Abstracts from Hydrocephalus 2021: The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 21, 2021 Category: Neurology Tags: Meeting abstracts Source Type: research
Abstracts from the Virtual Symposium “Signal Transduction at the Blood–Brain Barriers”
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 17, 2021 Category: Neurology Tags: Meeting abstracts Source Type: research
Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
In ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU d... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 14, 2021 Category: Neurology Authors: Nienke R. Wevers, Arya Lekshmi Nair, Tania M. Fowke, Maria Pontier, Dhanesh G. Kasi, Xandor M. Spijkers, Charlie Hallard, Gwena ëlle Rabussier, Remko van Vught, Paul Vulto, Helga E. de Vries and Henriëtte L. Lanz Tags: Research Source Type: research
Quantitative analysis of macroscopic solute transport in the murine brain
Understanding molecular transport in the brain is critical to care and prevention of neurological disease and injury. A key question is whether transport occurs primarily by diffusion, or also by convection or... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 7, 2021 Category: Neurology Authors: Lori A. Ray, Martin Pike, Matthew Simon, Jeffrey J. Iliff and Jeffrey J. Heys Tags: Research Source Type: research
Next-generation in vitro blood –brain barrier models: benchmarking and improving model accuracy
With the limitations associated with post-mortem tissue and animal models, In vitro BBB models enable precise control of independent variables and microenvironmental cues, and hence play an important role in s... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 7, 2021 Category: Neurology Authors: Raleigh M. Linville and Peter C. Searson Tags: Commentary Source Type: research
Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain
Little is known about the extent of drug entry into developing brain, when administered to pregnant and lactating women. Lithium is commonly prescribed for bipolar disorder. Here we studied transfer of lithium... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 7, 2021 Category: Neurology Authors: Shene Yi-Shiuan Chiou, Kai Kysenius, Yifan Huang, Mark David Habgood, Liam M. Koehn, Fiona Qiu, Peter J. Crouch, Swati Varshney, Katherine Ganio, Katarzyna Magdalena Dziegielewska and Norman Ruthven Saunders Tags: Research Source Type: research
Capsule-dependent impact of MAPK signalling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis
The Gram-negative bacterium Neisseria meningitidis (Nm) can cause meningitis in humans, but the host signalling pathways manipulated by Nm during central nervous system (CNS) entry are not completely understood. (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 4, 2021 Category: Neurology Authors: Rosanna Herold, Ren é Scholtysik, Selina Moroniak, Christel Weiss, Hiroshi Ishikawa, Horst Schroten and Christian Schwerk Tags: Research Source Type: research
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological condition of unresolved etiology characterized by a clinical triad of symptoms; gait disturbances, urinary incontinence,... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 4, 2021 Category: Neurology Authors: Sara Diana Lolansen, Nina Rostgaard, S øren Norge Andreassen, Anja Hviid Simonsen, Marianne Juhler, Steen Gregers Hasselbalch and Nanna MacAulay Tags: Research Source Type: research
Microdialysis and microperfusion electrodes in neurologic disease monitoring
Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 1, 2021 Category: Neurology Authors: Luke A. Stangler, Abbas Kouzani, Kevin E. Bennet, Ludovic Dumee, Michael Berk, Gregory A. Worrell, Steven Steele, Terence C. Burns and Charles L. Howe Tags: Review Source Type: research
Physical exercise and goal attainment after shunt surgery in idiopathic normal pressure hydrocephalus: a randomised clinical trial
Rehabilitation in iNPH is suggested to be an important factor to improve patients ’ functions but there are lack of clinical trials evaluating the effect of rehabilitation interventions after shunt surgery in i... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 22, 2021 Category: Neurology Authors: Johanna Rydja, Lena Koll én, Per Hellström, Katarina Owen, Åsa Lundgren Nilsson, Carsten Wikkelsø, Mats Tullberg and Fredrik Lundin Tags: Research Source Type: research
The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown
Chronic mild hypoxia (CMH, 8% O2) stimulates robust vascular remodelling in the brain, but it also triggers transient vascular disruption. This raises the fundamental question: is the vascular leak an unwanted si... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 17, 2021 Category: Neurology Authors: Sebok K. Halder and Richard Milner Tags: Research Source Type: research
A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments
Many animal models have been used to study the pathophysiology of hydrocephalus; most of these have been rodent models whose lissencephalic cerebral cortex may not respond to ventriculomegaly in the same way a... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 8, 2021 Category: Neurology Authors: James P. McAllister II, Michael R. Talcott, Albert M. Isaacs, Sarah H. Zwick, Maria Garcia-Bonilla, Leandro Castaneyra-Ruiz, Alexis L. Hartman, Ryan N. Dilger, Stephen A. Fleming, Rebecca K. Golden, Diego M. Morales, Carolyn A. Harris and David D. Limbric Tags: Research Source Type: research
Tachycardia and hypertension enhance tracer efflux from the spinal cord
Disruption of cerebrospinal fluid (CSF)/interstitial fluid (ISF) exchange in the spinal cord is likely to contribute to central nervous system (CNS) diseases that involve abnormal fluid accumulation, including... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 26, 2021 Category: Neurology Authors: Shinuo Liu, Lynne E. Bilston, Marcus A. Stoodley and Sarah J. Hemley Tags: Research Source Type: research
Influence of traumatic brain injury on extracellular tau elimination at the blood –brain barrier
Repetitive head trauma has been associated with the accumulation of tau species in the brain. Our prior work showed brain vascular mural cells contribute to tau processing in the brain, and that these cells pr... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 26, 2021 Category: Neurology Authors: Maxwell Eisenbaum, Andrew Pearson, Arissa Gratkowski, Benoit Mouzon, Michael Mullan, Fiona Crawford, Joseph Ojo and Corbin Bachmeier Tags: Research Source Type: research
Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review
With the introduction of endovascular thrombectomy (EVT), a new era for treatment of acute ischemic stroke (AIS) has arrived. However, despite the much larger recanalization rate as compared to thrombolysis al... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 19, 2021 Category: Neurology Authors: I. A. Mulder, E. T. van Bavel, H. E. de Vries and J. M. Coutinho Tags: Review Source Type: research
