Regulation of cell proliferation and transdifferentiation compensates for ventilator ‐induced lung injury mediated by NLRP3 inflammasome activation
ConclusionsNLRP3 inflammasome activation mediated VILI, and VILI is alleviated after interfering with its activation, and inflammation and repair exist simultaneously in VILI. Clarifying these mechanisms is expected to provide theoretical guidance for alleviating VILI by inhibiting the inflammatory response and accelerating alveolar epithelial cell regeneration in the early stage. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 25, 2023 Category: Allergy & Immunology Authors: Huan Liu,
Xuepeng Yang,
Ge Liu Tags: REVIEW ARTICLE Source Type: research
Naringenin ameliorates collagen ‐induced arthritis through activating AMPK‐mediated autophagy in macrophages
ConclusionsThis study unveils a novel mechanism by which Naringenin may be used to treat RA. It demonstrates the therapeutic efficacy of Naringenin in a CIA model by reducing inflammation, modulating cytokine levels, and enhancing antioxidant capacity. Moreover, the activation of autophagy through the AMPK/ULK1 signaling pathway appears to play a critical role in Naringenin's anti-inflammatory effects. These findings suggest potential strategies for the development of anti-rheumatic medications based on Naringenin. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 21, 2023 Category: Allergy & Immunology Authors: Wei Zhang,
Yuan Zhang,
Jianguang Zhang,
Chunbiao Deng,
Chao Zhang Tags: ORIGINAL ARTICLE Source Type: research
Investigation of a synonymous mutation in Btk in a patient with agammaglobulinemia: A case report
ConclusionWe demonstrated reduced BTK protein expression confirming the pathogenicity of the variant and related our findings to genotype-phenotype relationship studies ina XLA caused by synonymous mutations. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 20, 2023 Category: Allergy & Immunology Authors: Cindy Srinivasan,
Afshin Shameli,
Bruce Ritchie,
Adil Adatia Tags: SHORT REPORT Source Type: research
Combined use of total glucosides of paeony and hydroxychloroquine in primary Sj ögren's syndrome: A systematic review
ConclusionTherefore, TGP + HCQ can be considered to be a potentially valid and safe combination for the treatment of pSS in the clinic. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 20, 2023 Category: Allergy & Immunology Authors: Aiping Zhang,
Shilei Chen,
Riyang Lin Tags: REVIEW ARTICLE Source Type: research
Buccopharyngeal route administered high polyphenolic olive oil and COVID ‐19: A pilot clinical trial
Conclusion and RelevanceAmong full-vaccinated adults recent infected with COVID-19, a daily intake of tiny quantities of oromucosal administered high polyphenolic olive oil before infection significantly improved the time to symptom resolution. This finding strongly support the appropriateness of further deep research on the use of oromucosal administered high polyphenolic olive oil as an effective immune strategy against COVID-19. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 20, 2023 Category: Allergy & Immunology Authors: Francisco Rodr íguez‐Argente,
María Alba‐Domínguez,
María P. Díaz‐Martínez,
Cristian Díaz‐Vergara,
Belén Díaz‐Márques,
Paloma Ferrero‐Ortega,
Ana C. Gil‐Adrados,
Lorena Gómez‐Bernardo,
Laura Gordo‐Murillo,
Elsa Humane Tags: ORIGINAL ARTICLE Source Type: research
Clinical utility of inflammatory biomarkers in COVID ‐19‐related sudden sensorineural hearing loss
ConclusionThe prognosis of COVID-19-related SSNHL was associated with inflammation. SII, NLR and CRP could serve as predictive markers of unfavorable outcomes in COVID-19-related SSNHL. SII may be considered an independent risk factor for poor prognosis in COVID-19-related SSNHL. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 18, 2023 Category: Allergy & Immunology Authors: Xu Zhang,
Li Chen,
Bing Guan Tags: ORIGINAL ARTICLE Source Type: research
ROR α overexpression reduced interleukin‐33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis
ConclusionROR α inhibits NLRP3 inflammasome in HNEpC, and attenuated mast cells degranulation and inflammation through autophagy in AR. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 18, 2023 Category: Allergy & Immunology Authors: Wangbo Yu,
Jingwei Du,
Lijuan Peng,
Tao Zhang Tags: ORIGINAL ARTICLE Source Type: research
Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta ‐analysis
