High CRP/PNI levels predict an unfavorable prognosis in severe fever with thrombocytopenia syndrome: A propensity score matching study
ConclusionThe CPR/PNI ratio exhibited a strong positive correlation with the SFTS disease type and could predict in-hospital mortality in the early stages of SFTS. The CPR/PNI ratio could substantially help clinicians facilitate the early identification of patients with high-risk SFTS and the timely initiation of intensive therapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 20, 2024 Category: Allergy & Immunology Authors: Chunxia Guo,
Huan Wang,
Xiaorong Wang,
Shan Tian Tags: ORIGINAL ARTICLE Source Type: research
PPM1G regulates hepatic ischemia/reperfusion injury through STING ‐mediated inflammatory pathways in macrophages
ConclusionPPM1G suppresses hepatic IRI and macrophage M1 phenotype by repressing STING-mediated inflammatory pathways. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 20, 2024 Category: Allergy & Immunology Authors: Dadi Peng,
Zuotian Huang,
Hang Yang,
Yunhai Luo,
Zhongjun Wu Tags: ORIGINAL ARTICLE Source Type: research
Resveratrol attenuates intestinal epithelial barrier dysfunction via Nrf2/HO ‐1 pathway in dextran sulfate sodium‐induced Caco‐2 cells
ConclusionOverall, our findings suggested that Res ameliorated DSS-induced IECs barrier dysfunction by activating Nrf2/HO-1 pathway, showcasing significant therapeutic potential in the early stages of colitis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 19, 2024 Category: Allergy & Immunology Authors: Xinya Yu,
Yazhi Wang,
Yunchun Xu,
Xiaoxi Li,
Junhua Zhang,
Yunpeng Su,
Le Guo Tags: ORIGINAL ARTICLE Source Type: research
The role of interleukin ‐22 in mammalian intestinal homeostasis: Friend and foe
In conclusion, it appears that whether IL-22 has a beneficial or harmful effect in the mammalian intestine largely depends on its regulation. This review aims to provide a comprehensive overview of the current literature and emphasizes that IL-22 signaling outcome depends on the timing and duration of IL-22 production, the presence of it regulators such as IL-22BP, and the specific location of the cytokine production in the gastrointestinal tract. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 17, 2024 Category: Allergy & Immunology Authors: Hedi ‐Britt Klotskova,
Evelien Kidess,
Adria L. Nadal,
Sylvia Brugman Tags: REVIEW ARTICLE Source Type: research
NR5A2 promotes malignancy progression and mediates the effect of cisplatin in cutaneous squamous cell carcinoma
ConclusionNR5A2 plays a crucial role in the progression of cSCC, and the Wnt/ β-catenin signaling pathway may be involved in the regulation of NR5A2-mediated cSCC. Knockdown of NR5A2 enhanced both the proliferation inhibiting and apoptosis promoting effects of cisplatin on cSCC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 16, 2024 Category: Allergy & Immunology Authors: Wang Ye,
Cao Ya ‐xuan,
Tang Shan‐shan,
Long Qiu,
Ma Ting,
Chen Shao‐jie,
Cao Yu Tags: ORIGINAL ARTICLE Source Type: research
Quercetin attenuates inflammation in LPS ‐induced lung epithelial cells via the Nrf2 signaling pathway
ConclusionIn conclusion, these results suggested that quercetin attenuates LPS-induced inflammation in A549 by activating the Nrf2 signaling pathway. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 15, 2024 Category: Allergy & Immunology Authors: Pengju Lv,
Pengli Han,
Yuanbo Cui,
Qiusheng Chen,
Wei Cao Tags: ORIGINAL ARTICLE Source Type: research
Galectin ‐9 alleviates acute graft‐versus‐host disease after haplo‐hematopoietic stem cell transplantation by regulating regulatory T cell/effector T cell imbalance
ConclusionGalectin-9 may ameliorate aGVHD after haplo-HSCT by modulating Treg/Teffs balance and regulating the PI3K/AKT/mTOR pathway. Targeting Galectin-9 may hold potential value for the treatment of aGVHD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Nannan Pang,
Shabaaiti Tudahong,
Yuejie Zhu,
Jiang He,
Chunxia Han,
Gang Chen,
Weiguo Wang,
Jing Wang,
Jianbing Ding Tags: ORIGINAL ARTICLE Source Type: research
Association between preoperative systemic immune inflammation index and postoperative sepsis in patients with intestinal obstruction: A retrospective observational cohort study
ConclusionsA preoperative SII ＞ 1792.19 was a risk factor for postoperative sepsis in patients undergoing intestinal obstruction surgery. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Jirong Yang,
Taojia Ran,
Xiaoyu Lin,
Jinyan Xu,
Shaoli Zhou,
Chaojin Chen,
Pinjie Huang Tags: ORIGINAL ARTICLE Source Type: research
Intestinal mRNA expression analysis of polarity ‐related genes identified the discriminatory ability of CRB3 as a diagnostic marker for celiac disease
