Deep learning segmentation of peri-sinus structures from structural magnetic resonance imaging: validation and normative ranges across the adult lifespan
Peri-sinus structures such as arachnoid granulations (AG) and the parasagittal dural (PSD) space have gained much recent attention as sites of cerebral spinal fluid (CSF) egress and neuroimmune surveillance. N... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 13, 2024 Category: Neurology Authors: Kilian Hett, Colin D. McKnight, Melanie Leguizamon, Jennifer S. Lindsey, Jarrod J. Eisma, Jason Elenberger, Adam J. Stark, Alexander K. Song, Megan Aumann, Ciaran M. Considine, Daniel O. Claassen and Manus J. Donahue Tags: Research Source Type: research

Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment. This is, among others, driven by a poor understanding of the ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 8, 2024 Category: Neurology Authors: Yang Hu, Milda Girdenyt é, Lieke Roest, Iida Liukkonen, Maria Siskou, Frida Bällgren, Margareta Hammarlund-Udenaes and Irena Loryan Tags: Research Source Type: research

Abstracts from Hydrocephalus 2023 —the fifteenth meeting of the Hydrocephalus Society
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 2, 2024 Category: Neurology Tags: Meeting abstracts Source Type: research

Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature
Inside the incompressible cranium, the volume of cerebrospinal fluid is directly linked to blood volume: a change in either will induce a compensatory change in the other. Vasodilatory lowering of blood pressu... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 26, 2024 Category: Neurology Authors: Jari Jukkola, Mika Kaakinen, Abhishek Singh, Sadegh Moradi, Hany Ferdinando, Teemu Myllyl ä, Vesa Kiviniemi and Lauri Eklund Tags: Research Source Type: research

CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension
Idiopathic intracranial hypertension (IIH) is a syndrome exhibiting elevated intracranial pressure (ICP), visual disturbances, and severe headache. IIH primarily affects young obese women, though it can occur ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 25, 2024 Category: Neurology Authors: Jonathan H. Wardman, S øren Norge Andreassen, Trine L. Toft-Bertelsen, Mette Nyholm Jensen, Jens E. Wilhjelm, Bjarne Styrishave, Steffen Hamann, Steffen Heegaard, Alexandra J. Sinclair and Nanna MacAulay Tags: Research Source Type: research

Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo Kp,uu,brain estimates are the gold standard for investigating brain drug di... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 25, 2024 Category: Neurology Authors: Kristine Langthaler, Christopher R. Jones, Lasse Saaby, Christoffer Bundgaard and Birger Brodin Tags: Research Source Type: research

ChOP-CT: quantitative morphometrical analysis of the Hindbrain Choroid Plexus by X-ray micro-computed tomography
The Hindbrain Choroid Plexus is a complex, cerebrospinal fluid-secreting tissue that projects into the 4th vertebrate brain ventricle. Despite its irreplaceability in the development and homeostasis of the ent... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 24, 2024 Category: Neurology Authors: Vikt ória Parobková, Petra Kompaníková, Jakub Lázňovský, Michaela Kavková, Marek Hampl, Marcela Buchtová, Tomáš Zikmund, Jozef Kaiser and Vítězslav Bryja Tags: Research Source Type: research

Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/ β-catenin axis
Blood brain barrier (BBB) breakdown is one of the key mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Astrocytes interact with endothelial and regulate BBB integrity via paracrin... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 19, 2024 Category: Neurology Authors: Ying Hou, Ye Xie, Xiaoxuan Liu, Yushan Chen, Fangfang Zhou and Binbin Yang Tags: Research Source Type: research

Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats
The brain extracellular fluid (ECF), composed of secreted neurotransmitters, metabolites, peptides, and proteins, may reflect brain processes. Analysis of brain ECF may provide new potential markers for synapt... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 11, 2024 Category: Neurology Authors: Vanda Tukacs, D ániel Mittli, Éva Hunyadi-Gulyás, Zsuzsanna Darula, Gábor Juhász, József Kardos and Katalin Adrienna Kékesi Tags: Research Source Type: research

Hydraulic resistance of three-dimensional pial perivascular spaces in the brain
Perivascular spaces (PVSs) carry cerebrospinal fluid (CSF) around the brain, facilitating healthy waste clearance. Measuring those flows in vivo is difficult, and often impossible, because PVSs are small, so a... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 11, 2024 Category: Neurology Authors: Kimberly A. S. Boster, Jiatong Sun, Jessica K. Shang, Douglas H. Kelley and John H. Thomas Tags: Research Source Type: research

Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier
Appropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of the brain to achieve HI... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 10, 2024 Category: Neurology Authors: Rodnie Col ón Ortiz, Stephen Knerler, Lisa B. Fridman, Alicia Mercado, Amira-Storm Price, Jose J. Rosado-Franco, Hannah Wilkins, Bianca R. Flores, Benjamin C. Orsburn and Dionna W. Williams Tags: Research Source Type: research

Postnatal meningeal CSF transport is primarily mediated by the arachnoid and pia maters and is not altered after intraventricular hemorrhage-posthemorrhagic hydrocephalus
CSF has long been accepted to circulate throughout the subarachnoid space, which lies between the arachnoid and pia maters of the meninges. How the CSF interacts with the cellular components of the developing ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 8, 2024 Category: Neurology Authors: Shelei Pan, Joshua P. Koleske, Gretchen M. Koller, Grace L. Halupnik, Abdul-Haq O. Alli, Shriya Koneru, Dakota DeFreitas, Sruthi Ramagiri and Jennifer M. Strahle Tags: Research Source Type: research

Blood –brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Many neuroscientists use the term Blood –Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothe... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 5, 2024 Category: Neurology Authors: Jerome Badaut, Jean-Fran çois Ghersi-Egea, Robert G. Thorne and Jan Pieter Konsman Tags: Review Source Type: research

Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice
It has been proposed that cerebrospinal fluid (CSF) can enter and leave the retina and optic nerve along perivascular spaces surrounding the central retinal vessels as part of an aquaporin-4 (AQP4) dependent o... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 4, 2024 Category: Neurology Authors: Xiao J. Tong, Gokhan Akdemir, Meetu Wadhwa, Alan S. Verkman and Alex J. Smith Tags: Research Source Type: research

Sex, hormones and cerebrovascular function: from development to disorder
Proper cerebrovascular development and neurogliovascular unit assembly are essential for brain growth and function throughout life, ensuring the continuous supply of nutrients and oxygen. This involves crucial... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 4, 2024 Category: Neurology Authors: Adeline Collignon, Laurence Dion-Albert, Caroline M énard and Vanessa Coelho-Santos Tags: Review Source Type: research