Specific Polo-Like Kinase 1 Expression in Nodular Lymphocyte-Predominant Hodgkin Lymphoma Suggests an Intact Immune Surveillance Program

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare and relatively indolent B-cell lymphoma. Characteristically, the [lymphocyte-predominant (LP)] tumor cells are embedded in a microenvironment enriched in lymphocytes. More aggressive variants of mature B-cell and peripheral T-cell lymphomas exhibit nuclear expression of the polo-like kinase 1 (PLK1) protein, stabilizing c-MYC and associated with worse clinical outcomes. We demonstrate frequent expression of PLK1 in the LP cells in NLPHL cases (100%; n  = 76).

Source: American Journal of Pathology - November 1, 2023 Category: Pathology Authors: Jonathan Weiss, Kathryn Gibbons, Vida Ehyaee, Vanessa Perez-Silos, Alejandro Zevallos, Mark Maienschein-Cline, Eileen Brister, Maria Sverdlov, Eshana Shah, Jayalakshmi Balakrishna, Emily Symes, John K. Frederiksen, Peter H. Gann, Robert Post, Nicolas Lope Tags: Regular article Source Type: research