Correction to: Consideration of sex and gender differences in addiction medication response
(Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 13, 2022 Category: Biology Source Type: research
Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging
ConclusionsMales with HCM had favorable reverse remodeling with greater LV mass regression post-ASA than female patients. This favorable LV reverse remodeling might provide a mechanistic explanation for the survival advantage in men. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 7, 2022 Category: Biology Source Type: research
Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking
ConclusionsThese findings indicate that CS exposure worsens the progression of cardiac remodeling post-MI in male sex in a significant manner compared to female sex at least at early stages. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 7, 2022 Category: Biology Source Type: research
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms
ConclusionsSex-related differences in uterine/umbilical blood flows, placental development, and fetal O2 consumption can be linked to the differences observed in cord oxygen. The lower umbilical artery oxygen in females as a measure of systemic oxygenation signaling growth could account for their decreased birth weights, while slower development in female placentae could account for their lower placental weights, which could be differentially effected contributing to their lower birth/placental weights. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 29, 2022 Category: Biology Source Type: research
Consideration of sex and gender differences in addiction medication response
AbstractSubstance use continues to contribute to significant morbidity and mortality in the United States, for both women and men, more so than another other preventable health condition. To reduce the public health burden attributable to substances, the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism have identified that medication development for substance use disorder is a high priority research area. Furthermore, both Institutes have stated that research on sex and gender differences in substance use medication development is a critical area. The purpose of the current narrat...
Source: Biology of Sex Differences - June 27, 2022 Category: Biology Source Type: research
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women
ConclusionsAlthough women may report blunted sympathetic vasoconstriction than men when assessed separately, the similar sympathetic-mediated restriction of vasodilation suggests a similar dynamic regulation of VC between sexes. SYMP-mediated restrictions of the normal forearm vasodilation do not impair the average hyperemic response and hand re-oxygenation in both sexes. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 25, 2022 Category: Biology Source Type: research
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review
ConclusionsEach relaxin peak during the menstrual cycle can target receptors on the soft tissues supporting the TMC joint, including —critically—the main stabilizing ligament: the anterior oblique. The cyclic instability is typically asymptomatic for years after menarche, but causes cumulative chondral microtrauma. This likely causes the early-onset, high severity TMC joint OA clinically pervasive among female patients at or thopedic hand clinics. Further research is indicated to develop risk assessment strategies and potential interventional options before and after the onset of hormonal laxity-induced OA. (Source: ...
Source: Biology of Sex Differences - June 20, 2022 Category: Biology Source Type: research
Sex-specific differences in zebrafish brains
AbstractIn this systematic review, we highlight the differences between the male and female zebrafish brains to understand their differentiation and their use in studying sex-specific neurological diseases. Male and female brains display subtle differences at the cellular level which may be important in driving sex-specific signaling. Sex differences in the brain have been observed in humans as well as in non-human species. However, the molecular mechanisms of brain sex differentiation remain unclear. The classical model of brain sex differentiation suggests that the steroid hormones derived from the gonads are the primary...
Source: Biology of Sex Differences - June 17, 2022 Category: Biology Source Type: research
Sex differences in the human metabolome
ConclusionsThe recognition of sex patterns in human metabolomics has been defined in diverse biofluids. The detection of sex- and age-related differences in the metabolome of healthy individuals are helpful for translational applications from the bench to the bedside to set targeted diagnostic and prevention approaches in the context of personalized medicine.Graphical Abstract (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 15, 2022 Category: Biology Source Type: research
Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers
ConclusionsBMI is strongly associated with cumulative ACEs in women regardless the race, while waist circumference is strongly associated with ACEs in Black individuals, which combined with reduced BMI may indicate increased central adiposity in Black men. Our study suggests that sex and race influence the contribution of certain ACEs to impair metabolic health. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 15, 2022 Category: Biology Source Type: research
Nk3R blockade has sex-divergent effects on memory in mice
ConclusionThese data propose novel ideas on functional interactions between Nk3R, sex hormones, estrogen receptors, and androgen receptors in memory consolidation. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 11, 2022 Category: Biology Source Type: research
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics
AbstractSex and gender inclusion are crucial in bringing COVID-19 to an end and preventing the next pandemic. Despite this, almost all research studies on COVID-19 and clinical trials of vaccines do not include data on women. How can we combat the pandemic if half of the human population is left out of COVID-19 research? The life-long consequences of this neglect could be severe for women all over the world, particularly with the emergence of new variants that could exaggerate sex differences even further. Here I review recent studies and argue that taking a gender/sex approach to the study of this pandemic would expedite ...
Source: Biology of Sex Differences - June 8, 2022 Category: Biology Source Type: research
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis
ConclusionsThis systematic review and meta-analysis identified IMA, UA, and MDA as the most promising oxidative stress biomarkers associated with established preeclampsia. IMA as a biomarker of tissue damage exhibited the best diagnostic test accuracy. Thus, these oxidative stress biomarkers should be further explored in larger cohorts for preeclampsia diagnosis.Graphical Abstract (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 4, 2022 Category: Biology Source Type: research
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?
ConclusionsThese findings suggest sex differences in the postprandial appetite regulation that might be important for nutritional strategy to prevent and treat obesity and eating disorders. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 4, 2022 Category: Biology Source Type: research
Genetic regulation and variation of expression of miRNA and mRNA transcripts in fetal muscle tissue in the context of sex, dam and variable fetal weight
ConclusionsIntegrating information on eQTL, sex-, dam- and weight-associated differential expression and QTL for fetal weight allowed us to identify molecular pathways and shed light on the basic biological processes associated with differential muscle development in males and females, with implications for adaptive fetal programming. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 12, 2022 Category: Biology Source Type: research
