Substance P increases STAT6-mediated transcription activation of LCP2 to sustain M2 macrophage predominance in pediatric asthma
This study investigates the effect of SP on macrophage phenotype in pediatric asthma and the underpinning factors. Asthmatic children exhibited an increased level of SP, along with a higher proportion of M2 macrophages in their bronchoalveolar lavage fluid (BALF). Flow cytometry revealed that SP treatment enhanced the M2 polarization of TPA-treated THP-1 cells (macrophages) in vitro. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 21, 2023 Category: Pathology Authors: Miao Li, Xiao Zhong, Wenting Xu Tags: Regular Article Source Type: research
Correction
The authors of the article entitled, “Crosstalk between Suppression of Tumorigenicity 2 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis” (Volume 193, pages 1029–1045 of the August 2023 issue of The American Journal of Pathology; DOI: https://doi.org/10.1016/j.ajpath.2023.05.002) have alerted the edito rial office that an error was introduced to the title of the article as a result of a miscommunication with the authors during the copyediting phase of the manuscript. The original title of the manuscript used the gene symbol ST2 and the copyeditors expanded this to read “Suppression of Tu...
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Tags: Correction Source Type: research
Editorial Board
(Source: American Journal of Pathology)
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Source Type: research
Table of Contents
(Source: American Journal of Pathology)
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Source Type: research
Insight into the Role of Gut Microbiota in Duchenne Muscular Dystrophy
Dystrophin deficiency alters the sarcolemma structure, leading to muscle dystrophy, muscle disuse, and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular dystrophy have numerous transit disorders. Many studies have highlighted the strong relationship between gut microbiota and skeletal muscle. The aims of this study were: i) to characterize the gut microbiota composition over time up to 1 year in dystrophin-deficient mdx mice, and ii) to analyze the intestine structure and function and expression of genes linked to bacterial-derived metabolites in ileum, blood, and tibial anterior and soleus mus...
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Authors: Maxence Jollet, Mahendra Mariadassou, Olivier Ru é, Laurence Pessemesse, Vincent Ollendorff, Sofiane Ramdani, Barbara Vernus, Anne Bonnieu, Christelle Bertrand-Gaday, Bénédicte Goustard, Christelle Koechlin-Ramonatxo Tags: Regular article Source Type: research
Insight into the role of gut microbiota in Duchenne muscular dystrophy: an age-related study in mdx mice
Dystrophin deficiency alters the sarcolemma structure leading to muscle dystrophy, muscle disuse and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular dystrophy have many transit disorders. Many studies highlighted the strong relationship between gut microbiota and skeletal muscle. The aims of this study were i) to characterize the gut microbiota composition over time up to 1 years-old, in dystrophin-deficient mdx mice; ii) to analyse the intestine structure-function and expression of genes linked to bacterial-derived metabolites in ileum, blood, tibial anterior and soleus muscles to study inte...
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Authors: Maxence Jollet, Mahendra Mariadassou, Olivier Ru é, Laurence Pessemesse, Vincent Ollendorff, Sofiane Ramdani, Barbara Vernus, Anne Bonnieu, Christelle Bertrand-Gaday, Bénédicte Goustard, Christelle Koechlin-Ramonatxo Tags: Regular Article Source Type: research
FOXO3-activated HOTTIP Sequesters MiR-615-3p Away from COL2A1 to Mitigate Intervertebral Disc Degeneration
Knockout of FOXO3 was found to impair IVD maturation and homeostasis in postnatal mice as well as facilitating extracellular matrix (ECM) degradation. RNA sequencing can uncover disease-related gene expression and investigate disease pathophysiology. High-throughput transcriptome sequencing and experimental validations were used to identify the essential gene and mechanism involved in intervertebral disc degeneration (IDD). Nucleus pulposus (NP) tissue samples were collected from the mice with conditional knockout of FOXO3 (FOXO3 KO) for high-throughput sequencing, followed by screening of differentially expressed lncRNAs ...
