Insight into the role of gut microbiota in Duchenne muscular dystrophy: an age-related study in mdx mice

Dystrophin deficiency alters the sarcolemma structure leading to muscle dystrophy, muscle disuse and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular dystrophy have many transit disorders. Many studies highlighted the strong relationship between gut microbiota and skeletal muscle. The aims of this study were i) to characterize the gut microbiota composition over time up to 1 years-old, in dystrophin-deficient mdx mice; ii) to analyse the intestine structure-function and expression of genes linked to bacterial-derived metabolites in ileum, blood, tibial anterior and soleus muscles to study inter-organ interactions.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research