Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome
The short and long-term health effects of JUUL electronic cigarette (e-Cig) are largely unknown and warrant extensive research. We hypothesized that JUUL exposure could cause cerebrovascular toxicities impacti... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 9, 2022 Category: Neurology Authors: Ali Ehsan Sifat, Sabrina Rahman Archie, Saeideh Nozohouri, Heidi Villalba, Yong Zhang, Sejal Sharma, Yashwardhan Ghanwatkar, Bhuvaneshwar Vaidya, David Mara, Luca Cucullo and Thomas J. Abbruscato Tags: Research Source Type: research
Characterization of passive permeability after low intensity focused ultrasound mediated blood –brain barrier disruption in a preclinical model
Systemic drug delivery to the central nervous system is limited by presence of the blood –brain barrier (BBB). Low intensity focused ultrasound (LiFUS) is a non-invasive technique to disrupt the BBB, though the... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 8, 2022 Category: Neurology Authors: Tasneem A. Arsiwala, Samuel A. Sprowls, Kathryn E. Blethen, Ross A. Fladeland, Cullen P. Wolford, Brooke N. Kielkowski, Morgan J. Glass, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Manish Ranjan, Victor Finomore, Ali Rezai and Paul R. Lockman Tags: Research Source Type: research
ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells
To investigate whether DNA active demethylase TET regulates the expression of tight junction proteins in endothelial cells of the blood –brain barrier (BBB). (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 8, 2022 Category: Neurology Authors: Lan Wang, Bei Mao, Keyang Fan, Renqiang Sun, Jialong Zhang, Huazheng Liang and Ying Liu Tags: Research Source Type: research
In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
Idiopathic normal pressure hydrocephalus (iNPH) is a clinico-radiological syndrome of elderly individuals likely sustained by different neurodegenerative changes as copathologies. Since iNPH is a potentially r... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 7, 2022 Category: Neurology Authors: Giulia Giannini, Simone Baiardi, Sofia Dellavalle, Corrado Zenesini, Sabina Cevoli, Nils Danner, Henna-Kaisa Jyrkk änen, Marcello Rossi, Barbara Polischi, Corinne Quadalti, Camilla Stefanini, Pietro Cortelli, David Milletti, Sanna-Kaisa Herukka, Giorgio Tags: Research Source Type: research
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
In this study, we hypothesized that N-methyl-D-aspartate (NMDA)... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 6, 2022 Category: Neurology Authors: Kyu-Sung Kim, Min Tae Jeon, Eun Seon Kim, Chan Hee Lee and Do-Geun Kim Tags: Research Source Type: research
Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1
A range of neurological pathologies may lead to secondary hydrocephalus. Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as specific and efficient pharmacological options ar... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 6, 2022 Category: Neurology Authors: Trine L. Toft-Bertelsen, Dagne Barbuskaite, Eva Kjer Heerfordt, Sara Diana Lolansen, S øren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Martin Fredensborg Rath, Marianne Juhler and Nanna MacAulay Tags: Research Source Type: research
Distinct volumetric features of cerebrospinal fluid distribution in idiopathic normal-pressure hydrocephalus and Alzheimer ’s disease
The aims of the study were to measure the cerebrospinal fluid (CSF) volumes in the lateral ventricle, high-convexity subarachnoid space, and Sylvian fissure region in patients with idiopathic normal-pressure h... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 1, 2022 Category: Neurology Authors: Jaehwan Han, Myoung Nam Kim, Ho-Won Lee, Shin Young Jeong, Sang-Woo Lee, Uicheul Yoon and Kyunghun Kang Tags: Research Source Type: research
Microglia-derived CCL2 has a prime role in neocortex neuroinflammation
In myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), several areas of demyelination are detectable in mouse cerebral cortex, where neuroinflammation events are ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 30, 2022 Category: Neurology Authors: Mariella Errede, Tiziana Annese, Valentina Petrosino, Giovanna Longo, Francesco Girolamo, Ignazio de Trizio, Antonio d ’Amati, Antonio Uccelli, Nicole Kerlero de Rosbo and Daniela Virgintino Tags: Research Source Type: research
Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics
The pressure difference between the eye and brain in upright postures may be affected by compartmentalization of the optic nerve subarachnoid space (ONSAS). Both pressure and deformation will depend on the mic... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 30, 2022 Category: Neurology Authors: Petter Holmlund, Karen-Helene St øverud and Anders Eklund Tags: Research Source Type: research
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the details underlying the molecular... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 29, 2022 Category: Neurology Authors: Eva K. Oernbo, Annette B. Steffensen, Pooya Razzaghi Khamesi, Trine L. Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J. Gerkau, Katerina Tritsaris, Anja H. Simonsen, Sara D. Lolansen, S øren N. Andreassen, Steen G. Hasselbalch, Thomas Zeut Tags: Research Source Type: research
A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption
Endothelial cells (ECs) in cerebral vessels are considered the primary targets in acute hemorrhagic brain injuries. EC dysfunction can aggravate neuronal injuries by causing secondary inflammatory responses an... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 26, 2022 Category: Neurology Authors: Min Joung Lee, Jiebo Zhu, Jong Hun An, Seong Eun Lee, Tae Yeon Kim, Eungseok Oh, Yea Eun Kang, Woosuk Chung and Jun Young Heo Tags: Research Source Type: research
Role of aging in Blood –Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
COVID-19, which is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), has resulted in devastating morbidity and mortality worldwide due to lethal pneumonia and respiratory distress. In ad... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 18, 2022 Category: Neurology Authors: Daniel Adesse, Luis Gladulich, Liandra Alvarez-Rosa, Michele Siqueira, Anne Caroline Marcos, Marialice Heider, Caroline Soares Motta, Silvia Torices, Michal Toborek and Joice Stipursky Tags: Review Source Type: research
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Posthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic events such as intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH). Treatment is limited to surgical diversion of the ce... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 10, 2022 Category: Neurology Authors: Sara Diana Lolansen, Nina Rostgaard, Dagne Barbuskaite, Tenna Capion, Markus Harboe Olsen, Nicolas H. Norager, Frederik Vilhardt, S øren Norge Andreassen, Trine L. Toft-Bertelsen, Fenghui Ye, Marianne Juhler, Richard F. Keep and Nanna MacAulay Tags: Research Source Type: research
Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders
Infectious and immunological theories of schizophrenia have been discussed for over a century. Contradictory results for infectious agents in association with schizophrenia spectrum disorders (SSDs) were repor... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 29, 2022 Category: Neurology Authors: Kimon Runge, Agnes Balla, Bernd L. Fiebich, Simon J. Maier, Benjamin Pankratz, Andrea Schlump, Kathrin Nickel, Rick Dersch, Katharina Domschke, Ludger Tebartz van Elst and Dominique Endres Tags: Research Source Type: research
Extracellular vesicles through the blood –brain barrier: a review
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood –Brain barrier (BBB) in a bidirectional ma... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 25, 2022 Category: Neurology Authors: H éctor M. Ramos-Zaldívar, Iva Polakovicova, Edison Salas-Huenuleo, Alejandro H. Corvalán, Marcelo J. Kogan, Claudia P. Yefi and Marcelo E. Andia Tags: Review Source Type: research
