Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies

ConclusionsOur meta-analysis of transcriptomic data provides a powerful approach to identify sex-based differences in NAFLD. We detected differences in relevant biological functions and molecular terms between premenopausal women and men. Differences in immune responsiveness between men and premenopausal women with NAFLD suggest that women possess a more immune tolerant milieu, while men display an impaired liver regenerative response.Graphical abstract
Source: Biology of Sex Differences - Category: Biology Source Type: research