Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production
Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH occur in obese women of childbearing age, thou... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 16, 2023 Category: Neurology Authors: Jonathan H. Wardman, Mette N. Jensen, S øren N. Andreassen, Bjarne Styrishave, Jens E. Wilhjelm, Alexandra J. Sinclair and Nanna MacAulay Tags: Research Source Type: research
Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1
Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles i... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 16, 2023 Category: Neurology Authors: Ryann M. Fame, Huixin Xu, Aja Pragana and Maria Lehtinen Tags: Brief Report Source Type: research
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain
Despite recent attention, pathways and mechanisms of fluid transposition in the brain are still a matter of intense discussion and driving forces underlying waste clearance in the brain remain elusive. Consens... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 14, 2023 Category: Neurology Authors: Martin Segeroth, Lydia Wachsmuth, Mathias Gagel, Franziska Albers, Andreas Hess and Cornelius Faber Tags: Research Source Type: research
Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus
Neonatal hydrocephalus is a congenital abnormality resulting in an inflammatory response and microglial cell activation both clinically and in animal models. Previously, we reported a mutation in a motile cili... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 9, 2023 Category: Neurology Authors: Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano and June Goto Tags: Research Source Type: research
Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance
A glymphatic system has been proposed that comprises flow that enters along cerebral paraarterial channels between the artery wall and the surrounding glial layer, continues through the parenchyma, and then ex... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 8, 2023 Category: Neurology Authors: M. Keith Sharp Tags: Research Source Type: research
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus
Idiopathic Normal pressure hydrocephalus (iNPH) is a form of adult hydrocephalus that is clinically characterized by progressive gait impairment, cognitive dysfunction, and urinary incontinence. The current st... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 5, 2023 Category: Neurology Authors: Sophia Weiner, Antti Junkkari, Mathias Sauer, Antti Luikku, Tuomas Rauramaa, Tarja Kokkola, Sanna-Kaisa Herukka, Kaj Blennow, Henrik Zetterberg, Ville Leinonen and Johan Gobom Tags: Research Source Type: research
The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis
The choroid plexus (ChP) has been suggested as an alternative central nervous system (CNS) entry site for CCR6+ Th17 cells during the initiation of experimental autoimmune encephalomyelitis (EAE), an animal model... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 1, 2023 Category: Neurology Authors: Ivana Lazarevic, Sasha Soldati, Josephine A. Mapunda, Henriette Rudolph, Maria Rosito, Alex Cardoso de Oliveira, Gaby Enzmann, Hideaki Nishihara, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten and Britta Engelhardt Tags: Research Source Type: research
Retirement of Dr. Hazel Jones as Co-Editor-in-Chief of Fluids and Barriers of the CNS. Dr. Mark Hamilton becomes Co-Editor-in-Chief
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 29, 2023 Category: Neurology Authors: Richard F. Keep and Lester R. Drewes Tags: Editorial Source Type: research
Mouse embryonic stem cell-derived blood –brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis
Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics. Stem cell derived BBB models have recently demonstrated a subst... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 26, 2023 Category: Neurology Authors: Anna Jezierski, Jez Huang, Arsalan S. Haqqani, Julie Haukenfrers, Ziying Liu, Ewa Baumann, Caroline Sodja, Claudie Charlebois, Christie E. Delaney, Alexandra T. Star, Qing Liu and Danica B. Stanimirovic Tags: Research Source Type: research
Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI
In this study, we propose a new... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 26, 2023 Category: Neurology Authors: Jun-Hee Kim, Roh-Eul Yoo, Seung Hong Choi and Sung-Hong Park Tags: Research Source Type: research
Glucocorticoids modify intracranial pressure in freely moving rats
Glucocorticoids (GCs) are widely prescribed for a variety of inflammatory diseases, but they are also used to treat raised intracranial pressure (ICP) caused by trauma or oedema. However, it is unclear if GCs ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 25, 2023 Category: Neurology Authors: Connar Stanley James Westgate, Ida Marchen Egerod Israelsen, Christina Kamp-Jensen, Rigmor H øjland Jensen and Sajedeh Eftekhari Tags: Research Source Type: research
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Transferrin receptor 1 (TfR1) mediated brain delivery of antibodies could become important for increasing the efficacy of emerging immunotherapies in Alzheimer's disease (AD). However, age, dose, binding to Tf... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 11, 2023 Category: Neurology Authors: Rebecca Faresj ö, Dag Sehlin and Stina Syvänen Tags: Research Source Type: research
Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice
The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity was compromised due to subsequent brain injur... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 10, 2023 Category: Neurology Authors: Ling Gao, Li Peng, Prativa Sherchan, Hong Tang, Yu Liu, Jie Xiao, Hui Shi, Yujie Luo, Jiping Tang, John H. Zhang and Ying Xia Tags: Research Source Type: research
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats
Lead (Pb) is a known environmental risk factor in the etiology of Alzheimer ’s disease (AD). The existing reports suggest that Pb exposure increases beta-amyloid (Aβ) levels in brain tissues and cerebrospinal f... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - May 1, 2023 Category: Neurology Authors: Luke L. Liu, Xiaoli Shen, Huiying Gu, Gang Zhao, Yansheng Du and Wei Zheng Tags: Research Source Type: research
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17
Blue light is part of the natural light spectrum that emits high energy. Currently, people are frequently exposed to blue light from 3C devices, resulting in a growing incidence of retinopathy. The retinal vas... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - April 24, 2023 Category: Neurology Authors: Yen-Ju Chan, George Hsiao, Wang-Nok Wan, Tsung-Min Yang, Chi-Hao Tsai, Jaw-Jou Kang, Yu-Cheng Lee, Te-Chao Fang, Yu-Wen Cheng and Ching-Hao Li Tags: Research Source Type: research
