Insight into the Role of Gut Microbiota in Duchenne Muscular Dystrophy

Dystrophin deficiency alters the sarcolemma structure, leading to muscle dystrophy, muscle disuse, and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular dystrophy have numerous transit disorders. Many studies have highlighted the strong relationship between gut microbiota and skeletal muscle. The aims of this study were: i) to characterize the gut microbiota composition over time up to 1 year in dystrophin-deficient mdx mice, and ii) to analyze the intestine structure and function and expression of genes linked to bacterial-derived metabolites in ileum, blood, and tibial anterior and soleus muscles to study interorgan interactions.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research