Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies
ConclusionsOur meta-analysis of transcriptomic data provides a powerful approach to identify sex-based differences in NAFLD. We detected differences in relevant biological functions and molecular terms between premenopausal women and men. Differences in immune responsiveness between men and premenopausal women with NAFLD suggest that women possess a more immune tolerant milieu, while men display an impaired liver regenerative response.Graphical abstract (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 25, 2021 Category: Biology Source Type: research
Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones
ConclusionGonadal steroid hormones can stimulate the progression of glioblastomas through the increase in proliferation, migration, and invasion. However, the effects mentioned above depend on the concentrations of these hormones and the receptor involved in hormone actions. Estradiol and progesterone can exert promoter or protective effects while the role of testosterone has been always associated to glioblastomas progression. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 22, 2021 Category: Biology Source Type: research
Chronic ethanol vapor exposure potentiates cardiovascular responses to acute stress in male but not in female rats
ConclusionChronic ethanol vapor exposure increased the cardiovascular reactivity to stress in male, but not in female rats. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 16, 2021 Category: Biology Source Type: research
Sex differences in fetal Doppler parameters during gestation
ConclusionsDoppler ultrasound parameters were found to be dependent on fetal sex for some vessels and not for others in healthy pregnancies. Further investigations are needed to understand the physiological mechanisms for these sex differences and the relevance for disease processes in pregnancy. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 10, 2021 Category: Biology Source Type: research
Thyroid hormone: sex-dependent role in nervous system regulation and disease
AbstractThyroid hormone (TH) regulates many functions including metabolism, cell differentiation, and nervous system development. Alteration of thyroid hormone level in the body can lead to nervous system-related problems linked to cognition, visual attention, visual processing, motor skills, language, and memory skills. TH has also been associated with neuropsychiatric disorders including schizophrenia, bipolar disorder, anxiety, and depression. Males and females display sex-specific differences in neuronal signaling. Steroid hormones including testosterone and estrogen are considered to be the prime regulators for progra...
Source: Biology of Sex Differences - March 8, 2021 Category: Biology Source Type: research
Sex differences in noise-induced hearing loss: a cross-sectional study in China
ConclusionsThis study indicates significant sex differences in NIHL. Males are at higher risk of HFHL than females despite equivalent noise exposure and age. The risk factors for NIHL might be different in males and females. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 6, 2021 Category: Biology Source Type: research
Gender-related variables for health research
ConclusionOur new instrument represents an important step toward developing more comprehensive and precise survey-based measures of gender in relation to health. Our questionnaire is designed to shed light on how specific gender-related behaviors and attitudes contribute to health and disease processes, irrespective of —or in addition to—biological sex and self-reported gender identity. Use of these gender-related variables in experimental studies, such as clinical trials, may also help us understand if gender factors play an important role as treatment-effect modifiers and would thus need to be further consid ered in ...
Source: Biology of Sex Differences - February 22, 2021 Category: Biology Source Type: research
Estrogen receptors in pain modulation: cellular signaling
AbstractSensory perception and emotional disorders are disproportionally represented in men and women and are thus thought to be modulated by different sex hormones in various conditions. Among the most important hormones perceived to affect sensory processing and transduction is estrogen. Numerous previous researchers have endeavored to demonstrate that estrogen is capable of modulating the activity of sensory neurons in peripheral and central sites in female, male, or castrated animals. However, the underlying mechanisms of its modulation of neuronal activity are somewhat unclear. In the present review, we discuss the po...
Source: Biology of Sex Differences - February 10, 2021 Category: Biology Source Type: research
Sex-dependent effects of prenatal food and protein restriction on offspring physiology in rats and mice: systematic review and meta-analyses
ConclusionsWe found little support for the hypotheses that males are more affected by food and protein restriction, or that effects are particularly severe if nutrition is reduced part-way through gestation. However, less than half of the studies tested for sex by maternal diet interactions to identify sex-dependent effects. As a result, many reported sex-specific effects may be false positives. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - February 9, 2021 Category: Biology Source Type: research
Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans
ConclusionsThis study highlights sex disparities in clinical determinants of severe outcomes in COVID-19 patients that may inform management and prevention strategies to ensure gender equity. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - February 5, 2021 Category: Biology Source Type: research
Sex differences in uterine artery Doppler during gestation in pregnancies complicated by placental dysfunction
ConclusionsThe uterine artery PI is widely used to assess uteroplacental function in clinical settings. The observation that this metric changes more rapidly in complicated pregnancies where the fetus was male highlights the importance of sex when interpreting hemodynamic markers of placental maturation. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - February 2, 2021 Category: Biology Source Type: research
Age-dependent changes of gender disparities in nasopharyngeal carcinoma survival
ConclusionsGender disparities in cancer-specific mortality for patients with NPC were age-dependent. The differences mostly cannot be explained by confounder or mediation effects. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 30, 2021 Category: Biology Source Type: research
The visceral fat area to leg muscle mass ratio is significantly associated with the risk of hyperuricemia among women: a cross-sectional study
ConclusionThe VFA-to-LMM ratio was positively associated with the risk of hyperuricemia in women after adjustment by confounders. Pre-menopausal women have a higher risk of hyperuricemia than postmenopausal women with the increase of the VFA-to-LMM ratio. In addition, the highest risk of hyperuricemia was demonstrated when both VFA and LMM were at the highest quartile. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 29, 2021 Category: Biology Source Type: research
Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis
ConclusionsMen had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor prognosis of postmenopausal women in clinical practice. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 29, 2021 Category: Biology Source Type: research
Gender score development in the Berlin Aging Study II: a retrospective approach
AbstractIn addition to biological sex, gender, defined as the sociocultural dimension of being a woman or a man, plays a central role in health. However, there are so far few approaches to quantify gender in a retrospective manner in existing study datasets. We therefore aimed to develop a methodology that can be retrospectively applied to assess gender in existing cohorts. We used baseline data from the Berlin Aging Study II (BASE-II), obtained in 2009 –2014 from 1869 participants aged 60 years and older. We identified 13 gender-related variables and used them to construct a gender score by using primary component and...
Source: Biology of Sex Differences - January 18, 2021 Category: Biology Source Type: research
