Role of Hepatic Stellate and Liver Sinusoidal Endothelial Cells in a Human Primary Cell Three-Dimensional Model of Nonalcoholic Steatohepatitis (NASH)

Nonalcoholic steatohepatitis (NASH) is an inflammatory and fibrotic liver disease that has reached epidemic proportions and has no approved pharmacological therapies. Research and drug development efforts are hampered by inadequate preclinical models. This research describes a three-dimensional bioprinted liver tissue model of NASH built using primary human hepatocytes and non-parenchymal liver cells (hepatic stellate cells, liver sinusoidal endothelial cells, and Kupffer cells) from either healthy or NASH donors.

https://ajp.amjpathol.org/article/S0002-9440(23)00484-4/fulltext?rss=yes

Source: American Journal of Pathology - December 27, 2023 Category: Pathology Authors: Philip K. Tan, Traci Ostertag, Sara B. Rosenthal, Daisy Chilin-Fuentes, Haylee Aidnik, Sara Linker, Keith Murphy, Jeffrey N. Miner, David A. Brenner Tags: Regular Article Source Type: research