Development of heart failure with preserved ejection fraction is independent of eosinophils in a preclinical model

This is the first report to evaluate the role of eosinophils in heart failure with preserved ejection fraction (HFpEF), where a novel preclinical model of HFpEF and eosinophil-deficient mice was utilized. Results indicated that the development of HFpEF is independent of eosinophils, providing new insights into the roles of eosinophils in cardiovascular diseases. AbstractThe increasing burden of heart failure with preserved ejection fraction (HFpEF) has become a global health problem. HFpEF is characterized by systematic inflammation, cardiac metabolic remodeling, and fibrosis. Eosinophils act as an essential but generally overlooked subgroup of white blood cells, which participate in cardiac fibrosis, as reported in several recent studies. Herein, we explored the role of eosinophils in a “two-hit” preclinical HFpEF model. The peripheral eosinophil counts were comparable between the normal chow and HFpEF mice. Deficiency of eosinophils failed to alter the phenotype of HFpEF. Conclusively, the development of HFpEF is independent of eosinophils in terms of the functional, biochemic al, and histological results.

Source: Immunity, Inflammation and Disease - September 27, 2023 Category: Allergy & Immunology Authors: Qi Pan, Cheng Chen, Zhaoting Gong, Guihao Chen, Yuejin Yang Tags: SHORT REPORT Source Type: research