Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors
The growth of malignant tumors is influenced by their microenvironment. Glioblastoma, an aggressive primary brain tumor, may have cysts containing fluid that represents the tumor microenvironment. The aim of t... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 4, 2022 Category: Neurology Authors: Daniel Dahlberg, Jutta Rummel, Sonia Distante, Gustavo Antonio De Souza, Maria Ekman Stensland, Espen Mariussen, Helge Rootwelt, Øyvind Voie and Bjørnar Hassel Tags: Research Source Type: research
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study
Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide the opportunity to identify potential genetic causes... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2022 Category: Neurology Authors: Hanbing Xu, Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Kaito Kawamura, Chihiro Akiba, Chihiro Kamohara, Koichiro Sakamoto, Kostadin Karagiozov, Eri Nakamura, Nobuhiro Tada, Hajime Arai and Akihide Kondo Tags: Research Source Type: research
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier
Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cel... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2022 Category: Neurology Authors: Yanyu Li, Chunchun Wang, Liang Zhang, Bing Chen, Yuqian Mo and Jingjing Zhang Tags: Research Source Type: research
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses
Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). ECs are able to detect SS and consequently adapt their phenotyp... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2022 Category: Neurology Authors: Nina Choublier, Meryam Taghi, Marie-Claude Menet, Morgane Le Gall, Johanna Bruce, Philippe Chafey, Fran çois Guillonneau, Amélie Moreau, Claire Denizot, Yannick Parmentier, Samir Nakib, Didier Borderie, Haniaa Bouzinba-Segard, Pierre-Olivier Couraud, Sa Tags: Research Source Type: research
Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF
Guanidinoacetate (GAA) induces epileptogenesis and neurotoxicity in the brain. As epileptic animal models have been reported to show elevated cerebral GAA levels, the processing mechanism of GAA in the brain i... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2022 Category: Neurology Authors: Ryuta Jomura, Shin-ichi Akanuma, Yoshiyuki Kubo, Masanori Tachikawa and Ken-ichi Hosoya Tags: Research Source Type: research
Effects of fasudil on blood –brain barrier integrity
Cerebral infarction accounts for 85% of all stroke cases. Even in an era of rapid and effective recanalization using an intravascular approach, the majority of patients have poor functional outcomes. Thus, the... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 3, 2022 Category: Neurology Authors: Kei Sato, Shinsuke Nakagawa, Yoichi Morofuji, Yuki Matsunaga, Takashi Fujimoto, Daisuke Watanabe, Tsuyoshi Izumo, Masami Niwa, Fruzsina R. Walter, Judit P. Vigh, Ana Raquel Santa-Maria, Maria A. Deli and Takayuki Matsuo Tags: Research Source Type: research
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies
Human blood brain barrier (BBB) models derived from induced pluripotent stem cells (iPSCs) have become an important tool for the discovery and preclinical evaluation of central nervous system (CNS) targeting c... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 1, 2022 Category: Neurology Authors: Jez Huang, Ying Betty Li, Claudie Charlebois, Tina Nguyen, Ziying Liu, Darin Bloemberg, Ahmed Zafer, Ewa Baumann, Caroline Sodja, Sonia Leclerc, Gwen Fewell, Qing Liu, Balabhaskar Prabhakarpandian, Scott McComb, Danica B. Stanimirovic and Anna Jezierski Tags: Brief Report Source Type: research
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers
Parkinson ’s disease is mainly caused by aggregation of α-synuclein (α-syn) in the brain. Exchange of α-syn between the brain and peripheral tissues could have important pathophysiological and therapeutic impli... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 30, 2022 Category: Neurology Authors: Parvez Alam, Mikkel R. Holst, Line Lauritsen, Janni Nielsen, Simone S. E. Nielsen, Poul Henning Jensen, Jonathan R. Brewer, Daniel E. Otzen and Morten S. Nielsen Tags: Research Source Type: research
Experimental approaches for manipulating choroid plexus epithelial cells
Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary source and regulator of... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 26, 2022 Category: Neurology Authors: Ahram Jang and Maria K. Lehtinen Tags: Review Source Type: research
White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery
White matter changes (WMC) on brain imaging can be classified as deep white matter hyperintensities (DWMH) or periventricular hyperintensities (PVH) and are frequently seen in patients with idiopathic normal p... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 23, 2022 Category: Neurology Authors: Carl Sn öbohm, Filip Malmberg, Eva Freyhult, Kim Kultima, David Fällmar and Johan Virhammar Tags: Research Source Type: research
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model
The movement of fluid into, through, and out of the brain plays an important role in clearing metabolic waste. However, there is controversy regarding the mechanisms driving fluid movement in the fluid-filled ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 15, 2022 Category: Neurology Authors: Ravi Teja Kedarasetti, Patrick J. Drew and Francesco Costanzo Tags: Research Source Type: research
Effects of acute and chronic oxidative stress on the blood –brain barrier in 2D and 3D in vitro models
Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and is derived from perturbations to normal cell processes by aging or environmental factors such as UV exposure and air ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 12, 2022 Category: Neurology Authors: Tracy D. Chung, Raleigh M. Linville, Zhaobin Guo, Robert Ye, Ria Jha, Gabrielle N. Grifno and Peter C. Searson Tags: Research Source Type: research
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B
Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with si... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 11, 2022 Category: Neurology Authors: Robert Murcko, Nicola Marchi, Damian Bailey and Damir Janigro Tags: Research Source Type: research
A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice
Cerebrospinal fluid (CSF) provides a close representation of pathophysiological changes occurring in the central nervous system (CNS); therefore, it has been employed in pathogenesis research and biomarker dev... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 3, 2022 Category: Neurology Authors: Tsuneo Nakajima, Shuko Takeda, Yuki Ito, Akane Oyama, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Hideo Shimizu, Munehisa Shimamura, Hiromi Rakugi and Ryuichi Morishita Tags: Research Source Type: research
Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid
Clearance of protein waste products from the brain is accomplished by a combination of advection and diffusion in cerebrospinal fluid (CSF) and interstitial fluid (ISF). In the glymphatic model, there is a flo... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 13, 2022 Category: Neurology Authors: John H. Thomas Tags: Research Source Type: research
