Editorial Board
(Source: American Journal of Pathology)
Source: American Journal of Pathology - March 20, 2024 Category: Pathology Source Type: research
Table of Contents
(Source: American Journal of Pathology)
Source: American Journal of Pathology - March 20, 2024 Category: Pathology Source Type: research
Sortilin in biliary epithelial cells promotes ductular reaction and fibrosis during cholestatic injury
This study investigated the interplay between sortilin, IL-6 and LIF in cholestatic injury-induced ductular reaction, morphogenesis of new ducts and fibrosis. Cholestatic injury was induced by bile duct ligation (BDL) in WT and Sort1-/- mice, with or without augmentation of IL-6 or LIF. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 15, 2024 Category: Pathology Authors: Einav Hubel, Anat Neuman, Sigal Fishman, Ortal Schaffer, Noam Erez, Bander Abu Shrkihe, Yuval Shteingard, Tamar Gross, Oren Shibolet, Chen Varol, Isabel Zvibel Tags: Regular Article Source Type: research
Prediction of MET Overexpression in Lung Adenocarcinoma from Hematoxylin and Eosin Images
MET protein overexpression is a targetable event in non-small cell lung cancer (NSCLC) and is the subject of active drug development. Challenges in identifying patients for these therapies include lack of access to validated testing, such as standardized immunohistochemistry (IHC) assessment, and consumption of valuable tissue for a single gene/protein assay. Development of pre-screening algorithms using routinely available digitized hematoxylin and eosin (H&E)-stained slides to predict MET overexpression could promote testing for those who will benefit most. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 15, 2024 Category: Pathology Authors: Kshitij Ingale, Sun Hae Hong, Josh S.K. Bell, Abbas Rizvi, Amy Welch, Lingdao Sha, Irvin Ho, Kunal Nagpal, A ïcha Bentaieb, Rohan P. Joshi, Martin C. Stumpe Tags: Regular Article Source Type: research
Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes
In this study, human brain RNA-seq transcriptome analysis revealed a significant correlation between changes in dopaminergic signaling pathways and neural developmental signaling in ASD patients. In the zebrafish model, disrupted developmental dopaminergic signaling led to neural circuit abnormalities and behavior reminiscent of autism. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 14, 2024 Category: Pathology Authors: Xiaojuan Lu, Yixing Song, Jiaqi Wang, Yunyun Cai, Siwan Peng, Jiaqi Lin, Biqin Lai, Junjie Sun, Tianqing Liu, Gang Chen, Lingyan Xing Tags: Regular Article Source Type: research
This Month in AJP
The expression of the E3 ubiquitin ligase WSB1 is associated with hypoxia; however, its role in lung fibrosis is unclear. Using a mouse model of bleomycin (BLM)-induced lung injury and fibrosis and human embryonic lung fibroblasts, Chong and Zou et al (Am J Pathol, AJPA-D-23-00727) studied its roles. BLM injury resulted in increased WSB1 expression, which correlated with the progression of lung fibrosis. BLM-induced lung fibrosis was ameliorated by conditional deletion of Wsb1 in adult mice. Caveolin2 was identified as a downstream target of WSB1 and a functional mediator in lung injury repair and fibrosis. (Source: Americ...
Source: American Journal of Pathology - March 9, 2024 Category: Pathology Tags: This Month in AJP Source Type: research
Deletion of MyD88 in T Cells Improves Antitumor Activity in Melanoma
Cytotoxic CD8+ T cells are central to the antitumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen-presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88. However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. The authors recently reported that MyD88 limits CD4+ T-cell activation during cardiac adaptation to stress and hypothesized that a similar mechanism exists in CD8...
Source: American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Abraham L. Bayer, Darwing Padilla-Rolon, Sasha Smolgovsky, Philip Hinds, Pilar Alcaide Tags: Regular article Source Type: research
Ficolin-A/2 Aggravated Severe Lung Injury through Neutrophil Extracellular Traps Mediated by Gasdermin D –Induced Pyroptosis
This study investigated whether ficolin-A influences NET formation through pyroptosis to exacerbate lipopolysaccharide (LPS)-induced lung injury. The expression of ficolin-A/2, NETs, and pyroptosis-related molecules was investigated in animal and cell models. Knockout and knockdown (recombinant protein) methods were used to elucidate regulatory mechanisms. The Pearson correlation coefficient was used to analyze the correlation between ficolins and pyroptosis- and NET-related markers in clinical samples. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Li Huang, Xiaowu Tan, Weixia Xuan, Qing Luo, Li Xie, Yunzhu Xi, Rong Li, Li Li, Feifan Li, Meiyun Zhao, Yongliang Jiang, Xu Wu Tags: Regular article Source Type: research
Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
Neutrophil extracellular traps (NETs) and pyroptosis are critical events in lung injury. We aimed to investigate whether Ficolin-A influences NET formation through pyroptosis to exacerbate lipopolysaccharides (LPS)-induced lung injury. The expression of Ficolin-A/2, NETs, and pyroptosis-related molecules was investigated in animal and cell models. Knockout and knockdown (recombinant protein) methods were employed to elucidate regulatory mechanisms. Pearson's correlation coefficient was utilized to analyze the correlation between Ficolins and pyroptosis- and NET-related markers in clinical samples. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Li Huang, Xiaowu Tan, Weixia Xuan, Qing Luo, Li Xie, Yunzhu Xi, Rong Li, Li Li, Feifan Li, Meiyun Zhao, Yongliang Jiang, Xu Wu Tags: Regular Article Source Type: research
Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Cytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Abraham L. Bayer, Darwing Padilla-Rolon, Sasha Smolgovsky, Philip Hinds, Pilar Alcaide Tags: Regular Article Source Type: research
Tumor Necrosis Factor α–Induced Protein 8–Like Protein 1 Binds to Protein Arginine Methyltransferase 1 To Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral Squamous Cell Carcinoma
The tumor necrosis factor α–induced protein 8 (TIPE, also TNFAIP8 or OXi-α) family is a newly discovered series of proteins involved in immune regulation and tumorigenesis. TIPE1, a member of the TIPE/TNFAIP8/OXi-α family, has emerged as an anticancer-drug target, as it is promotes cancer cell apoptosis and inhibits cel l proliferation. The current study aimed to systematically reveal that TIPE1 regulates the activity of protein arginine methyltransferase (PRMT)-1 and the subsequent methylation of signal transducer and activator of transcription (STAT)-3 to suppress oral squamous cell carcinoma (OSCC) growth. (Source:...
