Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice
ConclusionOverall, this study demonstrated that sensitization with 50 μg of OVA resulted in the most significant AHR compared to other dosages. These findings may offer valuable insights for future research on mouse asthma modeling protocols. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 27, 2024 Category: Allergy & Immunology Authors: Yan ‐Jiao Chen,
Yu Yuan,
Lu Peng,
Xin‐Yi Dong,
Yu‐Dong Xu,
Yu Wang,
Yong‐Qing Yang Tags: ORIGINAL ARTICLE Source Type: research
Association between helminth infection and allergic disorders among children in Batu, Ethiopia
Conclusion and clinical relevanceThis study found a non-significant inverse association between helminths infection and atopy and allergic disorders, likely due to reduced statistical power, resulting in a lower prevalence of atopy and allergic conditions. A high powered longtitudinal study is necessary to explore the casuality and potential therapeutic benefits of helminths for allergic disorders. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 23, 2024 Category: Allergy & Immunology Authors: Sosina Walelign,
Mheret Tesfaye,
Geremew Tasew,
Kassu Desta,
Aster Tsegaye,
Bineyam Taye Tags: ORIGINAL ARTICLE Source Type: research
Investigating the association between the tissue expression of miRNA ‐101, JAK2/STAT3 with TNF‐α, IL‐6, IL‐1β, and IL‐10 cytokines in the ulcerative colitis patients
ConclusionThis study provides evidence of increased miRNA-101 expression in UC tissue, suggesting a potential correlation between miRNA-101 and IL-6 expression and their involvement in the JAK2-STAT3 pathway. The study confirms alterations in UC patients' pro-inflammatory cytokines and anti-inflammatory IL-10. However, further investigations are needed to understand the exact role of miRNA-101 in UC pathogenesis fully. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 22, 2024 Category: Allergy & Immunology Authors: Qazaleh Voshagh,
Amir Anoshiravani,
Amin Karimpour,
Golnaz Goodarzi,
Sadra Samavarchi Tehrani,
Ozra Tabatabaei ‐Malazy,
Ghodratollah Panahi Tags: ORIGINAL ARTICLE Source Type: research
Diagnostic value of neutrophil ‐to‐lymphocyte and platelet‐to‐lymphocyte ratio to predict recurrent pregnancy loss and abortion; a systematic review and meta‐analysis
ConclusionNLR was significantly higher among RPL patients compared to the control group, according to these data, NLR may be capable of being used in the diagnosis of RPL as an easy, cheap, and accessible modality. Further studies, which take these variables into account, will need to be undertaken to determine the diagnostic value of NLR and PLR in early pregnancy loss. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 21, 2024 Category: Allergy & Immunology Authors: Sedigheh Hantoushzadeh,
Omid Kohandel Gargar,
Kyana Jafarabady,
Mohammad Moein Rezaei,
Fatemeh Asadi,
Nasim Eshraghi,
Zahra Panahi,
Saeedeh Shirdel,
Masoumeh Mirzamoradi,
Marjan Ghaemi Tags: REVIEW ARTICLE Source Type: research
Effects of therapeutic hypercapnia on the expression and function of γδT cells in transplanted lungs in rats
ConclusionOur findings suggest that γδ T lymphocytes were directly involved in lung injury. In addition, therapeutic hypercapnia effectively reduced the expression of γδ T cells and IL-17, and this has the potential to become a treatment strategy for IRI and an intervention to improve lung function. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 20, 2024 Category: Allergy & Immunology Authors: Qing Xie,
Jia Lu,
XiaoGuang Cui Tags: ORIGINAL ARTICLE Source Type: research
COVID ‐19 in patients with Down syndrome: A systematic review
ConclusionMore studies are needed to better understand COVID-19 infections among persons with DS. In addition, the study was limited by a lack of statistical analyses and a specific comparison group. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 20, 2024 Category: Allergy & Immunology Authors: Praveen N. K. Pitchan Velammal,
Suryakumar Balasubramanian,
Fathima Shehnaz Ayoobkhan,
Gautham V. K. Mohan,
Pearl Aggarwal,
Ali A. Rabaan,
Syed A. Khan,
Farah Yasmin,
Thoyaja Koritala,
Salim R. Surani Tags: REVIEW ARTICLE Source Type: research
Pyroptosis and polarization of macrophages in septic acute lung injury induced by lipopolysaccharide in mice
ConclusionPyroptosis of alveolar macrophages in the context of ALI in mice infected with sepsis has been linked to the polarization of alveolar macrophages toward type M1. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 19, 2024 Category: Allergy & Immunology Authors: Sijiang Zhou,
Xia Yang,
Kanglin Mo,
Zong Ning Tags: REVIEW ARTICLE Source Type: research
