IL-22 binding protein controls IL-22 driven bleomycin-induced lung injury
The high mortality rates of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung. However, it can also exacerbate inflammation and requires tight control by the extracellular inhibitory protein known as IL-22 binding protein (IL-22BP) (Il22ra2). Here we demonstrate the necessity of IL-22BP in controlling and preventing acute lung injury using IL-22BP knockout mice (Il22ra2-/-) in the bleomycin model of ALI/ARDS.
Source: American Journal of Pathology - Category: Pathology Authors: Zhe Zhang, Mazvita B. Chakawa, Joshua A. Frydman, Michaela J. Allen, Michelle Galeas Pena, MaryJane Jones, Derek Pociask Tags: Regular Article Source Type: research
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