Proteomic interrogation of the meninges reveals the molecular identities of structural components and regional distinctions along the CNS axis
The meninges surround the brain and spinal cord, affording physical protection while also serving as a niche of neuroimmune activity. Though possessing stromal qualities, its complex cellular and extracellular... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 19, 2023 Category: Neurology Authors: Elise Santorella, Jeremy L. Balsbaugh, Shujun Ge, Parisa Saboori, David Baker and Joel S. Pachter Tags: Research Source Type: research
Occludin: a gatekeeper of brain Infection by HIV-1
Compromised structure and function of the blood-brain barrier (BBB) is one of the pathological hallmarks of brain infection by HIV-1. BBB damage during HIV-1 infection has been associated with modified express... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 16, 2023 Category: Neurology Authors: Silvia Torices, Leah Daire, Sierra Simon, Oandy Naranjo, Luisa Mendoza, Timea Teglas, Nikolai Fattakhov, Daniel Adesse and Michal Toborek Tags: Review Source Type: research
Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
Neuroinflammatory processes have been suggested to play a role in the pathophysiology of neurodegenerative diseases and post-hemorrhagic hydrocephalus, but have rarely been investigated in patients with idiopa... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 13, 2023 Category: Neurology Authors: Madelene Braun, Gustaf Bostr öm, Martin Ingelsson, Lena Kilander, Malin Löwenmark, Dag Nyholm, Joachim Burman, Valter Niemelä, Eva Freyhult, Kim Kultima and Johan Virhammar Tags: Research Source Type: research
In vitro investigation of the effect of proinflammatory cytokines on mouse choroid plexus membrane transporters Ncbe and NKCC1
Intraventricular hemorrhage is a potentially life-threatening condition. Approximately 20% of patients develop posthemorrhagic hydrocephalus with increased ventricular volume and intracranial pressure. Hydroce... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 12, 2023 Category: Neurology Authors: Laura Øllegaard Johnsen, Kathrine Abildskov Friis and Helle Hasager Damkier Tags: Research Source Type: research
Proteasome inhibition protects blood –brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model
Loss of P-glycoprotein (P-gp) at the blood –brain barrier contributes to amyloid-β (Aβ) brain accumulation in Alzheimer’s disease (AD). Using transgenic human amyloid precursor protein (hAPP)-overexpressing mic... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 6, 2023 Category: Neurology Authors: Milica Vulin, Yu Zhong, Bryan J. Maloney, Bj örn Bauer and Anika M. S. Hartz Tags: Research Source Type: research
Transient intracranial pressure elevations (B waves) are associated with sleep apnea
Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used to define pathological conditions and determine indications for ICP-reducing treatment. We recently sho... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 2, 2023 Category: Neurology Authors: Casper Schwartz Riedel, Isabel Martinez-Tejada, Morten Andresen, Jens E. Wilhjelm, Poul Jennum and Marianne Juhler Tags: Research Source Type: research
Blood-spinal cord barrier disruption in degenerative cervical myelopathy
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord dysfunction in the aging population. Significant neurological deficits may result from a delayed diagnosis as well as inadequat... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 25, 2023 Category: Neurology Authors: Hyun Woo Kim, Hu Yong and Graham Ka Hon Shea Tags: Review Source Type: research
BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains
Pharmacological treatment of CNS diseases is limited due to the presence of the blood-brain barrier (BBB). Recent years showed significant advancement in the field of CNS drug delivery enablers, with technolog... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 22, 2023 Category: Neurology Authors: Itzik Cooper, David Last, Orly Ravid, Daniel Rand, Erez Matsree, Liora Omesi, Chen Shemesh, Meir Liberman, Leor Zach, Orit Furman, Dianne Daniels, Sigal Liraz-Zaltsman, Yael Mardor and Shirley Sharabi Tags: Research Source Type: research
Proteomic alterations in the brain and blood –brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
This study aimed to investigate the relationship between BBB alterations and AD progressio... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 14, 2023 Category: Neurology Authors: Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido and Sumio Ohtsuki Tags: Research Source Type: research
Cerebral arterial flow dynamics during systole and diastole phases in young and older healthy adults
Since arterial flow is the leading actor in neuro-fluids flow dynamics, it might be interesting to assess whether it is meaningful to study the arterial flow waveform in more detail and whether this provides n... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 13, 2023 Category: Neurology Authors: Kimi Piedad Owashi, Cyrille Capel and Olivier Bal édent Tags: Research Source Type: research
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody
The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 24, 2023 Category: Neurology Authors: Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim and David L. Brody Tags: Research Source Type: research
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?
The literature regarding the global cerebral blood flow (CBF) in idiopathic intracranial hypertension (IIH) is divergent leading to skepticism about the significance of blood flow to the disease ’s underlying p... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 23, 2023 Category: Neurology Authors: Grant A Bateman Tags: Review Source Type: research
Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models
Hydrocephalus is a pathological accumulation of cerebrospinal fluid (CSF), leading to ventriculomegaly. Hydrocephalus may be primary or secondary to traumatic brain injury, infection, or intracranial hemorrhag... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 18, 2023 Category: Neurology Authors: Alexandra Hochstetler, Hillary Smith, Makenna Reed, Louise Hulme, Paul Territo, Amanda Bedwell, Scott Persohn, Nicola Perrotti, Lucia D ’Antona, Francesca Musumeci, Silvia Schenone and Bonnie L. Blazer-Yost Tags: Research Source Type: research
Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation
Whether you are reading, running or sleeping, your brain and its fluid environment continuously interacts to distribute nutrients and clear metabolic waste. Yet, the precise mechanisms for solute transport wit... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 18, 2023 Category: Neurology Authors: Vegard Vinje, Bastian Zapf, Geir Ringstad, Per Kristian Eide, Marie E. Rognes and Kent-Andre Mardal Tags: Research Source Type: research
Relationship between brain iron dynamics and blood-brain barrier function during childhood: a quantitative magnetic resonance imaging study
Mounting evidence suggests that the blood-brain barrier (BBB) plays an important role in the regulation of brain iron homeostasis in normal brain development, but these imaging profiles remain to be elucidated... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 17, 2023 Category: Neurology Authors: Yuto Uchida, Hirohito Kan, Gen Furukawa, Kengo Onda, Keita Sakurai, Koji Takada, Noriyuki Matsukawa and Kenichi Oishi Tags: Research Source Type: research
