Ventricular volume in relation to lumbar CSF levels of amyloid- β 1–42, tau and phosphorylated tau in iNPH, is there a dilution effect?
Levels of the biomarkers amyloid- β 1–42 (Aβ42), tau and phosphorylated tau (p-tau) are decreased in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH). The mechanism... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 17, 2022 Category: Neurology Authors: Simon Lid én, Dan Farahmand and Katarina Laurell Tags: Research Source Type: research
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood –brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis
Traumatic brain injury (TBI) provokes secondary pathological damage, such as damage to the blood –brain barrier (BBB), ischaemia and inflammation. Major facilitator superfamily domain-containing 2a (Mfsd2a) has... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 11, 2022 Category: Neurology Authors: Yuan Zhang, Lin Wang, Qiuling Pan, Xiaomin Yang, Yunchuan Cao, Jin Yan, Yingwen Wang, Yihao Tao, Runjin Fan, Xiaochuan Sun and Lin Li Tags: Research Source Type: research
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone
Glioblastoma (GBM) is the most aggressive and common type of primary brain tumor in adults. Tumor location plays a role in patient prognosis, with tumors proximal to the lateral ventricles (LVs) presenting wit... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 11, 2022 Category: Neurology Authors: Emily S. Norton, Lauren A. Whaley, Mar ía José Ulloa-Navas, Patricia García-Tárraga, Kayleah M. Meneses, Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Alfredo Quiñones-Hinojosa, José Manuel García-Verdugo and Hugo Guerrero-Cázares Tags: Research Source Type: research
Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders
Quantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases. Possibly, variability in cerebrospinal fluid clearance may affect the underlyi... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 1, 2022 Category: Neurology Authors: Markus Herberg Hovd, Espen Mariussen, Hilde Uggerud, Aslan Lashkarivand, Hege Christensen, Geir Ringstad and Per Kristian Eide Tags: Research Source Type: research
Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method
Cerebral amyloid angiopathy (CAA) occurs in 80% of patients with Alzheimer ’s disease (AD) and is mainly caused by the abnormal deposition of Aβ in the walls of cerebral blood vessels. Cerebrovascular molecular... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 1, 2022 Category: Neurology Authors: Takumi Handa, Hayate Sasaki, Masaki Takao, Mitsutoshi Tano and Yasuo Uchida Tags: Research Source Type: research
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington ’s disease
Huntington ’s disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive a... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 30, 2022 Category: Neurology Authors: Raleigh M. Linville, Ren ée F. Nerenberg, Gabrielle Grifno, Diego Arevalo, Zhaobin Guo and Peter C. Searson Tags: Research Source Type: research
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus
Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is routinely relieved with neurosurgical approaches, since effective and targete... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 29, 2022 Category: Neurology Authors: Dagne Barbuskaite, Eva K. Oernbo, Jonathan H. Wardman, Trine L. Toft-Bertelsen, Eller Conti, S øren N. Andreassen, Niklas J. Gerkau, Christine R. Rose and Nanna MacAulay Tags: Research Source Type: research
Cerebrospinal fluid osmolality cannot predict development or surgical outcome of idiopathic normal pressure hydrocephalus
The etiology of idiopathic normal pressure hydrocephalus (iNPH) is currently unknown. With no visible obstructions, altered cerebrospinal fluid (CSF) dynamics may explain the accumulation of ventricular fluid.... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 27, 2022 Category: Neurology Authors: Eva Kjer Oernbo, Annette Buur Steffensen, Hanne Gredal, Helle Harding Poulsen, Nina Rostgaard, Cecilie Holm Rasmussen, Marlene M øller-Nissen, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Marianne Juhler and Nanna MacAulay Tags: Research Source Type: research
Gait apraxia evaluation in normal pressure hydrocephalus using inertial sensors. Clinical correlates, ventriculoperitoneal shunt outcomes, and tap-test predictive capacity
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition with gait apraxia signs from its early manifestation. Ventriculoperitoneal shunt (VPS) is a surgical procedure available for treatmen... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 23, 2022 Category: Neurology Authors: Alberto Ferrari, David Milletti, Pierpaolo Palumbo, Giulia Giannini, Sabina Cevoli, Elena Magelli, Luca Albini-Riccioli, Paolo Mantovani, Pietro Cortelli, Lorenzo Chiari and Giorgio Palandri Tags: Research Source Type: research
The impact of genetic manipulation of laminin and integrins at the blood –brain barrier
Blood vessels in the central nervous system (CNS) are unique in having high electrical resistance and low permeability, which creates a selective barrier protecting sensitive neural cells within the CNS from p... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 11, 2022 Category: Neurology Authors: Sebok K. Halder, Arjun Sapkota and Richard Milner Tags: Review Source Type: research
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein
The brain requires iron for a number of processes, including energy production. Inadequate or excessive amounts of iron can be detrimental and lead to a number of neurological disorders. As such, regulation of... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 10, 2022 Category: Neurology Authors: Stephanie L. Baringer, Elizabeth B. Neely, Kondaiah Palsa, Ian A. Simpson and James R. Connor Tags: Research Source Type: research
Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity
This editorial highlights advances in brain barrier and brain fluid research in 2021. It covers research on components of the blood –brain barrier, neurovascular unit and brain fluid systems; how brain barriers... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 9, 2022 Category: Neurology Authors: Richard F. Keep, Hazel C. Jones and Lester R. Drewes Tags: Editorial Source Type: research
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping
Knowledge of the entry receptors responsible for SARS-CoV-2 is key to understand the neural transmission and pathogenesis of COVID-19 characterized by a neuroinflammatory scenario. Understanding the brain dist... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 7, 2022 Category: Neurology Authors: Yong Zhang, Sabrina Rahman Archie, Yashwardhan Ghanwatkar, Sejal Sharma, Saeideh Nozohouri, Elizabeth Burks, Alexander Mdzinarishvili, Zijuan Liu and Thomas J. Abbruscato Tags: Research Source Type: research
Vascular network expansion, integrity of blood –brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat
Severe neonatal jaundice resulting from elevated levels of unconjugated bilirubin in the blood induces dramatic neurological impairment. Central oxidative stress and an inflammatory response have been associat... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 7, 2022 Category: Neurology Authors: Sandrine Blondel, Nathalie Strazielle, Amel Amara, Rainui Guy, Christine Bain, Alix Rose, Laurent Guibaud, Claudio Tiribelli, Silvia Gazzin and Jean-Fran çois Ghersi-Egea Tags: Research Source Type: research
Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus
Dysregulation of brain fluid homeostasis associates with brain pathologies in which fluid accumulation leads to elevated intracranial pressure. Surgical intervention remains standard care, since specific and e... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - June 4, 2022 Category: Neurology Authors: S øren N. Andreassen, Trine L. Toft-Bertelsen, Jonathan H. Wardman, René Villadsen and Nanna MacAulay Tags: Research Source Type: research