ConclusionThe aim of the current study was to evaluate the changes in the mRNA expression levels ofSCRIB,PRKCZ,LKB1, andCRB3 genes in the small intestinal biopsy samples of CD patients in comparison to the healthy control subjects. Our data uncover the importance of polarity-related genes (especiallyCRB3) in CD pahtomechanism, that may facilitate the planning of the future studies looking for finding innovative diagnostic and therapeutic strategies for CD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Tannaz Taraz,
Nastaran Asri,
Ehsan Nazemalhosseini ‐Mojarad,
Flora Forouzesh,
Mostafa Rezaei‐Tavirani,
Mohammad Rostami‐Nejad Tags: ORIGINAL ARTICLE Source Type: research
Autophagy ‐related genes polymorphism in hepatitis B virus‐associated hepatocellular carcinoma: A systematic review
ConclusionThe current study highlights the importance of rs2241880 in ATG16L1 and rs77859116, rs510432, and rs548234 in ATG5 for HBV-induced HCC. Additionally, some mutations in ATG16L1 and ATG5 were important in risk of HBV infection. The study highlights the gap of knowledge in the field of ATG polymorphisms in HBV infection and HBV-induced HCC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Parastoo Yousefi,
Alireza Tabibzadeh,
Abdulhussain Kadhim Jawaziri,
Mohsen Mehrjoo,
Mandana Akhavan,
Leila Allahqoli,
Hamid Salehiniya Tags: REVIEW ARTICLE Source Type: research
Three cases of systemic lupus erythematosus presenting with ischemic stroke as the initial symptom: Case reports and literature review
ConclusionIn young patients, particularly females presenting with ischemic stroke and especially in cases accompanied by hematologic or multisystemic involvement, there should be heightened vigilance for SLE-induced ischemic stroke. Early diagnosis and treatment significantly enhance patients' quality of life and survival rates. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 9, 2024 Category: Allergy & Immunology Authors: Na Li,
Xiaoxia Liu,
Pengjia Wu,
Jun Liu,
Pengyu Chen,
Jiashun Zeng Tags: ORIGINAL ARTICLE Source Type: research
Distinct cross talk of IL ‐17 & TGF ‐β with the immature CD11c+TRAF6(−/−)‐null myeloid dendritic cell‐derived osteoclast precursor (mDDOCp) may engage signaling toward an alternative pathway of osteoclastogenesis for arthritic bone loss in vivo
ConclusionThese results confirm and substantiate the validity of TRAF6( −/−)-null chimeras to address the significance of immature mCD11c+TRAP+DC-like OCs/mDDOCp subset for an alternative pathway of arthritic bone loss in vivo. Such CD11c+mDCs/mDDOCp-associated osteoclastogenesis through the step-wise twist-in-turns osteo-immune cross talks are thereby theme highlighted to depict a summative re-visitation proposed. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 8, 2024 Category: Allergy & Immunology Authors: Yen Chun G. Liu,
Andy Yen ‐Tung Teng Tags: ORIGINAL ARTICLE Source Type: research
Impact of occupational hazards on neurological health status in Pakistan: Challenges and recommendations
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 8, 2024 Category: Allergy & Immunology Authors: Zoaib Habib Tharwani,
Yumna Salman,
Maryam Irshad,
Mariam Adnan Rizvi,
Muhammad Hasanain,
Abdullah Malikzai Tags: COMMENTARY Source Type: research
Genetic determinants of SARS ‐CoV‐2 and the clinical outcome of COVID‐19 in Southern Bangladesh
ConclusionOur study identifies some risk factors such as age comorbidities (diabetes, hypertension, and renal disease) that are associated with severe COVID-19, providing valuable insight regarding prioritizing vaccination for high-risk individuals and allocating health care and resources. The findings of this work outlined the knowledge and mutational basis of SARS-CoV-2 for the next treatment steps. Further studies are needed to confirm the effects of structural and functional proteins of SARS-CoV-2 in detail for monitoring the emergence of new variants in future. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 7, 2024 Category: Allergy & Immunology Authors: Md. Mahbub Hasan,
Chayan Kumar Saha,
H. M. Hamidullah Mehedi,
Kallyan Chakma,
Asma Salauddin,
Md. Shakhawat Hossain,
Farjana Sharmen,
S. M. Rafiqul Islam,
Afroza Akter Tanni,
Farhana Yasmin,
Al ‐Shahriar Akash,
Mohammad Enayet Hossain,
Mojnu Tags: ORIGINAL ARTICLE Source Type: research
The role of the CX3CL1/CX3CR1 axis as potential inflammatory biomarkers in subjects with periodontitis and rheumatoid arthritis: A systematic review
ConclusionVery few studies highlight the role of the CX3CL1/CX3CR1 axis in the pathogenesis of periodontitis; however, increased levels of these chemokines are observed in different biological samples (GCF, gingival tissue, saliva, and serum) from subjects with periodontitis and RA compared with their healthy controls. Future studies should focus on long-term follow-up of subjects and monitoring changes in cytokine levels before and after periodontal therapy to deduce an appropriate interval in health and disease conditions. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 6, 2024 Category: Allergy & Immunology Authors: Mario A. Alarc ón‐Sánchez,
Julieta S. Becerra‐Ruiz,
Celia Guerrero‐Velázquez,
Seyed A. Mosaddad,
Artak Heboyan Tags: REVIEW ARTICLE Source Type: research
