjection with rAd-FAP/hlivin α-transduced DCs promotes immune-enhanced tumor microenvironment by decreasing CAFs and suppresses tumor growth in LLC mouse models. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 27, 2023 Category: Allergy & Immunology Authors: Zaiting Ye,
Jiongwei Pan,
Zhangyong Yin,
Shuanghu Wang,
Yuling Li,
Xiaoping Cai,
Hao Zheng,
Zhuo Cao Tags: ORIGINAL ARTICLE Source Type: research
Development of heart failure with preserved ejection fraction is independent of eosinophils in a preclinical model
This is the first report to evaluate the role of eosinophils in heart failure with preserved ejection fraction (HFpEF), where a novel preclinical model of HFpEF and eosinophil-deficient mice was utilized. Results indicated that the development of HFpEF is independent of eosinophils, providing new insights into the roles of eosinophils in cardiovascular diseases. AbstractThe increasing burden of heart failure with preserved ejection fraction (HFpEF) has become a global health problem. HFpEF is characterized by systematic inflammation, cardiac metabolic remodeling, and fibrosis. Eosinophils act as an essential but generally ...
Source: Immunity, Inflammation and Disease - September 27, 2023 Category: Allergy & Immunology Authors: Qi Pan,
Cheng Chen,
Zhaoting Gong,
Guihao Chen,
Yuejin Yang Tags: SHORT REPORT Source Type: research
Food ‐specific IgA levels in esophageal biopsies are not sufficiently high to predict food triggers in eosinophilic esophagitis
ConclusionsFood-specific IgA in esophageal biopsies was not associated with previously identified food triggers in this cohort. Future studies comparing food-specific IgA in esophageal brushings, mucous scrapings, and biopsies from patients with known triggers will be critical to determining whether food-specific IgA may serve as a biomarker for identification of EoE triggers. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 27, 2023 Category: Allergy & Immunology Authors: Lior Abramson,
Johanna M. Smeekens,
Michael D. Kulis,
Evan S. Dellon Tags: SHORT REPORT Source Type: research
Death receptor 3 is involved in preeclampsia through regulating placental trophoblast cell physiology by inactivating the PI3K/AKT pathway
ConclusionDR3 was involved in PE through regulating placental trophoblast cell physiology via PI3K/AKT pathway, which might be a promising therapeutic target for PE therapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 27, 2023 Category: Allergy & Immunology Authors: Cheng Yin,
Jiahui Wang,
Yu Zhang,
Xinping Zhang,
Wei Zhao,
Yanxiang Shen,
Shi Liu,
Su Liu Tags: ORIGINAL ARTICLE Source Type: research
Plumbagin alleviates obesity ‐related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway
ConclusionThe study suggested that HFD exacerbated inflammation and oxidative stress, while PLB probably alleviated inflammation and oxidative stress and activated AMPK pathway to attenuate obesity-associated asthma. Thus, PLB likely had the potential to treat obesity-related asthma. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 27, 2023 Category: Allergy & Immunology Authors: Lijie Zhang,
Dongxue Liang,
Linlin Liu,
Lihua Liu Tags: ORIGINAL ARTICLE Source Type: research
