The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
Idiopathic normal pressure hydrocephalus (iNPH) is a multifactorial disease presenting with a classical symptom triad of cognitive decline, gait disturbance and urinary incontinence. The symptoms can be allevi... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 8, 2022 Category: Neurology Authors: Jani Sirkka, Laura S äisänen, Petro Julkunen, Mervi Könönen, Elisa Kallioniemi, Ville Leinonen and Nils Danner Tags: Research Source Type: research
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer ´s disease and type two diabetes
While aging is the main risk factor for Alzheimer ´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have d... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 7, 2022 Category: Neurology Authors: Maria Vargas-Soria, Juan Jose Ramos-Rodriguez, Angel del Marco, Carmen Hierro-Bujalance, Maria Jose Carranza-Naval, Maria Calvo-Rodriguez, Susanne J. van Veluw, Alan W. Stitt, Rafael Sim ó, Brian J. Bacskai, Carmen Infante-Garcia and Monica Garcia-Alloza Tags: Research Source Type: research
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood –brain barrier microvessels
The blood –brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport,... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 5, 2022 Category: Neurology Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Ren ée F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson Tags: Research Source Type: research
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension
This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracran... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 1, 2022 Category: Neurology Authors: James L Mitchell, Rebecca Buckham, Hannah Lyons, Jessica K Walker, Andreas Yiangou, Matilde Sassani, Mark Thaller, Olivia Grech, Zerin Alimajstorovic, Marianne Julher, Georgios Tsermoulas, Kristian Brock, Susan P Mollan and Alexandra J Sinclair Tags: Research Source Type: research
Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
The unique environment of the brain and retina is tightly regulated by blood –brain barrier and the blood-retinal barrier, respectively, to ensure proper neuronal function. Endothelial cells within these tissue... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 1, 2022 Category: Neurology Authors: Andreia Goncalves and David A. Antonetti Tags: Review Source Type: research
Correction to: The choroid plexus: A door between the blood and the brain for tissue-type plasminogen activator
(Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 1, 2022 Category: Neurology Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lazarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien and Carine Ali Tags: Correction Source Type: research
Human intracranial pulsatility during the cardiac cycle: a computational modelling framework
Today ’s availability of medical imaging and computational resources set the scene for high-fidelity computational modelling of brain biomechanics. The brain and its environment feature a dynamic and complex in... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - November 1, 2022 Category: Neurology Authors: Marius Causemann, Vegard Vinje and Marie E. Rognes Tags: Research Source Type: research
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age
Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes h... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 28, 2022 Category: Neurology Authors: Yosuke Hidaka, Mamoru Hashimoto, Takashi Suehiro, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Kazuki Honda, Yusuke Miyagawa, Kazuhiro Yoshiura, Shuken Boku, Kazunari Ishii, Manabu Ikeda and Minoru Takebayashi Tags: Research Source Type: research
Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection
Bacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the huma... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 26, 2022 Category: Neurology Authors: Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim and Alexandra Schubert-Unkmeir Tags: Research Source Type: research
The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator
In the vascular compartment, the serine protease tissue-type plasminogen activator (tPA) promotes fibrinolysis, justifying its clinical use against vasculo-occlusive diseases. Accumulating evidence shows that ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 15, 2022 Category: Neurology Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lazarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien and Carine Ali Tags: Research Source Type: research
VHHs as tools for therapeutic protein delivery to the central nervous system
The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a b... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - October 3, 2022 Category: Neurology Authors: Yessica Wouters, Tom Jaspers, Laura Ru é, Lutgarde Serneels, Bart De Strooper and Maarten Dewilde Tags: Research Source Type: research
The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure
The composition of tissue obstructing neuroprosthetic devices is largely composed of inflammatory cells with a significant astrocyte component. In a first-of-its-kind study, we profile the astrocyte phenotypes... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 28, 2022 Category: Neurology Authors: Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob Gluski, Neena I. Marupudi, James P. McAllister II, David D. Limbrick Jr. and Carolyn A. Harris Tags: Research Source Type: research
Nuclear receptor ligand screening in an iPSC-derived in vitro blood –brain barrier model identifies new contributors to leptin transport
The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated se... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 21, 2022 Category: Neurology Authors: Yajuan Shi, Hyosung Kim, Catherine A. Hamann, Elizabeth M. Rhea, Jonathan M. Brunger and Ethan S. Lippmann Tags: Research Source Type: research
Mucopolysaccharidoses and the blood –brain barrier
Mucopolysaccharidoses comprise a set of genetic diseases marked by an enzymatic dysfunction in the degradation of glycosaminoglycans in lysosomes. There are eight clinically distinct types of mucopolysaccharid... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 19, 2022 Category: Neurology Authors: Onur Sahin, Hannah P. Thompson, Grant W. Goodman, Jun Li and Akihiko Urayama Tags: Review Source Type: research
The choroid plexus and its role in the pathogenesis of neurological infections
The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the ce... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - September 10, 2022 Category: Neurology Authors: Derick Thompson, Catherine A. Brissette and John A. Watt Tags: Review Source Type: research
