Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies
ConclusionsOur in silico approach has highlighted sex-based differential mechanisms in typical Parkinson Disease hallmarks (inflammation, mitochondrial dysfunction, and oxidative stress). Additionally, we have identified specific genes and transcription factors for male and female Parkinson Disease patients that represent potential candidates as biomarkers to diagnosis. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 22, 2022 Category: Biology Source Type: research
Correction: Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis
(Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 10, 2022 Category: Biology Source Type: research
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance
ConclusionsOur findings suggest that RAGE-mediated adipose tissue insulin resistance is sex-specific, which is associated with different expression of genes involved in anti-oxidant and browning and insulin-induced AKT phosphorylation. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 8, 2022 Category: Biology Source Type: research
Sex differences in the medial prefrontal cortical glutamate system
ConclusionsOverall, we conclude that there are sex differences in glutamatergic transmission in the mPFC. Our data suggest that females have higher levels of glutamatergic transmission in this region. This provides evidence that the development of sex-specific pharmacotherapies for various psychiatric diseases is important to create more effective treatments. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 8, 2022 Category: Biology Source Type: research
Sex and age differences in the association of fatty liver index-defined non-alcoholic fatty liver disease with cardiometabolic risk factors: a cross-sectional study
ConclusionsMen presented a higher prevalence of NAFLD than women across all age intervals, as well as a worse cardiometabolic profile and a higher cardiovascular risk. Nevertheless, the association between FLI-defined NAFLD and diabetes or hypertension was significantly stronger in women than in men, possibly indicating that the presence of a dysmetabolic state might affect women more than men with regard to liver outcomes. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 4, 2022 Category: Biology Source Type: research
Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
ConclusionGonadal and chromosomal sex have independent effects on the hepatic transcriptome to influence different cellular pathways in a hypercholesterolemic environment. Furthermore, chromosomal sex in particular impacted the cellular response to statin treatment. An improved understanding of how gonadal and chromosomal sex influence cellular response to disease conditions and in response to drug treatment is critical to optimize disease management for all individuals. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - November 4, 2022 Category: Biology Source Type: research
Why the estrous cycle matters for neuroscience
ConclusionsWe argue that “bringing back” the estrous cycle variable to the main stage is important in order to enhance the resolution and quality of the data, to advance the health of women and other menstruators, and to make research more gender-inclusive. We strongly encourage the neuroscience community to incorporate the estrous cycle information in their study design and data analysis, whenever possible, and we debunk some myths that tend to de-emphasize the importance and discourage the inclusion of this critically important biological variable.HighlightsOvarian hormone fluctuation impacts brain physiology and is ...
Source: Biology of Sex Differences - October 28, 2022 Category: Biology Source Type: research
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise
AbstractMuscle-specific androgen receptor (AR) overexpression (HSAAR transgene) in sedentary male rats results in reduced adiposity, increased mitochondrial enzyme activity, and selective increase in Type 2b myofiber size. Here, we tested chronic endurance exercise interactions with this phenotype in both sexes. Across 9 weeks, rats ran 5×/week on motorized running wheels at increasing speeds and durations. Exercise reduced fat mass in all groups, but sex affected endurance exercise outcomes such that absolute lean mass increased only in females and total body mass decreased only in males. Expected sex difference s were...
Source: Biology of Sex Differences - October 23, 2022 Category: Biology Source Type: research
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer
ConclusionsThis study revealed that the distribution of bile acid abundances in colon cancer patients is tumor location-, age- and sex-specific, and are linked to patient prognosis. This study provides new implications for targeting bile acid metabolism, microbiome, and immune responses for colon cancer patients by taking into account primary tumor location and sex. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 23, 2022 Category: Biology Source Type: research
Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
ConclusionsConversion of progesterone to allopregnanolone correlated with smoking-related outcomes in both sex-dependent and sex-independent ways. Sex-dependent effects suggest that conversion of progesterone to allopregnanolone may contribute to greater therapeutic benefits in females but not males with TUD.Trial registration Clinicaltrials.gov registration, retrospectively registered: NCT01954966;https://clinicaltrials.gov/ct2/show/NCT01954966\ (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 23, 2022 Category: Biology Source Type: research
Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang
AbstractA wide sex disparity has been demonstrated in cancer incidence, tumor aggressiveness, prognosis, and treatment response of different types of cancer. The sex specificity of cancer appears to be a relevant issue in managing the disease, and studies investigating the role of sex and gender are becoming extremely urgent. Immunotherapy plays a le ading role in cancer treatment, offering a new perspective on advanced malignancies. Gender has not been considered in standard cancer treatment, suggesting increasing the recognition of sex differences in cancer research and clinical management. This paper provides an overv...
Source: Biology of Sex Differences - October 22, 2022 Category: Biology Source Type: research
Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland
ConclusionOur study reveals the identity and postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary. This work also highlights the importance of considering sex biases in cell-type composition when understanding sex differences in the processes regulated by the pituitary gland. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 11, 2022 Category: Biology Source Type: research
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study
ConclusionThere were more women in DLB and MCI-LB, and more men in PD-MCI and PDD. The sex distribution, demographic, and clinical characteristics differed, which strengthened the independence and heterogeneity of the four diseases, and indicated sex-sensitive strategies for management of dementia necessary. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 1, 2022 Category: Biology Source Type: research
miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice
ConclusionsWe present a novel aspect of bone –muscle crosstalk in which osteocyte-derived miR21 influences skeletal muscle size, but not strength, in female but not male mice; whereas, intracellular signaling alterations resulting from loss of miR21 seem to alter protein dynamics in a sex-dimorphic fashion. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - October 1, 2022 Category: Biology Source Type: research
Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study
ConclusionsHabitual glucosamine use to relieve osteoarthritis pain was related to lower risk of gout in females, but not in males. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - September 30, 2022 Category: Biology Source Type: research
