Association between preoperative systemic immune inflammation index and postoperative sepsis in patients with intestinal obstruction: A retrospective observational cohort study
ConclusionsA preoperative SII ＞ 1792.19 was a risk factor for postoperative sepsis in patients undergoing intestinal obstruction surgery. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Jirong Yang,
Taojia Ran,
Xiaoyu Lin,
Jinyan Xu,
Shaoli Zhou,
Chaojin Chen,
Pinjie Huang Tags: ORIGINAL ARTICLE Source Type: research
Intestinal mRNA expression analysis of polarity ‐related genes identified the discriminatory ability of CRB3 as a diagnostic marker for celiac disease
ConclusionThe aim of the current study was to evaluate the changes in the mRNA expression levels ofSCRIB,PRKCZ,LKB1, andCRB3 genes in the small intestinal biopsy samples of CD patients in comparison to the healthy control subjects. Our data uncover the importance of polarity-related genes (especiallyCRB3) in CD pahtomechanism, that may facilitate the planning of the future studies looking for finding innovative diagnostic and therapeutic strategies for CD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Tannaz Taraz,
Nastaran Asri,
Ehsan Nazemalhosseini ‐Mojarad,
Flora Forouzesh,
Mostafa Rezaei‐Tavirani,
Mohammad Rostami‐Nejad Tags: ORIGINAL ARTICLE Source Type: research
Autophagy ‐related genes polymorphism in hepatitis B virus‐associated hepatocellular carcinoma: A systematic review
ConclusionThe current study highlights the importance of rs2241880 in ATG16L1 and rs77859116, rs510432, and rs548234 in ATG5 for HBV-induced HCC. Additionally, some mutations in ATG16L1 and ATG5 were important in risk of HBV infection. The study highlights the gap of knowledge in the field of ATG polymorphisms in HBV infection and HBV-induced HCC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Parastoo Yousefi,
Alireza Tabibzadeh,
Abdulhussain Kadhim Jawaziri,
Mohsen Mehrjoo,
Mandana Akhavan,
Leila Allahqoli,
Hamid Salehiniya Tags: REVIEW ARTICLE Source Type: research
Three cases of systemic lupus erythematosus presenting with ischemic stroke as the initial symptom: Case reports and literature review
ConclusionIn young patients, particularly females presenting with ischemic stroke and especially in cases accompanied by hematologic or multisystemic involvement, there should be heightened vigilance for SLE-induced ischemic stroke. Early diagnosis and treatment significantly enhance patients' quality of life and survival rates. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 9, 2024 Category: Allergy & Immunology Authors: Na Li,
Xiaoxia Liu,
Pengjia Wu,
Jun Liu,
Pengyu Chen,
Jiashun Zeng Tags: ORIGINAL ARTICLE Source Type: research
Distinct cross talk of IL ‐17 & TGF ‐β with the immature CD11c+TRAF6(−/−)‐null myeloid dendritic cell‐derived osteoclast precursor (mDDOCp) may engage signaling toward an alternative pathway of osteoclastogenesis for arthritic bone loss in vivo
ConclusionThese results confirm and substantiate the validity of TRAF6( −/−)-null chimeras to address the significance of immature mCD11c+TRAP+DC-like OCs/mDDOCp subset for an alternative pathway of arthritic bone loss in vivo. Such CD11c+mDCs/mDDOCp-associated osteoclastogenesis through the step-wise twist-in-turns osteo-immune cross talks are thereby theme highlighted to depict a summative re-visitation proposed. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 8, 2024 Category: Allergy & Immunology Authors: Yen Chun G. Liu,
Andy Yen ‐Tung Teng Tags: ORIGINAL ARTICLE Source Type: research
Impact of occupational hazards on neurological health status in Pakistan: Challenges and recommendations
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 8, 2024 Category: Allergy & Immunology Authors: Zoaib Habib Tharwani,
Yumna Salman,
Maryam Irshad,
Mariam Adnan Rizvi,
Muhammad Hasanain,
Abdullah Malikzai Tags: COMMENTARY Source Type: research
Genetic determinants of SARS ‐CoV‐2 and the clinical outcome of COVID‐19 in Southern Bangladesh
ConclusionOur study identifies some risk factors such as age comorbidities (diabetes, hypertension, and renal disease) that are associated with severe COVID-19, providing valuable insight regarding prioritizing vaccination for high-risk individuals and allocating health care and resources. The findings of this work outlined the knowledge and mutational basis of SARS-CoV-2 for the next treatment steps. Further studies are needed to confirm the effects of structural and functional proteins of SARS-CoV-2 in detail for monitoring the emergence of new variants in future. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 7, 2024 Category: Allergy & Immunology Authors: Md. Mahbub Hasan,
Chayan Kumar Saha,
H. M. Hamidullah Mehedi,
Kallyan Chakma,
Asma Salauddin,
Md. Shakhawat Hossain,
Farjana Sharmen,
S. M. Rafiqul Islam,
Afroza Akter Tanni,
Farhana Yasmin,
Al ‐Shahriar Akash,
Mohammad Enayet Hossain,
Mojnu Tags: ORIGINAL ARTICLE Source Type: research
