Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus

Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological condition of unresolved etiology characterized by a clinical triad of symptoms; gait disturbances, urinary incontinence,...
Source: Cerebrospinal Fluid Research - Category: Neurology Authors: Tags: Research Source Type: research

Related Links:

Palihapitiya-Led SPAC to Merge With Akili in $1 Billion Deal (Bloomberg): Akili Interactive, a startup that has developed a video game to help treat attention-deficit disorders in kids, has agreed to go public through a merger with one of Chamath Palihapitiya’s blank-check companies. The deal, which confirms a Bloomberg News report, values the combined entity at about $1 billion, Akili and Social Capital Suvretta Holdings Corp. I said in a statement seen by Bloomberg. It will provide as much as $412 million in gross cash proceeds, the companies said. Led by Chief Executive Officer Eddie Martucci, Akili has developed ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Attention & ADD/ADHD Brain/ Mental Health Technology & Innovation Akili Interactive attention deficit hyperactivity disorder Chamath Palihapitiya cognitive-impairments digital therapeutics EndeavorRx FDA neuropsychiatric neuropsychia Source Type: blogs
Conditions:   Female Stress Incontinence;   Stress Urinary Incontinence Intervention:   Biological: UVT Sponsor:   TBF Genie Tissulaire Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study employed secondary analysis of outcome measures data collected during the Optimal Pelvic floor muscle training for Adherence Long-term (OPAL) RCT, which compared biofeedback-mediated pelvic floor muscle training to basic pelvic floor muscle training for women with UI. The relative performance of EQ-5D-3L and ICIQ-UI SF, and EQ-5D-3L and POP-SS was assessed for concurrent validity and known-groups validity. Data for 577 women (mean age 48) were available for EQ-5D-3L/ICIQ-UI SF, and 555 women (mean age 47) for EQ-5D-3L/POP-SS. Overall, EQ-5D-3L exhibited very weak association with the ICIQ-UI SF total score, or a...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Voltage-gated sodium channel genes are an important family of human epilepsy genes. De novo missense mutations in SCN8A (encoding Nav1.6) are associated with a spectrum of clinical presentation, including multiple seizure types, movement disorders, intellectual disability, and behavioral abnormalities such as autism. Patients with SCN8A mutations are often treated with multiple antiepileptic drugs, the most common being sodium channel blockers. Cannabidiol (CBD) has been included as a component of treatment regimens for some SCN8A patients; however, to date, there are no clinical trials that have evaluated the therapeutic ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Photo credit Seth Hays Decades ago, it was fairly common to have grandparents living with family and it often worked well. It did for my family. My parents built a new house that could accommodate all the different generations and afforded some privacy for all. Grandma moved in, and the arrangement worked. My mom did not work outside the home, so there was nearly always someone home with Grandma. I was also a born caregiver and gladly did what I could to help care for both my toddler sister and my grandmother.  These days, having an aging loved one move in is still an option for some families, but it has become more c...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
TUESDAY, Jan. 25, 2022 -- Living through the pandemic has not been easy for kids, but it has really thrown off children who have attention-deficit/hyperactivity disorder (ADHD), new research warns. Though they were not more likely to catch...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Condition:   Urodynamic Stress Incontinence Intervention:   Diagnostic Test: Transperineal ultrasound Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Rev Med Interne. 2021 Jun 15:S0248-8663(21)00516-6. doi: 10.1016/j.revmed.2021.05.018. Online ahead of print.ABSTRACTFormerly called normal pressure hydrocephalus, communicating chronic hydrocephalus (CCH) is a condition affecting 0.1 to 0.5% of patients over 60years of age. The pathophysiology of this disease is poorly understood, but a defect in cerebrospinal fluid (CSF) resorption appears to be commonly defined as the cause of the neurological disorders. The last important discovery is the description of the glymphatic system and its implication in CCH and CSF resorption. Comorbidities (Alzheimer's disease, microangiopa...
Source: Revue de Medecine Interne - Category: Internal Medicine Authors: Source Type: research
More News: Brain | Hydrocephalus | Hyperactivity | Incontinence | Neurology