Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1 β, in injured corneas. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 28, 2023 Category: Pathology Authors: Zhiyi Cao, Abdulraouf Ramadan, Albert Tai, Fredrik Zetterberg, Noorjahan Panjwani Tags: Regular Article Source Type: research
Role of Hepatic Stellate and Liver Sinusoidal Endothelial Cells in a Human Primary Cell Three-Dimensional Model of Nonalcoholic Steatohepatitis (NASH)
Nonalcoholic steatohepatitis (NASH) is an inflammatory and fibrotic liver disease that has reached epidemic proportions and has no approved pharmacological therapies. Research and drug development efforts are hampered by inadequate preclinical models. This research describes a three-dimensional bioprinted liver tissue model of NASH built using primary human hepatocytes and non-parenchymal liver cells (hepatic stellate cells, liver sinusoidal endothelial cells, and Kupffer cells) from either healthy or NASH donors. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 27, 2023 Category: Pathology Authors: Philip K. Tan, Traci Ostertag, Sara B. Rosenthal, Daisy Chilin-Fuentes, Haylee Aidnik, Sara Linker, Keith Murphy, Jeffrey N. Miner, David A. Brenner Tags: Regular Article Source Type: research
Editorial Board
(Source: American Journal of Pathology)
Source: American Journal of Pathology - December 19, 2023 Category: Pathology Source Type: research
Table of Contents
(Source: American Journal of Pathology)
Source: American Journal of Pathology - December 19, 2023 Category: Pathology Source Type: research
Instructions to Authors
(Source: American Journal of Pathology)
Source: American Journal of Pathology - December 19, 2023 Category: Pathology Source Type: research
Scientific Integrity Policy
(Source: American Journal of Pathology)
Source: American Journal of Pathology - December 19, 2023 Category: Pathology Source Type: research
Androgen Receptor –Interacting Proteins in Prostate Cancer Development and Therapy Resistance
Endocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (>280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the antiandrogen enzalutamide. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 15, 2023 Category: Pathology Authors: Zoran Culig, Martin Puhr Tags: Review Source Type: research
Androgen receptor interacting proteins in prostate cancer development and therapy resistance
Endocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (> 280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the anti-androgen enzalutamide. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 15, 2023 Category: Pathology Authors: Zoran Culig, Martin Puhr Tags: Review Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Macrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1 β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bil e duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced liver injury by reducing the oxidative stress (OS)-induced inflammatory reaction in macrophages. (Source: America...
Source: American Journal of Pathology - December 15, 2023 Category: Pathology Authors: Tianfu Wen, Jing Xie, Liman Ma, Zhiqing Hao, Weiwei Zhang, Tingyao Wu, Lihua Li Tags: Regular Article Source Type: research
Clonal origin and lineage ambiguity in mixed neuroendocrine carcinoma of the uterine cervix
In this study, a panel of organoid lines from patients with SCNEC/cervix was established and focused on one line, which retained a mixed tumor phenotype, both in vitro and in vivo. Histologically, both organoids and xenograft tumors showed distinct differentiation into either SCNEC or adenocarcinoma in some regions and ambiguous differentiation in others. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 14, 2023 Category: Pathology Authors: Masamune Masuda, Keita Iida, Sadahiro Iwabuchi, Mie Tanaka, Satoshi Kubota, Hiroyuki Uematsu, Kunishige Onuma, Yoji Kukita, Kikuya Kato, Shoji Kamiura, Aya Nakajima, Roberto Coppo, Mizuki Kanda, Kiyoshi Yoshino, Yutaka Ueda, Eiichi Morii, Tadashi Kimura, Tags: Regular Article Source Type: research
IL-22 Binding Protein Controls IL-22 –Driven Bleomycin-Induced Lung Injury
The high mortality rates of acute lung injury and acute respiratory distress syndrome challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung. However, it also can exacerbate inflammation and requires tight control by the extracellular inhibitory protein known as IL-22 binding protein (IL-22BP) (Il22ra2). Here, the necessity of IL-22BP in controlling and preventing acute lung injury is shown using IL-22BP knockout mice (Il22ra2 −/−) in the bleomycin model of acute lung injury/acute respirato...
Source: American Journal of Pathology - December 13, 2023 Category: Pathology Authors: Zhe Zhang, Mazvita B. Chakawa, Joshua A. Frydman, Michaela J. Allen, Michelle Galeas Pena, MaryJane Jones, Derek Pocias Tags: Regular article Source Type: research
Suppression of Overactive Insulin-Like Growth Factor 1 Attenuates Trauma-Induced Heterotopic Ossification in Mice
In this study, using an Achilles tendon puncture-induced HO model, we revealed that overactive insulin-like growth factor 1 (IGF-1) was involved in the progression of HO in mice. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 13, 2023 Category: Pathology Authors: Dong Mao, Kai Wang, Hong Jiang, Jingyi Mi, Xiaoyun Pan, Gang Zhao, Yongjun Rui Tags: Regular article Source Type: research
IL-22 binding protein controls IL-22 driven bleomycin-induced lung injury
The high mortality rates of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung. However, it can also exacerbate inflammation and requires tight control by the extracellular inhibitory protein known as IL-22 binding protein (IL-22BP) (Il22ra2). Here we demonstrate the necessity of IL-22BP in controlling and preventing acute lung injury using IL-22BP knockout mice (Il22ra2-/-) in the bleomycin model of ALI/ARDS. (Source: A...
Source: American Journal of Pathology - December 13, 2023 Category: Pathology Authors: Zhe Zhang, Mazvita B. Chakawa, Joshua A. Frydman, Michaela J. Allen, Michelle Galeas Pena, MaryJane Jones, Derek Pociask Tags: Regular Article Source Type: research
Suppression of overactive IGF-1 attenuates trauma-induced heterotopic ossification in mice
In this study, using an Achilles tendon puncture-induced HO model, we revealed that overactive insulin-like growth factor 1 (IGF-1) was involved in the progression of HO in mice. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 13, 2023 Category: Pathology Authors: Dong Mao, Kai Wang, Hong Jiang, Jingyi Mi, Xiaoyun Pan, Gang Zhao, Yongjun Rui Tags: Regular Article Source Type: research
Vision Transformers for Breast Cancer Human Epidermal Growth Factor Receptor 2 Expression Staging without Immunohistochemical Staining
This article argues for the effectiveness of customized vision transformers in staging HER2 expression in breast cancer using only hematoxylin and eosin –stained images. This work introduces a spatial transformer network for weakly localizing critical image features before using a vision transformer-based deep learning architecture. (Source: American Journal of Pathology)
Source: American Journal of Pathology - December 12, 2023 Category: Pathology Authors: Gelan Ayana, Eonjin Lee, Se-woon Choe Tags: Regular article Source Type: research
