Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 2, 2021 Category: Neurology Authors: Betsaida Ojeda-P érez, José A. Campos-Sandoval, María García-Bonilla, Casimiro Cárdenas-García, Patricia Páez-González and Antonio J. Jiménez Tags: Research Source Type: research
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging
White matter hyperintensities (WMHs) are one of the hallmarks of cerebral small vessel disease (CSVD), but the pathological mechanisms underlying WMHs remain unclear. Recent studies suggest that extracellular ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 30, 2021 Category: Neurology Authors: Xinfeng Yu, Xinzhen Yin, Hui Hong, Shuyue Wang, Yeerfan Jiaerken, Fan Zhang, Ofer Pasternak, Ruiting Zhang, Linglin Yang, Min Lou, Minming Zhang and Peiyu Huang Tags: Research Source Type: research
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers
The blood –brain barrier (BBB) plays a critical role in protecting the central nervous system (CNS) from blood-borne agents and potentially harmful xenobiotics. Our group’s previous data has shown that tobacco ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 22, 2021 Category: Neurology Authors: Hossam Kadry, Behnam Noorani, Ulrich Bickel, Thomas J. Abbruscato and Luca Cucullo Tags: Research Source Type: research
Brain endothelial LRP1 maintains blood –brain barrier integrity
The entry of blood-borne molecules into the brain is restricted by the blood –brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 19, 2021 Category: Neurology Authors: Steffen E. Storck, Magdalena Kurtyka and Claus U. Pietrzik Tags: Short paper Source Type: research
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimina... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 2, 2021 Category: Neurology Authors: Rebecca Faresj ö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin and Stina Syvänen Tags: Research Source Type: research
Intracranial pressure waveform characteristics in idiopathic normal pressure hydrocephalus and late-onset idiopathic aqueductal stenosis
Idiopathic normal pressure hydrocephalus (iNPH) and late-onset idiopathic aqueductal stenosis (LIAS) are two forms of chronic adult hydrocephalus of different aetiology. We analysed overnight intracranial pres... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 26, 2021 Category: Neurology Authors: Lauren M. Green, Thomas Wallis, Martin U. Schuhmann and Matthias Jaeger Tags: Research Source Type: research
Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood –brain barrier and neurovascular unit
This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid a... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 21, 2021 Category: Neurology Authors: Richard F. Keep, Hazel C. Jones and Lester R. Drewes Tags: Editorial Source Type: research
Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure hydrocephalus
Idiopathic normal pressure hydrocephalus (iNPH) is a reversible CNS disease characterized by disturbed cerebrospinal fluid (CSF) dynamics. Changes in the extracellular matrix (ECM) composition might be involve... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 13, 2021 Category: Neurology Authors: Karolina Minta, Anna Jeppsson, Gunnar Brinkmalm, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Mats Tullberg and Ulf Andreasson Tags: Research Source Type: research
Serial Tap Test of patients with idiopathic normal pressure hydrocephalus: impact on cognitive function and its meaning
Idiopathic normal pressure hydrocephalus (INPH) is characterized by gait disturbance, urinary incontinence and cognitive decline. Symptoms are potentially reversible and treatment is based on cerebrospinal flu... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 6, 2021 Category: Neurology Authors: Samanta Fabr ício Blattes da Rocha, Pedro André Kowacs, Ricardo Krause Martinez de Souza, Matheus Kahakura Franco Pedro, Ricardo Ramina and Hélio A. Ghizoni Teive Tags: Research Source Type: research
Reduction in pericyte coverage leads to blood –brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion
Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small vessel disease (CSVD). CCH is strongly associated with blood –brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD.... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 5, 2021 Category: Neurology Authors: Zhengyu Sun, Chenhao Gao, Dandan Gao, Ruihua Sun, Wei Li, Fengyu Wang, Yanliang Wang, Huixia Cao, Guoyu Zhou, Jiewen Zhang and Junkui Shang Tags: Research Source Type: research
Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia
Idiopathic normal pressure hydrocephalus (iNPH) is considered an age-dependent chronic communicating hydrocephalus associated with cerebrospinal fluid (CSF) malabsorption; however, the aetiology of ventricular... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 19, 2021 Category: Neurology Authors: Shigeki Yamada, Masatsune Ishikawa and Kazuhiko Nozaki Tags: Review Source Type: research
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review
Although widely used in the evaluation of the diseased, normal intracranial pressure and lumbar cerebrospinal fluid pressure remain sparsely documented. Intracranial pressure is different from lumbar cerebrosp... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 13, 2021 Category: Neurology Authors: Nicolas Hernandez Norager, Markus Harboe Olsen, Sarah Hornshoej Pedersen, Casper Schwartz Riedel, Marek Czosnyka and Marianne Juhler Tags: Research Source Type: research
Evaluating the cerebrospinal fluid tap test with the Hellstr öm iNPH scale for patients with idiopathic normal pressure hydrocephalus
The cerebrospinal fluid tap test (CSF TT) is used for selecting shunt surgery candidates among patients with idiopathic normal pressure hydrocephalus (iNPH). We aimed to evaluate the predictive value of the CS... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 7, 2021 Category: Neurology Authors: Johanna Rydja, Andreas Eleftheriou and Fredrik Lundin Tags: Research Source Type: research
Epigenetics in blood –brain barrier disruption
The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transpo... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 6, 2021 Category: Neurology Authors: Stephanie A. Ihezie, Iny Elizebeth Mathew, Devin W. McBride, Ari Dienel, Spiros L. Blackburn and Peeyush Kumar Thankamani Pandit Tags: Review Source Type: research
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases
Several central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by phase-contrast magnetic resonance imaging (MRI). T... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 1, 2021 Category: Neurology Authors: Per Kristian Eide, Lars Magnus Valnes, Erika Kristina Lindstr øm, Kent-Andre Mardal and Geir Ringstad Tags: Research Source Type: research