Sodium butyrate activates the KATP channels to regulate the mechanism of Parkinson's disease microglia model inflammation
ConclusionNaB treatment alleviates the MPP+-induced inflammatory responses in microglia via activation of KATP channels. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 19, 2024 Category: Allergy & Immunology Authors: Ye Xu,
Laofu Wen,
Yunyi Tang,
Zhenqiang Zhao,
Miaojing Xu,
Tan Wang,
Zhibin Chen Tags: ORIGINAL ARTICLE Source Type: research
Obesity correlates with the immunosuppressive ILC2s ‐MDSCs axis in advanced breast cancer
ConclusionConclusively, obesity may enhance the immunosuppressive effect of the ILC2-MDSC axis in advanced breast cancer. IL-5 may play a vital role in the ILC2-MDSC axis and obesity in TNBC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 19, 2024 Category: Allergy & Immunology Authors: Wei Liu,
Bingyu Li,
Dan Liu,
Bing Zhao,
Gang Sun,
Jianbing Ding Tags: ORIGINAL ARTICLE Source Type: research
Fortunellin ameliorates LPS ‐induced acute lung injury, inflammation, and collagen deposition by restraining the TLR4/NF‐κB/NLRP3 pathway
ConclusionFortunellin attenuated LPS-stimulated ALI through repressing the TLR4/NF- κB/NLRP3 pathway. Fortunellin may be a valuable drug for ALI therapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 19, 2024 Category: Allergy & Immunology Authors: Danjuan Liu,
Rongjie Guo,
Bingbing Shi,
Min Chen,
Shuoyun Weng,
Junting Weng Tags: ORIGINAL ARTICLE Source Type: research
Undaria pinnatifida ameliorates nasal inflammation by inhibiting eosinophil and mast cell activation and modulating the NF ‐κB/MAPKs signaling pathway
ConclusionUPE may have therapeutic potential for AR. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 16, 2024 Category: Allergy & Immunology Authors: Zhen Nan Yu,
Yan Jing Fan,
Thi Van Nguyen,
Chun Hua Piao,
Byung ‐Hoo Lee,
So‐Young Lee,
Hee Soon Shin,
Chang Ho Song,
Ok Hee Chai Tags: ORIGINAL ARTICLE Source Type: research
Anti ‐inflammatory potential of remimazolam: A laboratory and clinical investigation
ConclusionsRemimazolam exerted stronger anti-inflammatory effects than dexmedetomidine, and these effects were enhanced by its antioxidant properties, which may have affected postoperative CRP production. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 14, 2024 Category: Allergy & Immunology Authors: Shota Tsukimoto,
Atsuhiro Kitaura,
Hidetaka Kuroda,
Uno Imaizumi,
Fumihiko Yoshino,
Ayaka Yoshida,
Shinchi Nakao,
Noriyuki Ohta,
Yasuhumi Nakajima,
Takuro Sanuki Tags: ORIGINAL ARTICLE Source Type: research
Hmgcs2 is the hub gene in diabetic cardiomyopathy and is negatively regulated by Hmgcs2, promoting high glucose ‐induced cardiomyocyte injury
ConclusionsHmgcs2 had the most critical regulatory role in DCM. We for the first time reported that miR-363-5p inhibited Hmgcs2 expression, thereby alleviating HG-induced cardiomyocyte injury. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 13, 2024 Category: Allergy & Immunology Authors: Ying Wang,
Li ‐Feng Ping,
Fu‐Yan Bai,
Xin‐Huan Zhang,
Guang‐Hong Li Tags: ORIGINAL ARTICLE Source Type: research
Berberine: A natural modulator of immune cells in multiple sclerosis
There have been considerable changes discovered in multiple sclerosis (MS) regards to the function and frequency of T cell subsets such as Th1 cells, Th17 cells, Th2 cells, Treg cells, and dendritic cells (DCs). In the current research, we reviewed the outcomes of in vitro, experimental, and clinical investigations concerning the modulatory effects that Berberine pr ovides on the function and numbers of T cell subsets and DCs, as well as important cytokines that are involved in MS. AbstractBerberine is a benzylisoquinoline alkaloid found in such plants asBerberis vulgaris, Berberis aristata, and others, revealing a varie...
Source: Immunity, Inflammation and Disease - March 13, 2024 Category: Allergy & Immunology Authors: Esmaeil Yazdanpanah,
Sepehr Dadfar,
Alireza Shadab,
Niloufar Orooji,
MohammadHossein Nemati,
Alireza Pazoki,
Seyed ‐Alireza Esmaeili,
Rasoul Baharlou,
Dariush Haghmorad Tags: REVIEW ARTICLE Source Type: research
Elevated level of circulating calprotectin correlates with severity and high mortality in patients with COVID ‐19
ConclusionThis meta-analysis showed that calprotectin was elevated in patients with severe COVID-19, and this atypical inflammatory cytokine might serve as a useful biomarker to distinguish the severity of COVID-19 and predict the prognosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 13, 2024 Category: Allergy & Immunology Authors: Haoran Zhang,
Qingyu Zhang,
Kun Liu,
Zenong Yuan,
Xiqiang Xu,
Jun Dong Tags: ORIGINAL ARTICLE Source Type: research
