Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

ConclusionsConversion of progesterone to allopregnanolone correlated with smoking-related outcomes in both sex-dependent and sex-independent ways. Sex-dependent effects suggest that conversion of progesterone to allopregnanolone may contribute to greater therapeutic benefits in females but not males with TUD.Trial registration Clinicaltrials.gov registration, retrospectively registered: NCT01954966;https://clinicaltrials.gov/ct2/show/NCT01954966\

http://link.springer.com/10.1186/s13293-022-00472-w

Source: Biology of Sex Differences - October 23, 2022 Category: Biology Source Type: research