Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
ConclusionFemale mice engaged in higher volume binge drinking than their male counterparts. Although females also consumed more water than males, their higher alcohol consumption was not driven by increased total fluid intake. Further, the effects of protracted abstinence following chronic binge drinking was driven by behavioral disinhibition that was more pronounced in females. Given the reciprocal relationship between risk-taking and alcohol use in neuropsychiatric disease states, these results have implications for sex-dependent alcohol drinking patterns and their long-term negative neuropsychiatric/physiological health...
Source: Biology of Sex Differences - November 13, 2023 Category: Biology Source Type: research
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
(Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 13, 2023 Category: Biology Source Type: research
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
ConclusionsOur results indicate that hypoxia-associated pregnancy complications during late gestation can increase the risk for behavioral and physiological outcomes in offspring, such as social dysfunction, repetitive behaviors, and cognitive impairment, that are dependent on sex and age. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 11, 2023 Category: Biology Source Type: research
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
ConclusionsThese results suggest that K48-polyubiquitination differentially targets proteins in the amygdala in a sex-specific manner regardless of age. However, sexual maturity is important in the developmental regulation of K48-polyubiquitination levels in female rats. Consistent with these data, K48-polyubiquitin signaling in the amygdala is selectively required to form fear memories in female rats. Together, these data indicate that sex-differences in baseline K48-polyubiquitination within the amygdala are developmentally regulated, which could have important implications for better understanding sex-differences in mol...
Source: Biology of Sex Differences - November 10, 2023 Category: Biology Source Type: research
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
ConclusionsOur results indicate that sex differences in the gut microbiome are intestinal niche-specific and that sampling feces or the large intestine may miss significant sex effects in the small intestine. These results strongly support the need to consider both sex and reproductive status when studying the gut microbiome and while developing microbial-based therapies. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 6, 2023 Category: Biology Source Type: research
Sex matters for the enhancement of cognitive training with transcranial direct current stimulation (tDCS)
ConclusionsThis study highlights the relevance of biological sex for the effects of tDCS on cognitive training. Thus, an increased attention to biological sex is advisable in future brain stimulation research to highlight and in consequence better understand potentially underlying sex-specific mechanisms. Considering biological sex will further advance customisation and individualisation of tDCS interventions.Trial registration ClinicalTrials.gov, NCT04108663. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 2, 2023 Category: Biology Source Type: research
Increased proliferation and neuronal fate in prairie vole brain progenitor cells cultured in vitro: effects by social exposure and sexual dimorphism
ConclusionSocial interactions that promote pair bonding in voles change the properties of cells isolated from the SVZ. Thus, SE or SCM induces a bias in the differentiation potential in both sexes, while SE is sufficient to promote proliferation in SVZ-isolated cells from male brains. In females, proliferation increases when mating is performed. The next question is whether the rise in proliferation and neurogenesis of cells from the SVZ are plastic processes essential for establishing, enhancing, maintaining, or accelerating pair bond formation.HighlightsSociosexual experiences that promote pair bonding (social exposure a...
Source: Biology of Sex Differences - November 2, 2023 Category: Biology Source Type: research
Variability of temperature measurements recorded by a wearable device by biological sex
ConclusionsThese findings contradict the viewpoint that human females are too variable across menstrual cycles to include in biomedical research. Longitudinal temperature of females does not accumulate greater measurement error over time than do males and the majority of unexplained variance is within sex category, not between them. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 1, 2023 Category: Biology Source Type: research
Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys
ConclusionsThese data have important implications for the treatment of stress-related behavioral health outcomes, as they suggest that sex and social status are important factors to consider in the context of serotonergic drug efficacy. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 28, 2023 Category: Biology Source Type: research
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
ConclusionsThis study provides novel insight from lncRNA to explore the potential molecular mechanism by which DNA methylation regulates lncRNA expression to facilitate target gene transcription to reprogram sex differentiation inM.albus, which will also enrich the sex differentiation mechanism of teleosts. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 25, 2023 Category: Biology Source Type: research
Sex-specific role of galectin-3 in aortic stenosis
ConclusionsGal-3 plays a sex-differential role in the setting of AS, and it could be a new sex-specific therapeutic target controlling pathological features of AS in VICs.Graphical Abstract (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 24, 2023 Category: Biology Source Type: research
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
ConclusionsThe present results demonstrated a sex-specific role for aromatase inhibition with letrozole in the antidepressant-like response induced by ketamine in male rats. Moreover, letrozole itself presented as a potential antidepressant for females with persistent effects over time. Clearly, the production of estrogens is key in modulating, in a sex-specific manner, affective-like responses and thus deserve further studies. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 24, 2023 Category: Biology Source Type: research
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
ConclusionThere was little overlap in the IPA results for the two different DE methods. These results suggest sex differences in SON gene expression that are associated with cell signaling and ribosomal pathways. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 19, 2023 Category: Biology Source Type: research
Endothelin mediates sex-differences in acclimation to high salt diet in rats
ConclusionIn conclusion, ET receptors are crucial for mediating sex-difference in the natriuretic capacity primarily through their actions in male rats. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 10, 2023 Category: Biology Source Type: research
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
ConclusionsThe positive correlation between Adipo-IR and NAFLD was stronger in hyperlipidemic women, compared with normolipidemic or hyperlipidemic men, or normolipidemic women. The association also strengthened for women over 50 years. Treatment strategies targeting Adipo-IR to alleviate NAFLD may be of value, especially in hyperlipidemic women after menopause. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 9, 2023 Category: Biology Source Type: research
