Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood –brain barrier in hypertriglyceridemia
Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood –brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chr... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 7, 2023 Category: Neurology Authors: Be áta Barabási, Lilla Barna, Ana Raquel Santa-Maria, András Harazin, Réka Molnár, András Kincses, Judit P. Vigh, Brigitta Dukay, Miklós Sántha, Melinda E. Tóth, Fruzsina R. Walter, Mária A. Deli and Zsófia Hoyk Tags: Research Source Type: research
Epigenetics and stroke: role of DNA methylation and effect of aging on blood –brain barrier recovery
Incomplete recovery of blood –brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests that epigenetic factors play a si... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 28, 2023 Category: Neurology Authors: Chelsea M. Phillips, Svetlana M. Stamatovic, Richard F. Keep and Anuska V. Andjelkovic Tags: Research Source Type: research
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC –MS/MS technique
Potential biomarkers for neuropsychiatric disorders are cerebrospinal fluid (CSF) monoamines and their corresponding precursors and metabolites. During CSF sampling, CSF flows towards the lumbar sampling site ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 13, 2023 Category: Neurology Authors: Celien Tigchelaar, Willemien D. Muller, Sawal D. Atmosoerodjo, Klaas J. Wardenaar, Ido P. Kema, Anthony R. Absalom and Martijn van Faassen Tags: Research Source Type: research
Impact of aging on meningeal gene expression
The three-layered meninges cover and protect the central nervous system and form the interface between cerebrospinal fluid and the brain. They are host to a lymphatic system essential for maintaining fluid dyn... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 6, 2023 Category: Neurology Authors: Melanie Neutzner, Corina Kohler, Stephan Frank, Hanspeter E. Killer and Albert Neutzner Tags: Research Source Type: research
Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors
Regulation of cerebral blood flow (CBF) directly influence brain functions and dysfunctions and involves complex mechanisms, including neurovascular coupling (NVC). It was suggested that the serine protease ti... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 3, 2023 Category: Neurology Authors: Jonathane Furon, Merv é Yetim, Elsa Pouettre, Sara Martinez de Lizarrondo, Eric Maubert, Yannick Hommet, Laurent Lebouvier, Ze Zheng, Carine Ali and Denis Vivien Tags: Research Source Type: research
The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression
Brain microvascular endothelial cells (BMECs) play a major role in the blood –brain barrier (BBB), and are critical for establishing an in vitro BBB model. Currently, iPSC-derived BMECs (iBMECs) have been used ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 2, 2023 Category: Neurology Authors: Hongyan Zhang, Tomoko Yamaguchi and Kenji Kawabata Tags: Research Source Type: research
Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model
Age-related changes in the cerebrovasculature, including blood –brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothel... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 1, 2023 Category: Neurology Authors: Hyejeong Kim, Minyoung Noh, Haiying Zhang, Yeomyeong Kim, Songyi Park, Jeongeun Park and Young-Guen Kwon Tags: Research Source Type: research
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood –brain barrier
The multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP/ABCG2) contribute to the blood –brain barrier (BBB), protecting the brain from drug e... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 31, 2023 Category: Neurology Authors: Phetcharawan Lye, Enrrico Bloise and Stephen G. Matthews Tags: Research Source Type: research
Resting-state functional-MRI in iNPH: can default mode and motor networks changes improve patient selection and outcome? Preliminary report
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and partially reversible form of dementia, characterized by impaired interactions between multiple brain regions. Because of the presence of com... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 26, 2023 Category: Neurology Authors: Sara Fabbro, Daniele Piccolo, Maria Caterina Vescovi, Daniele Bagatto, Yan Tereshko, Enrico Belgrado, Marta Maieron, Maria Cristina De Colle, Miran Skrap and Francesco Tuniz Tags: Research Source Type: research
Differential proteomic profile of lumbar and ventricular cerebrospinal fluid
Pathological cerebral conditions may manifest in altered composition of the cerebrospinal fluid (CSF). Although diagnostic CSF analysis seeks to establish pathological disturbances in the brain proper, CSF is ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 21, 2023 Category: Neurology Authors: Nina Rostgaard, Markus Harboe Olsen, Maud Ottenheijm, Lylia Drici, Anja Hviid Simonsen, Peter Plomgaard, Hanne Gredal, Helle Harding Poulsen, Henrik Zetterberg, Kaj Blennow, Steen Gregers Hasselbalch, Nanna MacAulay and Marianne Juhler Tags: Research Source Type: research
Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging
Detecting changes in pulsatile cerebrospinal fluid (CSF) flow may assist clinical management decisions, but spinal CSF flow is relatively understudied. Traumatic spinal cord injuries (SCI) often cause spinal c... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 18, 2023 Category: Neurology Authors: Madeleine Amy Bessen, Christine Diana Gayen, Ryan David Quarrington, Angela Catherine Walls, Anna Victoria Leonard, Vartan Kurtcuoglu and Claire Frances Jones Tags: Research Source Type: research
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"
The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The worksh... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 13, 2023 Category: Neurology Authors: Jason K. Karimy, Jessie C. Newville, Cameron Sadegh, Jill A. Morris, Edwin S. Monuki, David D. Limbrick Jr., James P. McAllister II, Jenna E. Koschnitzky, Maria K. Lehtinen and Lauren L. Jantzie Tags: Review Source Type: research
Abstracts from Hydrocephalus 2022: the Fourteenth Meeting of the Hydrocephalus Society
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 13, 2023 Category: Neurology Tags: Meeting Abstracts Source Type: research
Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in idiopathic intracranial hypertension
Impaired cerebrospinal fluid (CSF) homeostasis is central to the pathogenesis of idiopathic intracranial hypertension (IIH), although the precise mechanisms involved are still not completely understood. The ai... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 11, 2023 Category: Neurology Authors: Sinah Engel, Johannes Halcour, Erik Ellwardt, Timo Uphaus, Falk Steffen, Frauke Zipp, Stefan Bittner and Felix Luessi Tags: Research Source Type: research
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells
Our previous study demonstrated that M1 macrophages could impair tight junctions (TJs) between vascular endothelial cells by secreting interleukin-6 (IL-6) after spinal cord injury (SCI). Tocilizumab, as a hum... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 9, 2023 Category: Neurology Authors: Yang Luo, Fei Yao, Yi Shi, Zhenyu Zhu, Zhaoming Xiao, Xingyu You, Yanchang Liu, Shuisheng Yu, Dasheng Tian, Li Cheng, Meige Zheng and Juehua Jing Tags: Research Source Type: research