Source: American Journal of Pathology - March 1, 2024 Category: Pathology Authors: Bing Liu, Wen Si, Bo Wei, Xuan Zhang, Peng Chen Tags: Regular article Source Type: research
Tumor necrosis factor alpha-induced protein 8-like 1 binds to protein arginine methyltransferase 1 to suppress the methylation of signal transducer and activator of transcription 3 and cell growth in oral squamous cell carcinoma
Tumor necrosis factor alpha-induced protein 8 (TIPE/TNFAIP8/OXi- α) family are a newly discovered series of proteins involved in immune regulation and tumorigenesis. TIPE1, as the member of TIPE/TNFAIP8/OXi-α family, has emerged as an anti-cancer drug target as it is promotes cancer cell apoptosis and inhibits cell proliferation. Here, the current study aimed t o systematically reveal that TIPE1 regulates the activity of protein arginine methyltransferase 1 (PRMT1) and the subsequent methylation of signal transducer and activator of transcription 3 (STAT3) to suppress oral squamous cell carcinoma (OSCC) growth. (Source: ...
Source: American Journal of Pathology - March 1, 2024 Category: Pathology Authors: Bing Liu, Wen Si, Bo Wei, Xuan Zhang, Peng Chen Tags: Regular Article Source Type: research
Decreased Proteasomal Function Exacerbates Endoplasmic Reticulum Stress-Induced Chronic Inflammation in Obese Adipose Tissue
Low-grade chronic inflammation contributes to both aging and the pathogenesis of age-related diseases. White adipose tissue (WAT) in obese individuals exhibits chronic inflammation, which is associated with obesity-related disorders. Aging exacerbates obesity-related inflammation in WAT; however, the molecular mechanisms underlying chronic inflammation and its exacerbation by aging remain unclear. Age-related decline in activity of the proteasome, a multisubunit proteolytic complex, has been implicated in age-related diseases. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 27, 2024 Category: Pathology Authors: Shimpei Nakagawa, Aya Fukui-Miyazaki, Takuma Yoshida, Yasushi Ishii, Eri Murata, Koji Taniguchi, Akihiro Ishizu, Masanori Kasahara, Utano Tomaru Tags: Regular article Source Type: research
Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion
Genetic polymorphisms that impair very low-density lipoprotein (VLDL) secretion are linked to hepatic steatosis, fibrosis, and hepatocellular cancer. Liver-specific deletion of microsomal triglyceride transfer protein (Mttp-LKO) impairs VLDL assembly, promoting hepatic steatosis and fibrosis, which are attenuated in Mttp-LKO X Fabp1 –null [Fabp1/Mttp double knockout (DKO)] mice. Here, we examine the impact of impaired VLDL secretion in Mttp-LKO mice on hepatocellular cancer incidence and progression in comparison to Fabp1/Mttp DKO mice. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 27, 2024 Category: Pathology Authors: Elizabeth P. Newberry, Elizabeth A. Molitor, Allen Liu, Kamyar Chong, Xiuli Liu, Cristina Alonso, Jose M. Mato, Nicholas O. Davidson Tags: Regular article Source Type: research
The Unrecognized Role of Ninjurin 2 in Inflammation, Metabolism, and Pyroptosis
Ninjurin family proteins are a group of double transmembrane proteins that are up-regulated in both dorsal root ganglion neurons and Schwann cells following nerve injury.1,2 The nerve injury –induced protein 1 (ninjurin 1; NINJ1) and NINJ2 are two homologous ninjurin family proteins in human beings. NINJ1 and NINJ2 are located on different chromosomes and have different expression patterns. For instance, NINJ1 is ubiquitously expressed in various epithelial tissues, whereas NINJ2 show s high expression in hematopoietic and lymphatic tissues. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 27, 2024 Category: Pathology Authors: Juan Liu, Wenwei Hu, Zhaohui Feng Tags: Commentary Source Type: research