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Authors: Yingjie Hao, Guangduo Zhu, Lei Yu, Zhinan Ren, Weiwei Zhou, Panke Zhang, Xu Lian Tags: Regular Article Source Type: research
Release of miR-29 target laminin C2 improves skin repair
MicroRNAs (miRs) are small non-coding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in mouse and human skin where it may regulate functions important for skin repair. Cutaneous wound healing model in miR29ab1 knockout (KO) mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis in vitro by autocrine and paracrine mechanisms. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 17, 2023 Category: Pathology Authors: Connor James Robinson, Lalitha Thiagarajan, Rebecca Maynard, Maneesha Aruketty, Jeremy Herrera, Lewis Dingle, Adam Reid, Jason Wong, Heng Cao, James Dooley, Adrian Liston, Daniela M üllhaupt, Paul Hiebert, Hayley Hiebert, Svitlana Kurinna Tags: Regular Article Source Type: research
This Month in AJP
The role of the alternative splicing factor heterogeneous nuclear ribonucleoprotein U (HNRNPU) in gastric cancer (GC) is unclear. Using molecular in vitro analysis, Dong, Wang, and Jing et al (Am J Pathol 2024, XX–XX) studied HNRNPU expression patterns to study its role in GC progression. HNRNPU expression increases significantly as gastric disease progresses, and is associated with GC development. HNRNPU promoted the proliferation, migrati on, and invasion of GC cells, while suppressing apoptosis. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 10, 2023 Category: Pathology Tags: This month in Source Type: research
Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease
Alcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacological options. The goal of the current study was to investigate the efficacy of pharmacological inhibition of soluble epoxide hydrolase (sEH, an enzyme involved in lipid metabolism) in experimental ALD and to examine the underlying mechanisms. C57BL/6J male mice underwent acute-on-chronic ethanol (EtOH) feeding with or without the sEH inhibitor, TUCB. Liver injury was assessed by multiple end-points. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Jeffrey B. Warner, Josiah E. Hardesty, Ying L. Song, Alison T. Floyd, Zhongbin Deng, Audriy Jebet, Liqing He, Xiang Zhang, Craig J. McClain, Bruce D. Hammock, Dennis R. Warner, Irina A. Kirpich Tags: Regular Article Source Type: research
Specific Polo-Like Kinase 1 Expression in Nodular Lymphocyte-Predominant Hodgkin Lymphoma Suggests an Intact Immune Surveillance Program
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare and relatively indolent B-cell lymphoma. Characteristically, the [lymphocyte-predominant (LP)] tumor cells are embedded in a microenvironment enriched in lymphocytes. More aggressive variants of mature B-cell and peripheral T-cell lymphomas exhibit nuclear expression of the polo-like kinase 1 (PLK1) protein, stabilizing c-MYC and associated with worse clinical outcomes. We demonstrate frequent expression of PLK1 in the LP cells in NLPHL cases (100%; n = 76). (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 1, 2023 Category: Pathology Authors: Jonathan Weiss, Kathryn Gibbons, Vida Ehyaee, Vanessa Perez-Silos, Alejandro Zevallos, Mark Maienschein-Cline, Eileen Brister, Maria Sverdlov, Eshana Shah, Jayalakshmi Balakrishna, Emily Symes, John K. Frederiksen, Peter H. Gann, Robert Post, Nicolas Lope Tags: Regular article Source Type: research
Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties
In this study, the expression characteristics of HNRNPU were analyzed by The Cancer Genome Atlas data, Gene Expression Omnibus data, and then further identified by real-time quantitative PCR and immunohistochemistry using tissue specimens. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 1, 2023 Category: Pathology Authors: Ying-ying Dong, Meng-ya Wang, Jing-jing Jing, Yi-jun Wu, Hao Li, Yuan Yuan, Li-ping Sun Tags: Regular article Source Type: research
Alternative Splicing Factor HNRNPU as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties
In this study, the expression characteristics of HNRNPU were analyzed by the TCGA data, GEO data, then further identified by real-time quantitative PCR and immunohistochemistry using tissue specimens. From superficial gastritis, atrophic gastritis, hyperplasia to GC, the in situ expression of HNRNPU protein gradually increased, and the AUCs for diagnosis of GC and its precancerous lesions, GC were 0.911, 0.847, respectively. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 1, 2023 Category: Pathology Authors: Ying-ying Dong, Meng-ya Wang, Jing-jing Jing, Yi-jun Wu, Hao Li, Yuan Yuan, Li-ping Sun Tags: Regular Article Source Type: research
Specific Polo-like kinase 1 (PLK1) expression in Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) suggests an intact immune surveillance program.
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare and relatively indolent B-cell lymphoma. Characteristically, the (LP-cells) tumor cells are embedded in a microenvironment enriched in lymphocytes. More aggressive variants of mature B cell and peripheral T cell lymphomas exhibit nuclear expression of the Polo-Like Kinase 1 (PLK1) protein, stabilizing c-MYC and associated with worse clinical outcomes. We demonstrate frequent expression of PLK1 in the LP-cells in NLPHL cases (100%, n = 76). (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 1, 2023 Category: Pathology Authors: Jonathan Weiss, Kathryn Gibbons, Vida Ehyaee, Vanessa Perez-Silos, Alejandro Zevallos, Mark Maienschein-Cline, Eileen Brister, Maria Sverdlov, Eshana Shah, Jayalakshmi Balakrishna, Emily Symes, John K. Frederiksen, Peter H. Gann, Robert Post, Nicolas Lope Tags: Regular Article Source Type: research
IL-6 Reduces Spheroid Sizes of Osteophytic Cells Derived from Osteoarthritis Knee Joint via Induction of Apoptosis
Osteophytes in osteoarthritis (OA) joints contribute to restriction of joint movement, joint pain, and OA progression, but little is known about osteophyte regulators. Examination of gene expression related to cartilage extracellular matrix, endochondral ossification, and growth factor signaling in articular cartilage and osteophytes obtained from OA knee joints showed that several genes such as COL1A1, VCAN, BGLAP, BMP8B, RUNX2, and SOST were overexpressed in osteophytes compared with articular cartilage. (Source: American Journal of Pathology)
Source: American Journal of Pathology - October 31, 2023 Category: Pathology Authors: Yoshifumi Negishi, Arepati Adili, Susana de Vega, Masahiro Momoeda, Haruka Kaneko, Mehmet Z. Cilek, Chiho Yoshinaga, Kazuaki Takafuji, Yuta Otsuka, Masayuki Shimoda, Takako Negishi-Koga, Muneaki Ishijima, Yasunori Okada Tags: Regular article Source Type: research
