Metformin inhibits high glucose ‐induced apoptosis of renal podocyte through regulating miR‐34a/SIRT1 axis
ConclusionThis study proposes a promising approach to interpret the mechanisms of action of the MFN-miR-34a axis involved in DN. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Xudong Zhuang,
Zhuye Sun,
Huasheng Du,
Tianhui Zhou,
Jing Zou,
Wei Fu Tags: ORIGINAL ARTICLE Source Type: research
Social determinants of health disparities in Staten Island compared with Manhattan, Queens, Brooklyn, and the Bronx: Contribution to COVID ‐19 outcomes
ConclusionDifferences in COVID-19 infection, hospitalization, and death rates exist between the five boroughs and between the 12 zip codes within Staten Island. These differences in COVID-19 outcomes can be attributed to different SDH. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Masha Kolesnikova,
Haram Abdelmajid,
Stephan Kohlhoff,
Tamar A. Smith ‐Norowitz Tags: ORIGINAL ARTICLE Source Type: research
Eliciting and stop dose during oral food challenges for peanut and common tree nuts in different age groups
ConclusionsTwo third of children under 6 years of age successfully consumed all the provided doses during OFCs with a negative outcome. The eliciting dose for objective symptoms was not associated with age, and in a substantial number of OFCs with positive outcome, symptoms occurred after eating the final dose. These findings suggest that in case of an uneventful OFC, the outcome should be drawn only after a cumulative dose of 4.4 g has been consumed to avoid the risk of a potential false negative outcome. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Wouter W. de Weger,
Diede Jansen,
Lidy van Lente,
Gerbrich N. van der Meulen,
Arvid W. A. Kamps Tags: ORIGINAL ARTICLE Source Type: research
The functional role of CST1 and CCL26 in asthma development
ConclusionOur results indicate that an overexpression ofCST1 andCCL26 cause a downregulation of interferon related genes and inflammatory proteins. It might cause a higher disease susceptibility, mainly for allergic asthma, asCCL26 is an agonist for CCR-3-carrying cells, such as eosinophils and Th2 lymphocytes, mostly active in allergic asthma. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Angela Hoyer,
Sandip Chakraborty,
Ingrid Lilienthal,
Jon R. Konradsen,
Shintaro Katayama,
Cilla S öderhäll Tags: ORIGINAL ARTICLE Source Type: research
Clinical performance of AMA ‐M2, anti‐gp210 and anti‐sp100 antibody levels in primary biliary cholangitis: When detected by multiplex bead‐based flow fluorescent immunoassay
ConclusionThe detection of AMA-M2, anti-gp210 and anti-sp100 antibody levels by MBFFI showed good performance in the diagnosis of PBC. Serum anti-gp210 antibody level is related to cirrhosis, poor liver function and severe cholestasis in PBC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Zhan Wang,
Yongxin Li,
Lisheng Ren,
Yujie Li,
Tiantian Xu,
Wenshuai Li,
Weize Gao,
Guirong Sun,
Mingjun Liu Tags: ORIGINAL ARTICLE Source Type: research
Single ChAdOx1 nCoV ‐19 dose elicits stronger immune response in previously infected individuals than in SARS‐CoV2 naive persons
ConclusionsPrevious COVID-19 infection is associated with higher levels of SARS-CoV-2 antibodies following ChAdOx1 (AstraZeneca) vaccination. Our finding supports the notion that a single dose of ChAdOx1 nCoV-19 administered post-SARS-CoV-2 infection serves as an effective immune booster. This provides a possible rationale for a single-dose vaccine regimen for previously infected individuals. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Fawzi Ebrahim,
Asma Alboueishi,
Inas M. Alhudiri,
Salah Al Tabal,
Yosra Lamami,
Samira Al Dwigen,
Sondos Ashleb,
Noha Ejenfawi,
Mohamed B. Milad,
Hayat Rhoumah,
Salah Edin El Meshri,
Adam Elzagheid Tags: ORIGINAL ARTICLE Source Type: research
High immunocompetence in chronic hepatitis patients with normal alanine transaminase levels and and negative hepatitis B e ‐antigen for the progression of liver fibrosis
ConclusionAge and Treg are independent risk factors for progressive liver fibrosis. The cutoff value of Treg > 6.81 indicates the need for timely antiviral treatment and can serve as an indicator for evaluating liver fibrosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 18, 2024 Category: Allergy & Immunology Authors: Bianqiao Cheng,
Dandan Wu,
Ming Zhang,
Shiming Chen,
Xunyuan Wu,
Jingjing Zhong,
Meimei Wu,
Miaomiao Huo Tags: ORIGINAL ARTICLE Source Type: research
The Lnc ‐ENST00000602558/IGF1 axis as a predictor of response to treatment with tripterygium glycosides in rheumatoid arthritis patients
ConclusionWe found that genes expressed in the Lnc-ENST00000602558/IGF1 axis may be useful for identifying RA patients who will not respond to TG treatment. Our findings provide a rationale for the individualized treatment of RA in clinical settings. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 17, 2024 Category: Allergy & Immunology Authors: Yang Gao,
