Author Index
(Source: American Journal of Pathology)
Source: American Journal of Pathology - April 1, 2024 Category: Pathology Source Type: research
TGF- β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
Interactions between endothelial cells (ECs) and mural pericytes (PCs) are critical to maintaining the stability and function of the microvascular wall. Abnormal interactions between these two cell types are a hallmark of progressive fibrotic diseases such as systemic sclerosis (also known as scleroderma). However, the role that PCs play in signaling microvascular dysfunction remains underexplored. It is hypothesized that integrin –matrix interactions contribute to PC migration from the vascular wall and conversion into interstitial myofibroblasts. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 26, 2024 Category: Pathology Authors: Amanda S. Pellowe, Michelle J. Wu, Tae-Yun Kang, Tracy D. Chung, Adrian Ledesma-Mendoza, Erica Herzog, Andre Levchenko, Ian Odell, John Varga, Anjelica L. Gonzalez Tags: Regular article Source Type: research
Enhanced Optic Nerve Expansion and Altered Ultrastructure of Elastic Fibers Induced by Lysyl Oxidase Inhibition in a Mouse Model of Marfan Syndrome
Two major constituents of exfoliation material (XFM), fibrillin- 1 and lysyl oxidase-like 1 (encoded by FBN1 and LOXL1) are implicated in exfoliation glaucoma (XFG), yet their individual contributions to ocular phenotype are minor. To test the hypothesis that a combination of FBN1 mutation and LOXL1 deficiency exacerbates ocular phenotypes, pan-LOX inhibitor, β-aminopropionitrile (BAPN) was used to treat adult wild-type (wt) and Fbn1C1041G/+ mice for 8 weeks and their eyes were examined. Although intraocular pressure was not changed and XFM not detected in the eyes, BAPN treatment worsened optic nerve and axon expansion i...
Source: American Journal of Pathology - March 26, 2024 Category: Pathology Authors: Hang-Jing Wu, Evan Krystofiak, John Kuchtey, Rachel W. Kuchtey Tags: Regular Article Source Type: research
GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury
Acute lung injury (ALI) is a devastating clinical disease caused by different factors, with high morbidity and mortality. It has been shown that lung injury and inflammation caused by lipopolysaccharide (LPS) can be modulated by NLRP3 inflammasome activation, yet its exact function within the airway epithelium is still unknown. Meanwhile, glucose transporter protein 1 (GLUT1) has been shown to contribute to a number of inflammatory illnesses, including ALI. The present study was aimed to assess GLUT1's function in NLRP3 inflammasome activation of airway epithelium in LPS-induced acute lung injury. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 26, 2024 Category: Pathology Authors: Jiehong Li, Yijian Li, Guanjin Chen, Yan Liang, Jianpeng Xie, Shuiying Zhang, Kai Zhong, Tong Jiang, Haisu Yi, Haixiong Tang, Xin Chen Tags: Regular Article Source Type: research
Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40 –CD40L Linkage
We examined CD40 levels in HCC patient tissues and various HCC cell lines, studying their interaction with CD4+T cells. RNA sequencing analysis was performed to explore the mechanisms of CD40 induction. Poorly differentiated HCC tumour tissues exhibited high membrane-bound CD40 (mCD40) expression, in contrast to non-tumour areas. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 26, 2024 Category: Pathology Authors: Hanh Vinh Ngo, Thuy Thi Thanh Le, Hieu Ngoc Vu, Hai Hoang, Hiroko Ikenaga, Misako Sato-Matsubara, Sawako Uchida-Kobayashi, Hayato Urushima, Khanh Van Nguyen, Ha Thi Nguyen, Hiroji Shinkawa, Shoji Kubo, Naoko Ohtani, Masaru Enomoto, Akihiro Tamori, Norifum Tags: Regular Article Source Type: research
TGF β1 Drives Integrin Dependent Pericyte Migration and Microvascular Destabilization In Fibrotic Disease
Interactions between endothelial cells (EC) and mural pericytes (PC) are critical to maintaining the stability and function of the microvascular wall. Abnormal interactions between these two cell types are a hallmark of progressive fibrotic diseases, such as systemic sclerosis (SSc, scleroderma). However, the role that PCs play in signaling microvascular dysfunction remains underexplored. It is hypothesized that integrin-matrix interactions contribute to PC migration from the vascular wall and conversion into interstitial myofibroblasts. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 26, 2024 Category: Pathology Authors: Amanda S. Pellowe, Michelle J. Wu, Tae-Yun Kang, Tracy D. Chung, Adrian Ledesma-Mendoza, Erica Herzog, Andre Levchenko, Ian Odell, John Varga, Anjelica L. Gonzalez Tags: Regular Article Source Type: research
Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation
Clear-cell renal cell carcinoma (ccRCC), a tubular epithelial malignancy, secretes tumor necrosis factor (TNF), which signals ccRCC cells in an autocrine manner via two cell surface receptors, TNFR1 and TNFR2, to activate shared and distinct signaling pathways. Selective ligation of TNFR2 was shown to drive cell cycle entry of malignant cells via a signaling pathway involving epithelial tyrosine kinase, vascular endothelial cell growth factor receptor type 2, phosphatidylinositol-3-kinase, Akt, pSer727-Stat3, and mammalian target of rapamycin. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Rafia S. Al-Lamki, Aviva M. Tolkovsky, Mohammad Alawwami, WanHua Lu, Sarah F. Field, Jun Wang, Jordan S. Pober, John R. Bradley Tags: Regular article Source Type: research
