The blood –brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
The response of the blood –brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, a... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 11, 2022 Category: Neurology Authors: Peter Sol ár, Alemeh Zamani, Klaudia Lakatosová and Marek Joukal Tags: Review Source Type: research
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review
Intraventricular hemorrhage (IVH) is a significant cause of morbidity and mortality in both neonatal and adult populations. IVH not only causes immediate damage to surrounding structures by way of mass effect ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 1, 2022 Category: Neurology Authors: Katherine G. Holste, Fan Xia, Fenghui Ye, Richard F. Keep and Guohua Xi Tags: Review Source Type: research
Non-coding RNAs in the regulation of blood –brain barrier functions in central nervous system disorders
The blood –brain barrier (BBB) is an essential component of the neurovascular unit that controls the exchanges of various biological substances between the blood and the brain. BBB damage is a common feature of... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 26, 2022 Category: Neurology Authors: Ping Sun, Milton H. Hamblin and Ke-Jie Yin Tags: Review Source Type: research
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited
Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is continuously replenished by net fluid extraction from the vasculature by the secretory action of the choroid plexus ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 22, 2022 Category: Neurology Authors: Nanna MacAulay, Richard F. Keep and Thomas Zeuthen Tags: Review Source Type: research
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults
Recent studies have suggested alternative cerebrospinal fluid (CSF) clearance pathways for brain parenchymal metabolic waste products. One fundamental but relatively under-explored component of these pathways ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 21, 2022 Category: Neurology Authors: Kilian Hett, Colin D. McKnight, Jarrod J. Eisma, Jason Elenberger, Jennifer S. Lindsey, Ciaran M. Considine, Daniel O. Claassen and Manus J. Donahue Tags: Research Source Type: research
Exploring ITM2A as a new potential target for brain delivery
Integral membrane protein 2A (ITM2A) is a transmembrane protein expressed in a variety of tissues; little is known about its function, particularly in the brain. ITM2A was found to be highly enriched in human bra... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 21, 2022 Category: Neurology Authors: C éline Cegarra, C. Chaves, C. Déon, T. M. Do, B. Dumas, A. Frenzel, P. Kuhn, V. Roudieres, J. C. Guillemot and D. Lesuisse Tags: Research Source Type: research
Expression and functions of adenylyl cyclases in the CNS
Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In th... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 20, 2022 Category: Neurology Authors: Karan Devasani and Yao Yao Tags: Review Source Type: research
Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures
Neurodegenerative diseases (NDs) are an accelerating global health problem. Nevertheless, the stronghold of the brain- the blood –brain barrier (BBB) prevents drug penetrance and dwindles effective treatments. ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 17, 2022 Category: Neurology Authors: Sara Hernando, Polyxeni Nikolakopoulou, Dimitrios Voulgaris, Rosa Maria Hernandez, Manoli Igartua and Anna Herland Tags: Research Source Type: research
Decreased CSF clearance and increased brain amyloid in Alzheimer ’s disease
In sporadic Alzheimer ’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not well established in living humans. CSF clearance,... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 14, 2022 Category: Neurology Authors: Yi Li, Henry Rusinek, Tracy Butler, Lidia Glodzik, Elizabeth Pirraglia, John Babich, P. David Mozley, Sadek Nehmeh, Silky Pahlajani, Xiuyuan Wang, Emily B. Tanzi, Liangdong Zhou, Sara Strauss, Roxana O. Carare, Neil Theise, Nobuyuki Okamura & hellip; Tags: Research Source Type: research
Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Hydrocephalus (increased ventricular size due to CSF accumulation) is a common finding in human ciliopathies and in mouse models with genetic depletion of the multiciliated cell (MCC) cilia machinery. However,... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 5, 2022 Category: Neurology Authors: Yuechuan Xue, Zachary Gursky, Brittany Monte, Sunil Koundal, Xiaodan Liu, Hedok Lee, Tatyana V. Michurina, Kennelia A. Mellanson, Lucy Zhao, Alice Nemajerova, Kristopher T. Kahle, Ken-Ichi Takemaru, Grigori Enikolopov, Natalia I. Peunova and Helene Benven Tags: Research Source Type: research
Brain barriers virtual: an interim solution or future opportunity?
Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international conferences exist that allow res... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 1, 2022 Category: Neurology Authors: Brianna M. Holder, Shaina E. Tolan, Kaleb K. Heinrich, Kaitlin C. Miller, Natalie Hudson, Geetika Nehra, Michelle E. Pizzo, Steffen E. Storck, William F. Elmquist, Britta Engelhardt, Irena Loryan, Michal Toborek, Bjoern Bauer, Anika M. S. Hartz and Brando Tags: Research Source Type: research
The neurovascular unit in leukodystrophies: towards solving the puzzle
The neurovascular unit (NVU) is a highly organized multicellular system localized in the brain, formed by neuronal, glial (astrocytes, oligodendrocytes, and microglia) and vascular (endothelial cells and peric... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 28, 2022 Category: Neurology Authors: Parand Zarekiani, Henrique Nogueira Pinto, Elly M. Hol, Marianna Bugiani and Helga E. de Vries Tags: Review Source Type: research
Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter
Hydrocephalus is a neurological disease with an incidence of 80 –125 per 100,000 births in the United States. Neuropathology comprises ventriculomegaly, periventricular white matter (PVWM) alterations, inflamma... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 22, 2022 Category: Neurology Authors: Maria Garcia-Bonilla, Leandro Castaneyra-Ruiz, Sarah Zwick, Michael Talcott, Ayodamola Otun, Albert M. Isaacs, Diego M. Morales, David D. Limbrick Jr. and James P. McAllister II Tags: Research Source Type: research
Blood –brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells
In severe acute pancreatitis (AP) the CNS is affected manifesting in neurological symptoms. Earlier research from our laboratory showed blood –brain barrier (BBB) permeability elevation in a taurocholate-induce... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 17, 2022 Category: Neurology Authors: Fruzsina R. Walter, Andr ás Harazin, Andrea E. Tóth, Szilvia Veszelka, Ana R. Santa-Maria, Lilla Barna, András Kincses, György Biczó, Zsolt Balla, Balázs Kui, József Maléth, László Cervenak, Vilmos Tubak, Ágnes Kittel, Zoltán Rakonczay Jr and Tags: Research Source Type: research
Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus
Lumbar punctures are a common examination in the work-up of patients with idiopathic normal pressure hydrocephalus (iNPH) and cerebrospinal fluid (CSF) biomarkers should therefore be available for use in selec... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 14, 2022 Category: Neurology Authors: Madelene Braun, Caroline Bjurnemark, Woosung Seo, Eva Freyhult, Dag Nyholm, Valter Niemel ä, Kaj Blennow, Henrik Zetterberg, David Fällmar, Kim Kultima and Johan Virhammar Tags: Research Source Type: research
