IL-6 Reduces Spheroid Sizes of Osteophytic Cells Derived from Osteoarthritis Knee Joint via Induction of Apoptosis

Osteophytes in osteoarthritis (OA) joints contribute to restriction of joint movement, joint pain, and OA progression, but little is known about osteophyte regulators. Examination of gene expression related to cartilage extracellular matrix, endochondral ossification, and growth factor signaling in articular cartilage and osteophytes obtained from OA knee joints showed that several genes such as COL1A1, VCAN, BGLAP, BMP8B, RUNX2, and SOST were overexpressed in osteophytes compared with articular cartilage.

Source: American Journal of Pathology - October 31, 2023 Category: Pathology Authors: Yoshifumi Negishi, Arepati Adili, Susana de Vega, Masahiro Momoeda, Haruka Kaneko, Mehmet Z. Cilek, Chiho Yoshinaga, Kazuaki Takafuji, Yuta Otsuka, Masayuki Shimoda, Takako Negishi-Koga, Muneaki Ishijima, Yasunori Okada Tags: Regular article Source Type: research