Testosterone and depressive symptoms during the late menopause transition
ConclusionThese results suggest that, within the context of the menopause transition, times that are characterized by a higher testosterone-to-estradiol ratio may be associated with higher depressive symptoms. Perimenopausal women with a higher average ratio of testosterone relative to estradiol may also experience more sleep difficulties and vasomotor symptom bother. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - July 30, 2021 Category: Biology Source Type: research
Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammation
AbstractSexual dimorphism in the immune system is evidenced by a higher prevalence of autoimmune diseases in women and higher susceptibility to infectious diseases in men. However, the molecular basis of these sex-based differences is not fully understood. We have characterized the transcriptome profiles of peripheral blood monocytes from males and postmenopausal females with chronic low-grade inflammation. We identified 41 sexually differentially expressed genes [adjustedp value (FDR)< 0.1], including genes involved in immune cell activation (e.g.,CEACAM1,FCGR2B, andSLAMF7) and antigen presentation (e.g.,AIM2,CD1E, ...
Source: Biology of Sex Differences - July 28, 2021 Category: Biology Source Type: research
Correction to: Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique
(Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 18, 2021 Category: Biology Source Type: research
The effect of reproductive hormones on women ’s daily smoking across the menstrual cycle
ConclusionsThe present study suggests that (1) elevated progesterone levels lessen the propensity to smoke in women, (2) estrogen levels influence women ’s subjective experience of smoking, and (3) simultaneous drops or increases in these hormones are associated with increased smoking. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 10, 2021 Category: Biology Source Type: research
A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?
ConclusionsThe female gender is significantly associated with a higher prevalence of CKD among patients with urolithiasis. Therefore, women with stone disease may need close renal function monitoring during follow-up. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - June 7, 2021 Category: Biology Source Type: research
Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study
ConclusionOur study indicated a significant,non-linear, negative association between plasma selenium and first stroke in males but not in females.Trial registrationChiCTR1800017274. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 29, 2021 Category: Biology Source Type: research
A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta
ConclusionsOur results provide a comprehensive analysis of sex differences in autosomal DNAme in the term human placenta. We report a list of high-confidence autosomal sex-associated differentially methylated CpGs and identify several key features of these loci that suggest their relevance to sex differences observed in normative and complicated pregnancies. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 27, 2021 Category: Biology Source Type: research
Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique
ConclusionsPhysical activity and LV hypertrophy were accompanied by a remodelling of coronary resistance artery network geometry that was different in both sexes. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 26, 2021 Category: Biology Source Type: research
Sex differences in vancomycin-resistant enterococci bloodstream infections —a systematic review and meta-analysis
ConclusionsCurrent literature suggests sex differences with male preference (59%) in the distribution of VRE BSI cases. Further primary studies should address the question of male-specific factors favoring the enhanced frequency of VRE BSI. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 17, 2021 Category: Biology Source Type: research
Sex differences in the intestinal microbiome: interactions with risk factors for atherosclerosis and cardiovascular disease
ConclusionNovel strategies focused on resolving intestinal dysbiosis as a means to slow progression of atherosclerosis and reduce the risk of cardiovascular disease should be evaluated through a lens of sex differences. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 17, 2021 Category: Biology Source Type: research
Sex differences associated with adverse drug reactions resulting in hospital admissions
ConclusionsThere are sex-related differences in the risk of hospital admission in specific drug-ADR combinations. The most substantial differences were due to anticoagulants and diuretics. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 3, 2021 Category: Biology Source Type: research
Sex differences in soluble prorenin receptor in patients with type 2 diabetes
ConclusionsIn patients with type 2 diabetes, sPRR contributes to RAS stimulation in a sex-dependent fashion. In diabetic women, increased plasma sPRR parallels the activation of systemic RAS; while in diabetic men, decreased sPRR in urine matches intrarenal RAS stimulation. sPRR might be a potential indicator of intrarenal RAS activation and renal dysfunction in men and women with type 2 diabetes. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - May 1, 2021 Category: Biology Source Type: research
Lower variability in female students than male students at multiple timescales supports the use of sex as a biological variable in human studies
ConclusionsOur findings do not support the idea that women are more behaviorally variable than men and may support the opposite. Our findings support including sex as a biological variable and do not support variance-based arguments for the exclusion of women as research subjects. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - April 22, 2021 Category: Biology Source Type: research
Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia
ConclusionsThe rat RUPP model induced cardiac, renal and placental features reflective of preeclampsia. FKBPL was increased in the hearts of RUPP rats and cardiac spheroids treated with plasma from women with preeclampsia, perhaps reflective of restricted angiogenesis and inflammation in this disorder. Elucidation of these novel FKBPL mechanisms in cardiac health in preeclampsia could be key in preventing future CVD. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - April 20, 2021 Category: Biology Source Type: research
Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history
ConclusionsMen are at higher risk of AKI and this association is independent from existing risk factors for AKI. The association between male sex and AKI-related mortality was not independent from existing comorbidities. A better understanding of factors associated with AKI may help accurately identify high-risk patients. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - April 8, 2021 Category: Biology Source Type: research
