Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood –brain barrier constitute an important ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 9, 2023 Category: Neurology Authors: Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Elisabeth Helena Bruun, Birger Brodin and Morten S. Nielsen Tags: Research Source Type: research
The new insight into the inflammatory response following focused ultrasound-mediated blood –brain barrier disruption
Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not, and the biological responses after FUS-BBBD tri... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 23, 2022 Category: Neurology Authors: Hyo Jin Choi, Mun Han, Hyeon Seo, Chan Yuk Park, Eun-Hee Lee and Juyoung Park Tags: Research Source Type: research
Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach
In patients with central nervous system (CNS) infections identification of the causative pathogen is important for treatment. Metagenomic next-generation sequencing techniques are increasingly being applied to... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 22, 2022 Category: Neurology Authors: Cormac M. Kinsella, Arthur W. D. Edridge, Ingeborg E. van Zeggeren, Martin Deijs, Diederik van de Beek, Matthijs C. Brouwer and Lia van der Hoek Tags: Research Source Type: research
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies
Cerebrospinal fluid (CSF) is an essential and critical component of the central nervous system (CNS). According to the concept of the “third circulation” originally proposed by Cushing, CSF is mainly produced ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 15, 2022 Category: Neurology Authors: Guojun Liu, Antonio Ladr ón-de-Guevara, Yara Izhiman, Maiken Nedergaard and Ting Du Tags: Review Source Type: research
Blood and cerebrospinal fluid flow oscillations measured with real-time phase-contrast MRI: breathing mode matters
Cervical blood and cerebrospinal fluid (CSF) flow rates can be quantified with Phase-contrast (PC) MRI, which is routinely used for clinical studies. Previous MRI studies showed that venous and CSF flow altera... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 14, 2022 Category: Neurology Authors: Maria Marcella Lagan à, Sonia Di Tella, Francesca Ferrari, Laura Pelizzari, Marta Cazzoli, Noam Alperin, Ning Jin, Domenico Zacà, Giuseppe Baselli and Francesca Baglio Tags: Research Source Type: research
Brain pharmacokinetics of mono- and bispecific amyloid- β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis
Treatment with amyloid- β (Aβ) targeting antibodies is a promising approach to remove Aβ brain pathology in Alzheimer's disease (AD) and possibly even slow down or stop progression of the disease. One of the ma... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 12, 2022 Category: Neurology Authors: Ulrika Julku, Mengfei Xiong, Elin Wik, Sahar Roshanbin, Dag Sehlin and Stina Syv änen Tags: Research Source Type: research
Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism
Glucose transport from the blood into the brain is tightly regulated by brain microvascular endothelial cells (BMEC), which also use glucose as their primary energy source. To study how BMEC glucose transport ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 9, 2022 Category: Neurology Authors: Callie M. Weber, Bilal Moiz, Sophia M. Zic, Viviana Alp ízar Vargas, Andrew Li and Alisa Morss Clyne Tags: Research Source Type: research
Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins
Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor inter... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 3, 2022 Category: Neurology Authors: Jingsong Ruan, Karen K. McKee, Peter D. Yurchenco and Yao Yao Tags: Research Source Type: research
Is plasma amyloid- β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?
A reduced amyloid- β (Aβ)42/40 peptide ratio in blood plasma represents a peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer’s disease brains. The magnitude of the measurable effect in... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 3, 2022 Category: Neurology Authors: Hans-Wolfgang Klafki, Barbara Morgado, Oliver Wirths, Olaf Jahn, Chris Bauer, Hermann Esselmann, Johannes Schuchhardt and Jens Wiltfang Tags: Research Source Type: research
Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus
Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid in the cerebral ventricles and causes motor impairments. The mechanisms underlying the motor changes remain elusive. Enlargement o... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 27, 2022 Category: Neurology Authors: Li-Jin Chen, Jeng-Rung Chen and Guo-Fang Tseng Tags: Research Source Type: research
Transcriptomic analysis of a 3D blood –brain barrier model exposed to disturbed fluid flow
Cerebral aneurysms are more likely to form at bifurcations in the vasculature, where disturbed fluid is prevalent due to flow separation at sufficiently high Reynolds numbers. While previous studies have demon... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 24, 2022 Category: Neurology Authors: Nesrine Bouhrira, Brandon J. DeOre, Kiet A. Tran and Peter A. Galie Tags: Research Source Type: research
Novel localization of folate transport systems in the murine central nervous system
Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals. Folate transport... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 23, 2022 Category: Neurology Authors: Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson and Reina Bendayan Tags: Brief Report Source Type: research
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis
Disruption of brain barriers is considered to be involved in the pathogenesis of neuronal surface antibody-associated autoimmune encephalitis (NSAE), but few studies have focused on their relationship. We aime... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 23, 2022 Category: Neurology Authors: Qi-Lun Lai, Meng-Ting Cai, Yang Zheng, Gao-Li Fang, Bing-Qing Du, Chun-Hong Shen, Jia-Jia Wang, Qin-Jie Weng and Yin-Xi Zhang Tags: Research Source Type: research
Correction: Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 17, 2022 Category: Neurology Authors: Yong Zhang, Sabrina Rahman Archie, Yashwardhan Ghanwatkar, Sejal Sharma, Saeideh Nozohouri, Elizabeth Burks, Alexander Mdzinarishvili, Zijuan Liu and Thomas J. Abbruscato Tags: Correction Source Type: research
Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers
Apparent permeability of the blood brain barrier to hydrophilic markers has been shown to be higher in the developing brain. Apart from synthesis in situ, any substance detected in the brain parenchyma can origin... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 14, 2022 Category: Neurology Authors: Fiona Qiu, Yifan Huang, Norman R. Saunders, Mark D. Habgood and Katarzyna M. Dziegielewska Tags: Research Source Type: research