ConclusionUC was causally related to ICH, but IBD and CD are not associated with ICH. The precise pathophysiological mechanism needs to be thoroughly investigated in more detail. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 17, 2023 Category: Allergy & Immunology Authors: Yanju Song,
Xuelun Zou,
Yi Zeng,
Le Zhang,
Xinfa Mao Tags: ORIGINAL ARTICLE Source Type: research
House dust mite subcutaneous immunotherapy has sustained long ‐term effectiveness on allergic rhinitis and asthma: A 10‐year follow‐up
ConclusionsSustained clinical efficacy is achieved 10 years after completion of depigmented-polymerized HDM, however, these findings were observed only if patients are treated for at least 3 years. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 14, 2023 Category: Allergy & Immunology Authors: Elena Rodriguez ‐Plata,
Ariel Callero Viera,
Monica Ruiz‐Garcia,
Aida Gomez‐Cardenosa,
Eva Nieto,
Jose Carlos García‐Robaina Tags: ORIGINAL ARTICLE Source Type: research
TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS) ‐induced inflammatory injury in endometritis by inhibiting NF‐kappaB activation
ConclusionTNIP2 alleviated endometritis by inhibiting the NF- κB pathway, suggesting a potential therapeutic target for endometritis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2023 Category: Allergy & Immunology Authors: Xinxin Qian,
Yan Wang,
Xingmei Li,
Yuewen Li,
Liping Li Tags: ORIGINAL ARTICLE Source Type: research
Differential expression of Type I interferon and inflammatory genes in SARS ‐CoV‐2‐infected patients treated with monoclonal antibodies
ConclusionThese data suggest that anti-S vaccinated patients have increased levels of innate immune genes compared to unvaccinated ones. Also, gene expression changes in IFN genes after mAbs administration are different according to the vaccination status of patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2023 Category: Allergy & Immunology Authors: Luca Maddaloni,
Letizia Santinelli,
Ginevra Bugani,
Elio G. Cacciola,
Alessandro Lazzaro,
Chiara M. Lofaro,
Sara Caiazzo,
Federica Frasca,
Matteo Fracella,
Camilla Ajassa,
Cristiana Leanza,
Anna Napoli,
Lilia Cinti,
Aurelia Gaeta,
Guido Anto Tags: ORIGINAL ARTICLE Source Type: research
Regulation of long noncoding RNAs in the pathogenesis and clinical implications of pituitary adenomas
ConclusionsThis review highlights recent progress in the study of lncRNAs in PA pathogenesis and their potential as diagnostic/prognostic biomarkers or therapeutic targets for PA patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2023 Category: Allergy & Immunology Authors: Ling Wang,
Dingkai Xu Tags: REVIEW ARTICLE Source Type: research
The CD2 –CD58 axis: A novel marker predicting poor prognosis in patients with low‐grade gliomas and potential therapeutic approaches
ConclusionOverall, our findings highlight the significant association between the CD2 –CD58 axis and poor survival in LGG patients. High CD58 expression is implicated in T cell-mediated immune responses as an immunosuppressive factor and affect inhibitory immune checkpoint genes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2023 Category: Allergy & Immunology Authors: Mingwei Wu,
Yiyuan Chen,
Gao Hua,
Liu Chunhui Tags: ORIGINAL ARTICLE Source Type: research
Association of genetic variations in FoxP3 gene with Graves' disease in a Southwest Chinese Han population
ConclusionOur findings suggest thatFoxP3/rs3761548 is significantly associated with female GD patients in a Southwest Chinese Han population. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2023 Category: Allergy & Immunology Authors: Guiqin Tan,
Guangbing Zheng,
Jiang Li,
Yingping Zhu,
Zhongzhi Liang,
Hua Li,
Hongsong Yu,
Xin Wang Tags: ORIGINAL ARTICLE Source Type: research
Potential biomarker for diagnosis and therapy of sepsis: Lactylation
ConclusionLactylation modification is directly regulated by glycolysis and lactate, and inhibition of glycolytic pathway-related enzymes can regulate the level of lactylation modification, and more importantly, lactylation modification can act on these enzymes to regulate their functions and feedback regulate the level of glycolysis, this finding provides more ideas for clinical treatment of sepsis. We use “epigenetic modification”, “glycolysis”, “lactate”, “lactylaiton” and “sepsis” as keywords and search the relevant literature through Pubmed and Web of science up to 2023. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2023 Category: Allergy & Immunology Authors: ZeXian Sun,
Yu Song,
Jie Li,
Yize Li,
YongHao Yu,
Xin Wang Tags: REVIEW ARTICLE Source Type: research
