The functional role of CST1 and CCL26 in asthma development

ConclusionOur results indicate that an overexpression ofCST1 andCCL26 cause a downregulation of interferon related genes and inflammatory proteins. It might cause a higher disease susceptibility, mainly for allergic asthma, asCCL26 is an agonist for CCR-3-carrying cells, such as eosinophils and Th2 lymphocytes, mostly active in allergic asthma.

Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Angela Hoyer, Sandip Chakraborty, Ingrid Lilienthal, Jon R. Konradsen, Shintaro Katayama, Cilla S öderhäll Tags: ORIGINAL ARTICLE Source Type: research