A Deep Learning –Based Assessment Pipeline for Intraepithelial and Stromal Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Carcinoma
Tumor-infiltrating lymphocytes (TILs) are associated with improved survival in patients with epithelial ovarian cancer. However, the evaluation of TILs has not been applied to routine clinical practice because of reproducibility issues. We developed two convolutional neural network models to detect TILs and to determine their spatial location in whole slide images, and established a spatial assessment pipeline to objectively quantify intraepithelial and stromal TILs in patients with high-grade serous ovarian carcinoma. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Kohei Hamada, Ryusuke Murakami, Akihiko Ueda, Yoko Kashima, Chiho Miyagawa, Mana Taki, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Sachiko Minamiguchi, Noriomi Matsumura, Masaki Mandai Tags: Regular article Source Type: research
Serum fusion transcripts to assess the risk of hepatocellular carcinoma and the impact of cancer treatment through machine learning
In this study, a panel of 9 fusion transcripts in the serum samples from 136 individuals using TaqMan qRT-PCR was analyzed. Seven fusion genes were frequently detected in the serum samples of HCC patients, including MAN2A1-FER (100%), SLC45A2-AMACR (62.3%), ZMPSTE24-ZMYM4 (62.3%), PTEN-NOLC1 (57.4%), CCNH-C5orf30 (55.7%), STAMBPL1-FAS (26.2%) and PCMTD1-SNTG1 (16.4%). (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Yan-Ping Yu, Silvia Liu, David Geller, Jian-Hua Luo Tags: Regular Article Source Type: research
Different oncogenes and reproductive histories shape the progression of distinct premalignant clones in multistage mouse breast cancer models
A remote carcinogen exposure can predispose to breast cancer onset decades later, suggesting carcinogen-induced mutations generate long-lived premalignant clones. How subsequent events influence the progression of specific premalignant clones remains poorly understood. Here, we generated multistage mouse models of mammary carcinogenesis by combining chemical carcinogen exposure (using 7,12-dimethylbenzanthracene, DMBA) with transgenes that enable inducible expression of one of two clinically relevant mammary oncogenes: c-MYC (MYC) or PIK3CAH1047R (PIK). (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Maryknoll Linscott, Jerry Ruizhe Ren, Shelley Gestl, Edward J. Gunther Tags: Regular Article Source Type: research
TNF receptor-2 signals clear-cell renal carcinoma proliferation via phosphorylated-4EBP1 and mitochondrial gene translation
In this study, phosphorylated-4EBP1 serine 65 (pSer65-4EBP1) is identified as a downstream target of this TNFR2 signalling pathway. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Rafia S. Al-Lamki, Aviva M. Tolkovsky, Mohammad Alawwami, WanHua Lu, Sarah F. Field, Jun Wang, Jordan S. Pober, John R. Bradley Tags: Regular Article Source Type: research
Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion
This study aims to investigate the regulatory relationship between circadian rhythm gene cryptochrome 2 (CRY2) and ferroptosis on the migratory ability of trophoblast cells. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Faminzi Li, Liantao Guo, Mengqi Zhou, Lu Han, Shujuan Wu, Lianzhi Wu, Jing Yang Tags: Regular Article Source Type: research
A deep learning-based assessment pipeline for intraepithelial and stromal tumor-infiltrating lymphocytes in high-grade serous ovarian carcinoma
Tumor-infiltrating lymphocytes (TILs) are associated with improved survival in patients with epithelial ovarian cancer. However, the evaluation of TILs has not been applied to routine clinical practice due to reproducibility issues. We developed two convolutional neural network models to detect TILs and to determine their spatial location in whole-slide images, and established a spatial assessment pipeline to objectively quantify intraepithelial and stromal TILs in patients with high-grade serous ovarian carcinoma. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Kohei Hamada, Ryusuke Murakami, Akihiko Ueda, Yoko Kashima, Chiho Miyagawa, Mana Taki, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Sachiko Minamiguchi, Noriomi Matsumura, Masaki Mandai Tags: Regular Article Source Type: research
Advances in Understanding Cardiovascular Disease Pathogenesis through Next-Generation Technologies
In the rapidly evolving landscape of cardiovascular disease research, the integration of next-generation technologies has led to a remarkable expansion in our understanding of disease pathogenesis. This theme issue of The American Journal of Pathology on “Advances in Understanding Cardiovascular Disease Pathogenesis” includes a series of review articles that highlight this dynamic landscape. These reviews expound on the transformative impact of omics technologies to uncover novel aspects of cardiovascular disease pathogenesis and facilitate the diagnosis and treatment of cardiovascular disease. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 20, 2024 Category: Pathology Authors: Cyrine Ben Dhaou, Matthew L. Scott, A. Wayne Orr Tags: Guest editorial Source Type: research
Editorial Board
(Source: American Journal of Pathology)
Source: American Journal of Pathology - March 20, 2024 Category: Pathology Source Type: research
