Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomes
ConclusionUnderstanding the biology of sex-based differences in COVID-19 severity and mortality could help inform preventative measures, treatment decisions, and development of personalized, sex-specific therapies. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 4, 2022 Category: Biology Source Type: research
Gender differences in cardiometabolic health and disease in a cross-sectional observational obesity study
ConclusionsDifferent body fat distribution patterns, particularly abdominal adiposity, adiponectin, and related biomarkers, may contribute to sex differences in cardiometabolic risk factors and to the prevalence of the MetS. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - March 4, 2022 Category: Biology Source Type: research
H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads
ConclusionsWe revealed that left/right asymmetry in H3K27ac marked chromatin activation exists in both sexes, but this discrepancy gives rise to asymmetric gonadal development only in females. Other mechanisms overriding the chromatin activation would control the symmetric development of male gonads in chicken. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - February 8, 2022 Category: Biology Source Type: research
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome
ConclusionsHFD/APOB-100 mice showed sex-specific cardiovascular responses to MetS and ET; however, left ventricular gene expressions were similar between the groups except for leptin receptor and several stress response-related genes. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 31, 2022 Category: Biology Source Type: research
Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS)
AbstractBiological processes involving environmental and genetic factors drive the interplay between age- and sex-regulating lipid profile. The relation between variations in theLPA gene with increasing the risk of coronary heart disease is dependent on population differences, sex, and age. The present study tried to do a gene candidate association analysis in people with myocardial infarction (MI) in a 22 year cohort family-based longitudinal cohort study, Tehran Cardiometabolic Genetic Study (TCGS). After adjustingp value by the FDR method, only the association of rs6415084 with the MI probability and the age-of-CHD-...
Source: Biology of Sex Differences - January 28, 2022 Category: Biology Source Type: research
Sex differences in sucrose reinforcement in Long-Evans rats
ConclusionsAcross bottle-choice, binge intake, and operant procedures, female Long-Evans rats consumed more sucrose and responded at higher rates for sucrose. Although females also responded more for water, the vigor of responding did not explain the consistent sex difference in sucrose taking and seeking. The sex difference in sucrose taking was also not explained by sweet preference, as there was no sex difference in saccharin preference. These data provide a pre-clinical model to further evaluate sex differences in addiction behaviors and manipulations designed to reduce them. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 11, 2022 Category: Biology Source Type: research
Sex and age interaction in fundamental circulatory volumetric variables at peak working capacity
ConclusionsSex and age interact on the crucial circulatory relationship between total circulating BV and peak cardiac filling, with older women necessitating more BV to fill the exercising heart than age- and physical activity-matched men. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 3, 2022 Category: Biology Source Type: research
Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen ’S chest pain rEgistry (KoROSE)
ConclusionsIn patients with chest pain undergoing invasive CAG, men had higher obstructive CAD prevalence and more high-risk angiographic findings such as LM disease or three-vessel disease. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 3, 2022 Category: Biology Source Type: research
Sex differences in the immune response to acute COVID-19 respiratory tract infection
ConclusionSex differences exist in hospitalized patients with acute COVID-19 respiratory tract infection. Exacerbated inflammatory responses were seen in male vs. female patients, even when matched for disease severity. Males appear to have a more robust innate immune response, and females mount a stronger adaptive immune response to COVID-19 respiratory tract infection. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - December 20, 2021 Category: Biology Source Type: research
Sex-related associations between body height and cognitive impairment among low-income elderly adults in rural China: a population-based cross-sectional study
ConclusionIn conclusion, shorter body height was related to cognitive impairment independently of age, educational attainment, lifestyle factors, and health-related comorbid factors among low-income elderly men in rural China. Accordingly, shorter elderly men may be targeted for effective dementia prevention in rural China. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - December 6, 2021 Category: Biology Source Type: research
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
ConclusionsThis study comprehensively compared the differences in tumor immune microenvironment between male and female LUAD patients, and identified prognosis-related genes for patients of different sexes. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - December 4, 2021 Category: Biology Source Type: research
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers
ConclusionsSex is a biological variable affecting the choice of the correct biomarker that might predict worsening of COVID-19 to severe respiratory failure. The definition of sex specific biomarkers can be useful to alert patients to be safely discharged versus those who need respiratory monitoring. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 22, 2021 Category: Biology Source Type: research
Sex and gender considerations in reporting guidelines for health research: a systematic review
ConclusionsWe assessed the integration of sex and gender in reporting guidelines based on the use of sex- and gender-related words. Our findings showed a low use and integration of sex and gender concepts and their incorrect use. Authors of reporting guidelines should reduce this gap for a better use of research knowledge.Trial registration PROSPERO no. CRD42019136491. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 20, 2021 Category: Biology Source Type: research
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
ConclusionsThese studies have identified sexually dimorphic patterns for miRNAs in maternal serum in FGR. These miRNAs may have potential as non-invasive biomarkers for FGR and associated placental dysfunction. Further studies to determine if these miRNAs have potential functional roles in the placenta may provide greater understanding of the pathogenesis of placental dysfunction and the differing susceptibility of male and female fetuses to adverse in utero conditions. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 17, 2021 Category: Biology Source Type: research
Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats
ConclusionsOur results suggest that sex differences exist in the endocannabinoid system in two CNS regions relevant to cortical spreading depression (V1M cortex) and descending modulatory networks in pain/anxiety (PAG). These basal differences in endogenous endocannabinoid mechanisms may facilitate the development of chronic pain conditions and may also underlie sex differences in response to therapeutic intervention. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 8, 2021 Category: Biology Source Type: research