Xiaoyue Wang,
Yanfeng Gao,
Jian Bai,
Yanpeng Zhao,
Renyi Wang,
Hanzhou Wang,
Guangzhao Zhu,
Xixi Wang,
Xiaochen Han,
Yanqiong Zhang,
Hailong Wang Tags: ORIGINAL ARTICLE Source Type: research
Presence of neutralizing SARS ‐CoV‐2 antibodies in asymptomatic population of N'Djamena, Chad
ConclusionOur findings indicated a high presence of NAbs against SARS-CoV-2 spike protein among asymptomatic individuals in N'Djamena. This could be one of the reasons for the low severity of Covid-19 observed in this area, given the key role of NAbs in blocking SARS-CoV-2 infection. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 16, 2024 Category: Allergy & Immunology Authors: Andrillene Laure Deutou Wondeu,
Mahamat Fayiz Abakar,
Federica Frasca,
Aleyo Zita Nodjikouambaye,
Fatima Abdelrazakh,
Nathan Naibei,
Guy Rodrigue Takoudjou Dzomo,
Djallaye Djimtoibaye,
Joseph Mad ‐Toingue,
Carolina Scagnolari,
Guido Antonelli, Tags: ORIGINAL ARTICLE Source Type: research
Immunosuppressive therapy and COVID ‐19 infection in patients with NMOSD
DiscussionImmunosuppressant-treated patients with NMOSD have a similar risk of COVID-19 infection as the general population, but the disease duration is shorter and the clinical symptoms are less severe. Among our NMOSD patients who received hUC-MSCs treatment, COVID-19 outcomes were favorable, with no increased risk of severe COVID-19. Prospective studies on immunotherapies are needed to help determine best treatment practices. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 16, 2024 Category: Allergy & Immunology Authors: Un Wai Choi,
Xiwen Ai,
Hongyan Li,
Yong Hao,
Xiaoying Yao,
Yangtai Guan Tags: SHORT REPORT Source Type: research
Association between glucocorticoid receptor beta and steroid resistance: A systematic review
ConclusionGR- β was associated with steroid-resistant diseases. It was overexpressed in steroid-resistant diseases and has the potential to be used as a biomarker for disorders involving steroid resistance. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 13, 2024 Category: Allergy & Immunology Authors: Md. Mojahidur Hasan,
Sehreen Tory Tags: REVIEW ARTICLE Source Type: research
The effect of COVID ‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis
ConclusionCOVID-19 infection can result in ovarian reserve injury by reducing the AMH level but getting vaccinated against COVID-19 has no impact on the AMH level. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 11, 2024 Category: Allergy & Immunology Authors: Marjan Ghaemi,
Sedigheh Hantoushzadeh,
Arman Shafiee,
Omid Kohandel Gargari,
Hanieh Fathi,
Nasim Eshraghi,
Jafar Razavi,
Gholam Reza Habibi,
Kyana Jafarabady Tags: REVIEW ARTICLE Source Type: research
Interaction between long noncoding RNA and microRNA in lung inflammatory diseases
ConclusionsNumerous lncRNAs and miRNAs have been found to partipicate in all stages of lung inflammatory diseases. While ncRNA-based therapies have been validated and developed, there remain challenges in developing more stable and effective drugs for clinical use. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 10, 2024 Category: Allergy & Immunology Authors: Jiaqi Li,
Shengyu Huang,
Liangliang Shi,
Guochang Chen,
Xiaoxiao Liu,
Mingzhuo Liu,
Guanghua Guo Tags: REVIEW ARTICLE Source Type: research
Association of polymorphism of IL ‐17A, IL‐17F, and IL‐6 with Toxoplasma gondii infection susceptibility in HIV/AIDS patients in Shiraz, southern Iran
ConclusionThe findings of this study revealed that there were significant differences in the serum levels of IL-6 and IL-17A, but not IL-17F, between the case and control groups in various genetic models. However, these polymorphisms did not show a significant relationship with toxoplasma infection in HIV-positive patients. This study represents the first investigation in Iran to explore the role of IL-6 and IL-17 polymorphisms in toxoplasma infection among HIV-positive patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 10, 2024 Category: Allergy & Immunology Authors: Maryam Nejabat,
Mohammadreza Heydari,
Mohammad Motamedifar,
Zohre Foroozanfar,
Saeid Amirizadeh Fard,
Ava Hashempour,
Nazani Nazari,
Esmaeil Rezaei,
Zahra Heydari Tags: ORIGINAL ARTICLE Source Type: research
An integrative model with HLA ‐DR, CD64, and PD‐1 for the diagnostic and prognostic evaluation of sepsis
ConclusionThese findings indicate that the combinations of HLA-DR, CD64, and PD-1 outperformed each of the single indicator in diagnosis and predicting prognosis of sepsis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 10, 2024 Category: Allergy & Immunology Authors: Guosheng Chen,
Huimin Chong,
Peng Zhang,
Dalin Wen,
Juan Du,
Chu Gao,
Shi Zeng,
Ling Zeng,
Jin Deng,
Kejun Zhang,
Anqiang Zhang Tags: ORIGINAL ARTICLE Source Type: research
