CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis
Multiple sclerosis (MS) is a complex, heterogenous disease characterized by inflammation, demyelination, and blood –brain barrier (BBB) permeability. Currently, active disease is determined by physician confirm... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 8, 2022 Category: Neurology Authors: Michael Mazzucco, William Mannheim, Samantha V. Shetty and Jennifer R. Linden Tags: Research Source Type: research
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord
Cerebrospinal fluid (CSF) circulation in the brain has garnered considerable attention in recent times. In contrast, there have been fewer studies focused on the spine, despite the expected importance of CSF c... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 8, 2022 Category: Neurology Authors: Shinuo Liu, Lynne E. Bilston, Neftali Flores Rodriguez, Courtney Wright, Simon McMullan, Robert Lloyd, Marcus A. Stoodley and Sarah J. Hemley Tags: Research Source Type: research
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer ’s brain milieu
Human induced pluripotent stem cell (hiPSC)-derived brain endothelial-like cells (iBECs) are a robust, scalable, and translatable model of the human blood –brain barrier (BBB). Prior works have shown that high ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 5, 2022 Category: Neurology Authors: Lindsey M. Williams, Takashi Fujimoto, Riley R. Weaver, Aric F. Logsdon, Kira M. Evitts, Jessica E. Young, William A. Banks and Michelle A. Erickson Tags: Research Source Type: research
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients
The relationship between cerebrospinal fluid (CSF) biomarkers and the clinical features of idiopathic normal pressure hydrocephalus (iNPH) has been inconclusive. We aimed to evaluate CSF biomarkers reflecting ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 5, 2022 Category: Neurology Authors: Heikki Lukkarinen, Anna Jeppsson, Carsten Wikkels ö, Kaj Blennow, Henrik Zetterberg, Radu Constantinescu, Anne M. Remes, Sanna-Kaisa Herukka, Mikko Hiltunen, Tuomas Rauramaa, Katarina Nägga, Ville Leinonen and Mats Tullberg Tags: Research Source Type: research
k-Shape clustering for extracting macro-patterns in intracranial pressure signals
Intracranial pressure (ICP) monitoring is a core component of neurosurgical diagnostics. With the introduction of telemetric monitoring devices in the last years, ICP monitoring has become feasible in a broade... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 5, 2022 Category: Neurology Authors: Isabel Martinez-Tejada, Casper Schwartz Riedel, Marianne Juhler, Morten Andresen and Jens E. Wilhjelm Tags: Research Source Type: research
The glymphatic hypothesis: the theory and the evidence
The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of the brain of hydrophilic solutes unable to cross the blood –brain barrier. It suggests that there is a circulation of f... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 3, 2022 Category: Neurology Authors: Stephen B. Hladky and Margery A. Barrand Tags: Review Source Type: research
Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology
Intrathecal drug delivery has a significant role in pain management and central nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in choosing specific drug doses to the... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 28, 2022 Category: Neurology Authors: Mohammadreza Khani, Goutham Kumar Reddy Burla, Lucas R. Sass, Ostin N. Arters, Tao Xing, Haiming Wu and Bryn A. Martin Tags: Research Source Type: research
Met-RANTES preserves the blood –brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice
C –C chemokine receptor type 1 (CCR1) and its endogenous ligand, CCL5, participate in the pathogenesis of neuroinflammatory diseases. However, much remains unknown regarding CCL5/CCR1 signaling in blood–brain b... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 21, 2022 Category: Neurology Authors: Jun Yan, Weilin Xu, Cameron Lenahan, Lei Huang, Umut Ocak, Jing Wen, Gaigai Li, Wei He, Chensheng Le, John H. Zhang, Ligen Mo and Jiping Tang Tags: Research Source Type: research
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
Ways to prevent disease-induced vascular modifications that accelerate brain damage remain largely elusive. Improved understanding of perivascular cell signalling could provide unparalleled insight as these ce... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 15, 2022 Category: Neurology Authors: Julia Baumann, Chih-Chieh Tsao, Shalmali Patkar, Sheng-Fu Huang, Simona Francia, Synn øve Norvoll Magnussen, Max Gassmann, Johannes Vogel, Christina Köster-Hegmann and Omolara O. Ogunshola Tags: Research Source Type: research
The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients
The aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Further... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 10, 2022 Category: Neurology Authors: Nina Sundstr öm, Johanna Rydja, Johan Virhammar, Lena Kollén, Fredrik Lundin and Mats Tullberg Tags: Research Source Type: research
Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer ’s disease related Aβ amyloidosis
Altered cerebrovascular function and accumulation of amyloid- β (Aβ) after traumatic brain injury (TBI) can contribute to chronic neuropathology and increase the risk for Alzheimer’s disease (AD). TBI due to a ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 10, 2022 Category: Neurology Authors: Alexander T. Clark, Eric E. Abrahamson, Matthew M. Harper and Milos D. Ikonomovic Tags: Research Source Type: research
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse
The blood-cerebrospinal fluid (CSF) barrier (BCSFB) is critically important to the pathophysiology of the central nervous system (CNS). However, this barrier prevents the safe transmission of beneficial drugs ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 6, 2022 Category: Neurology Authors: Yi Kung, Kuan-Yu Chen, Wei-Hao Liao, Yi-Hua Hsu, Chueh-Hung Wu, Ming-Yen Hsiao, Abel P.-H. Huang and Wen-Shiang Chen Tags: Research Source Type: research
Intercompartmental communication between the cerebrospinal and adjacent spaces during intrathecal infusions in an acute ovine in-vivo model
The treatment of hydrocephalus has been a topic of intense research ever since the first clinically successful use of a valved cerebrospinal fluid shunt 72 years ago. While ample studies elucidating different ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 4, 2022 Category: Neurology Authors: Anthony Podgor šak, Nina Eva Trimmel, Markus Florian Oertel, Sara Qvarlander, Margarete Arras, Anders Eklund, Miriam Weisskopf and Marianne Schmid Daners Tags: Research Source Type: research
Upright versus supine MRI: effects of body position on craniocervical CSF flow
Cerebrospinal fluid (CSF) circulation between the brain and spinal canal, as part of the glymphatic system, provides homeostatic support to brain functions and waste clearance. Recently, it has been observed t... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 24, 2021 Category: Neurology Authors: Marco Muccio, David Chu, Lawrence Minkoff, Neeraj Kulkarni, Brianna Damadian, Raymond V. Damadian and Yulin Ge Tags: Research Source Type: research
Biochemical profile of human infant cerebrospinal fluid in intraventricular hemorrhage and post-hemorrhagic hydrocephalus of prematurity
Intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHH) have a complex pathophysiology involving inflammatory response, ventricular zone and cell –cell junction disruption, and choroid-plexus... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - December 24, 2021 Category: Neurology Authors: Ayodamola Otun, Diego M. Morales, Maria Garcia-Bonilla, Seth Goldberg, Leandro Castaneyra-Ruiz, Yan Yan, Albert M. Isaacs, Jennifer M. Strahle, James P. McAllister II and David D. Limbrick Jr Tags: Research Source Type: research