The role of the CX3CL1/CX3CR1 axis as potential inflammatory biomarkers in subjects with periodontitis and rheumatoid arthritis: A systematic review
ConclusionVery few studies highlight the role of the CX3CL1/CX3CR1 axis in the pathogenesis of periodontitis; however, increased levels of these chemokines are observed in different biological samples (GCF, gingival tissue, saliva, and serum) from subjects with periodontitis and RA compared with their healthy controls. Future studies should focus on long-term follow-up of subjects and monitoring changes in cytokine levels before and after periodontal therapy to deduce an appropriate interval in health and disease conditions. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 6, 2024 Category: Allergy & Immunology Authors: Mario A. Alarc ón‐Sánchez,
Julieta S. Becerra‐Ruiz,
Celia Guerrero‐Velázquez,
Seyed A. Mosaddad,
Artak Heboyan Tags: REVIEW ARTICLE Source Type: research
Therapeutic potential of dihydroartemisinin in mitigating radiation ‐induced lung injury: Inhibition of ferroptosis through Nrf2/HO‐1 pathways in mice
ConclusionDHA modulated the Nrf2/HO-1 pathway to prevent cellular ferroptosis, which reduced RILI. Therefore, DHA could be a potential drug for the treatment of RILI. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 5, 2024 Category: Allergy & Immunology Authors: Xin Ning,
Weidong Zhao,
Qiaoyuan Wu,
Cailan Wang,
Shixiong Liang Tags: ORIGINAL ARTICLE Source Type: research
Effects of myeloperoxidase on inflammatory responses with hypoxia in Citrobacter rodentium ‐infectious mice
ConclusionMPO plays an important role of the inflammatory responses in infectious enteritis and hypoxia in mice, and the loss of MPO may greatly reduce the body's inflammatory responses to fight diseases. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 3, 2024 Category: Allergy & Immunology Authors: Xiang Gao,
Yu Zhang,
Qinfang Zhu,
Ying Han,
Ruhan Jia,
Wei Zhang Tags: ORIGINAL ARTICLE Source Type: research
Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model
ConclusionSirt2 suppresses Treg function but also inhibits Treg polarization toward Treg/Th17 cells and Th17 cells. The ultimate effect of Sirt2 on colitis might depend on the balance among Tregs, Treg/Th17 cells, and Th17 cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 2, 2024 Category: Allergy & Immunology Authors: Liuqing Ge,
Min Xu,
Meifang Huang,
Shaoping Liu,
Zhidai Zhou,
Ziqin Xia,
Qiu Zhao,
Feng Zhou Tags: ORIGINAL ARTICLE Source Type: research
MiR ‐9‐enriched mesenchymal stem cells derived exosomes prevent cystitis‐induced bladder pain via suppressing TLR4/NLRP3 pathway in interstitial cystitis mice
ConclusionsThis study demonstrated that miR-9-enreched MSCs derived exosomes alleviate neuroinflammaiton and cystitis-induced bladder pain by inhibiting TLR4/NF ‑κb/NLRP3 signal pathway in interstitial cystitis mice, which is a promising strategy against cystitis-induced bladder pain. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 2, 2024 Category: Allergy & Immunology Authors: Xiangrong Cui,
Xingyu Bi,
Xiuping Zhang,
Zhiping Zhang,
Qin Yan,
Yanni Wang,
Xia Huang,
Xueqing Wu,
Xuan Jing,
Hongwei Wang Tags: ORIGINAL ARTICLE Source Type: research
Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury ‐induced neuropathic pain: Regulating extracellular signal‐regulated kinase and neuroinflammatory signaling pathways
ConclusionsThe data indicate that silencing SPP1 attenuates NP via inactivation of the ERK pathway, suggesting that SPP1 may be a promising target for NP treatment. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 2, 2024 Category: Allergy & Immunology Authors: Haiyu Xie,
Feng Lu,
Xiaoling Li,
Enfu Wang,
Jiao Mo,
Weidong Liang Tags: ORIGINAL ARTICLE Source Type: research
Knockdown of liver cancer cell ‐secreted exosomal PSMA5 controls macrophage polarization to restrain cancer progression by blocking JAK2/STAT3 signaling
ConclusionHCC cell-secreted exosomal PSMA5 knockdown hinders M2 polarization to suppress cancer progression by restraining JAK2/STAT3 signaling. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 2, 2024 Category: Allergy & Immunology Authors: Shujie Xie,
Xiang Li,
Jia Yan,
Hua Yu,
Shuhuai Chen,
Kana Chen Tags: ORIGINAL ARTICLE Source Type: research
Timing of initial symptom onset during milk and wheat challenges: A retrospective study
ConclusionThis multicenter study was the first to examine the time of symptom appearance during single-medium-dose milk and wheat challenges. Allergic reactions to wheat appear later than those for milk during OFC. For multiadministration OFC for wheat, the dosing interval should be longer than 60 min. Our findings can help improve the safety of OFCs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 2, 2024 Category: Allergy & Immunology Authors: Noriyuki Yanagida,
Takanori Minoura,
Sakura Sato,
Kyohei Takahashi,
Ken ‐ichi Nagakura,
Kiyotake Ogura,
Takaaki Itonaga,
Yoko Miura,
Naoko Fusayasu,
Motohiro Ebisawa Tags: ORIGINAL ARTICLE Source Type: research
