Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury
ConclusionsmiR-30a could be one of the biological factors mediating the resilience of the female preterm lung to neonatal hyperoxic lung injury. A better understanding of the effects ofmiR-30a on pulmonary angiogenesis and alveolarization may lead to novel therapeutics for treating BPD. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - August 8, 2023 Category: Biology Source Type: research
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries
ConclusionsUnder the influence of T, canaries of both sexes are able to produce generally similar vocalizations that nevertheless differ in specific ways. The development of song during ontogeny appears to be a very sophisticated process that is presumably based on genetic and endocrine mechanisms but also on specific learning processes. These data highlight the importance of detailed behavioral analyses to identify the many dimensions of a behavior that can differ between males and females. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - August 1, 2023 Category: Biology Source Type: research
Coronary artery calcification and aortic valve calcification in patients with kidney failure: a sex-disaggregated study
ConclusionsIn female KF patients inflammatory burden and oxidative stress were associated with CAC. Whereas in male KF patients oxidative stress and inflammation were associated with CAC and AVC, respectively. Our findings suggest a sex-specific biomarker signature for cardiovascular calcification that may affect the development of cardiovascular complications in males and females with KF. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 13, 2023 Category: Biology Source Type: research
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma
ConclusionsDKC1 serves as an independent female-specific predictor for survival and Sunitinib efficacy in ccRCC, which contribute to better understanding of the sex-biased ccRCC pathogenesis and improve personalized interventions of ccRCC. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 11, 2023 Category: Biology Source Type: research
Sex differences in the effects of prematurity and/or low birthweight on neurodevelopmental outcomes: systematic review and meta-analyses
ConclusionsWe found no evidence that the sexes differ in their susceptibility to the effects of severe or moderate prematurity/low birthweight on cognitive function, internalizing traits or externalizing traits. Result heterogeneity tended to be high, but this reflects that one sex is not consistently more affected than the other. Frequently stated generalizations that one sex is more susceptible to prenatal adversity should be re-evaluated. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 11, 2023 Category: Biology Source Type: research
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years
ConclusionsWe conclude that physical weakness-associated changes in muscle are sex-specific and recommend that sex differences are taken into account in research on frailty, as these differences may have a large impact on the development of (pharmaceutical) interventions against frailty.Trial registration number: The FITAAL study was registered in the Dutch Trial Register, with registration code NTR6124 on 14-11-2016 (https://trialsearch.who.int/Trial2.aspx?TrialID=NTR6124 ).Highlights• In female, but not male older adults, physical weakness was associated with a higher expression of intramuscular markers for inflammat...
Source: Biology of Sex Differences - July 10, 2023 Category: Biology Source Type: research
Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats
ConclusionsOur results suggest that there are sex-specific drinking patterns, not only in terms of total amount consumed, but specifically in terms of solution preference and access size. These findings provide a better understanding of sex and age factors involved in the development of drinking behavior, and can inform the preclinical development of models of addiction, drug development and exploration of options for new treatments. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 7, 2023 Category: Biology Source Type: research
X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events
ConclusionsXCI skewing is common in carotid plaques of females and is predictive for the occurrence of peripheral artery events within 3 years after carotid endarterectomy. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 5, 2023 Category: Biology Source Type: research
Correction: The visceral fat area to leg muscle mass ratio is significantly associated with the risk of hyperuricemia among women: a cross-sectional study
(Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 29, 2023 Category: Biology Source Type: research
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
ConclusionsOverall, these data reveal striking sex differences in cocaine-induced NAc glutamate plasticity that accompany the induction of psychomotor sensitization. This suggests that the neural adaptations that contribute to sensitization vary by sex. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 24, 2023 Category: Biology Source Type: research
Are we moving the dial? Canadian health research funding trends for women ’s health, 2S/LGBTQ + health, sex, or gender considerations
ConclusionsAlthough there was an increased number of funded grants with abstracts that mentioned sex and 2S/LGBTQ + health across time, these increases were less than 2% between 2009 and 2020. The percentage of funded grants with abstracts mentioning female-specific health or gender differences did not change significantly over time. The percentage of funding dollars allocated to grants in which the abstra cts mentioned sex or gender also did not change substantially from 2009 to 2020, with grant abstracts mentioning sex or female-specific research increasing by 1.26% and 3.47%, respectively, funding allocated to rese...
Source: Biology of Sex Differences - June 15, 2023 Category: Biology Source Type: research
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case –control study
ConclusionsThe influence of T2D-related genes, maternal T2D history, and fat distribution on T2D development was greater in males than females. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 8, 2023 Category: Biology Source Type: research
Breast cancer: the first comparative evaluation of oncobiome composition between males and females
ConclusionsBreast microbiota characterization can enhance the understanding of male breast cancer pathogenesis, being useful for detection of new prognostic biomarkers and development of innovative personalized therapies, remarking the relevant gender differences. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 5, 2023 Category: Biology Source Type: research
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
ConclusionIncreased LH and LH/FSH values in women as well as high E2 levels in men were significant predictors of better survival. Elevated LH/FSH ratio was predictive of better response to ICI in women. These results show first clinical evidence of the potential role of sex hormones as prognostic and predictive biomarker in mUC. Further prospective analyses are needed to corroborate our findings. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 5, 2023 Category: Biology Source Type: research
Integrated analysis of robust sex-biased gene signatures in human brain
AbstractBackgroundSexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the species. Accordingly, the fundamental social and cultural stratification factors for humans is sex. The sex differences are thought to emerge from a combination of genetic and environmental factors. It distinguishes individuals most prominently on the reproductive traits, but also affects many of the other related traits and manifest in different disease susceptibilities and treatment responses across sexes. Sex differences in brain have raised a lot of controversy due to...
Source: Biology of Sex Differences - May 24, 2023 Category: Biology Source Type: research
